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Protein

V-type proton ATPase subunit D

Gene

Atp6v1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-6798695 Neutrophil degranulation
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit D
Short name:
V-ATPase subunit D
Alternative name(s):
V-ATPase 28 kDa accessory protein
Vacuolar proton pump subunit D
Gene namesi
Name:Atp6v1d
Synonyms:Atp6m, Vatd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921084 Atp6v1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442321 – 247V-type proton ATPase subunit DAdd BLAST247

Proteomic databases

EPDiP57746
PaxDbiP57746
PeptideAtlasiP57746
PRIDEiP57746

PTM databases

iPTMnetiP57746
PhosphoSitePlusiP57746

Expressioni

Gene expression databases

BgeeiENSMUSG00000021114
CleanExiMM_ATP6V1D
ExpressionAtlasiP57746 baseline and differential
GenevisibleiP57746 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis (By similarity).By similarity

Protein-protein interaction databases

IntActiP57746, 5 interactors
MINTiP57746
STRINGi10090.ENSMUSP00000021536

Structurei

3D structure databases

ProteinModelPortaliP57746
SMRiP57746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase D subunit family.Curated

Phylogenomic databases

eggNOGiKOG1647 Eukaryota
COG1394 LUCA
GeneTreeiENSGT00390000010770
HOGENOMiHOG000230791
HOVERGENiHBG000483
InParanoidiP57746
KOiK02149
OMAiSKNIMGV
OrthoDBiEOG091G0A10
PhylomeDBiP57746
TreeFamiTF300160

Family and domain databases

InterProiView protein in InterPro
IPR002699 V_ATPase_D
PANTHERiPTHR11671 PTHR11671, 1 hit
PfamiView protein in Pfam
PF01813 ATP-synt_D, 1 hit
TIGRFAMsiTIGR00309 V_ATPase_subD, 1 hit

Sequencei

Sequence statusi: Complete.

P57746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK
60 70 80 90 100
IIETKMLMGE VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN
110 120 130 140 150
VAGVTLPVFE HYHEGTDSYE LTGLARGGEQ LAKLKRNYAK AVELLVELAS
160 170 180 190 200
LQTSFVTLDE AIKITNRRVN AIEHVIIPRI ERTLAYIITE LDEREREEFY
210 220 230 240
RLKKIQEKKK IIKEKFEKDL ERRRAAGEVM EPANLLAEEK DEDLLFE
Length:247
Mass (Da):28,369
Last modified:January 24, 2001 - v1
Checksum:i375C7EB2A03E8B08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298810 mRNA Translation: AAG30225.1
BC033457 mRNA Translation: AAH33457.1
CCDSiCCDS26002.1
RefSeqiNP_076210.1, NM_023721.2
UniGeneiMm.311549
Mm.491124

Genome annotation databases

EnsembliENSMUST00000021536; ENSMUSP00000021536; ENSMUSG00000021114
GeneIDi73834
KEGGimmu:73834
UCSCiuc007nzj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiVATD_MOUSE
AccessioniPrimary (citable) accession number: P57746
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: April 25, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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