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Protein

V-type proton ATPase subunit D

Gene

Atp6v1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_290403. Transferrin endocytosis and recycling.
REACT_299823. Ion channel transport.
REACT_324664. Insulin receptor recycling.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit D
Short name:
V-ATPase subunit D
Alternative name(s):
V-ATPase 28 kDa accessory protein
Vacuolar proton pump subunit D
Gene namesi
Name:Atp6v1d
Synonyms:Atp6m, Vatd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921084. Atp6v1d.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247V-type proton ATPase subunit DPRO_0000144232Add
BLAST

Proteomic databases

MaxQBiP57746.
PaxDbiP57746.
PRIDEiP57746.

PTM databases

PhosphoSiteiP57746.

Expressioni

Gene expression databases

BgeeiP57746.
CleanExiMM_ATP6V1D.
ExpressionAtlasiP57746. baseline and differential.
GenevisibleiP57746. MM.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis (By similarity).By similarity

Protein-protein interaction databases

IntActiP57746. 5 interactions.
MINTiMINT-4139796.
STRINGi10090.ENSMUSP00000021536.

Structurei

3D structure databases

ProteinModelPortaliP57746.
SMRiP57746. Positions 29-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase D subunit family.Curated

Phylogenomic databases

eggNOGiCOG1394.
HOGENOMiHOG000230791.
HOVERGENiHBG000483.
InParanoidiP57746.
KOiK02149.
OMAiQTAFMIL.
OrthoDBiEOG7QG46J.
PhylomeDBiP57746.
TreeFamiTF300160.

Family and domain databases

InterProiIPR002699. V_ATPase_D.
[Graphical view]
PANTHERiPTHR11671. PTHR11671. 1 hit.
PfamiPF01813. ATP-synt_D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00309. V_ATPase_subD. 1 hit.

Sequencei

Sequence statusi: Complete.

P57746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK
60 70 80 90 100
IIETKMLMGE VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN
110 120 130 140 150
VAGVTLPVFE HYHEGTDSYE LTGLARGGEQ LAKLKRNYAK AVELLVELAS
160 170 180 190 200
LQTSFVTLDE AIKITNRRVN AIEHVIIPRI ERTLAYIITE LDEREREEFY
210 220 230 240
RLKKIQEKKK IIKEKFEKDL ERRRAAGEVM EPANLLAEEK DEDLLFE
Length:247
Mass (Da):28,369
Last modified:January 24, 2001 - v1
Checksum:i375C7EB2A03E8B08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298810 mRNA. Translation: AAG30225.1.
BC033457 mRNA. Translation: AAH33457.1.
CCDSiCCDS26002.1.
RefSeqiNP_076210.1. NM_023721.2.
UniGeneiMm.491124.

Genome annotation databases

EnsembliENSMUST00000021536; ENSMUSP00000021536; ENSMUSG00000021114.
GeneIDi73834.
KEGGimmu:73834.
UCSCiuc007nzj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298810 mRNA. Translation: AAG30225.1.
BC033457 mRNA. Translation: AAH33457.1.
CCDSiCCDS26002.1.
RefSeqiNP_076210.1. NM_023721.2.
UniGeneiMm.491124.

3D structure databases

ProteinModelPortaliP57746.
SMRiP57746. Positions 29-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP57746. 5 interactions.
MINTiMINT-4139796.
STRINGi10090.ENSMUSP00000021536.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSiteiP57746.

Proteomic databases

MaxQBiP57746.
PaxDbiP57746.
PRIDEiP57746.

Protocols and materials databases

DNASUi73834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021536; ENSMUSP00000021536; ENSMUSG00000021114.
GeneIDi73834.
KEGGimmu:73834.
UCSCiuc007nzj.1. mouse.

Organism-specific databases

CTDi51382.
MGIiMGI:1921084. Atp6v1d.

Phylogenomic databases

eggNOGiCOG1394.
HOGENOMiHOG000230791.
HOVERGENiHBG000483.
InParanoidiP57746.
KOiK02149.
OMAiQTAFMIL.
OrthoDBiEOG7QG46J.
PhylomeDBiP57746.
TreeFamiTF300160.

Enzyme and pathway databases

ReactomeiREACT_290403. Transferrin endocytosis and recycling.
REACT_299823. Ion channel transport.
REACT_324664. Insulin receptor recycling.

Miscellaneous databases

NextBioi339163.
PROiP57746.
SOURCEiSearch...

Gene expression databases

BgeeiP57746.
CleanExiMM_ATP6V1D.
ExpressionAtlasiP57746. baseline and differential.
GenevisibleiP57746. MM.

Family and domain databases

InterProiIPR002699. V_ATPase_D.
[Graphical view]
PANTHERiPTHR11671. PTHR11671. 1 hit.
PfamiPF01813. ATP-synt_D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00309. V_ATPase_subD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, chromosomal localization and evolutionary analysis of mouse vacuolar ATPase subunit D, Atp6m."
    Kennell J.A., Richards N.W., Schaner P.E., Gumucio D.L.
    Cytogenet. Cell Genet. 92:337-341(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 7-13; 64-89 AND 183-194, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiVATD_MOUSE
AccessioniPrimary (citable) accession number: P57746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: June 24, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.