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P57746

- VATD_MOUSE

UniProt

P57746 - VATD_MOUSE

Protein

V-type proton ATPase subunit D

Gene

Atp6v1d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (24 Jan 2001)
      Previous versions | rss
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    Functioni

    Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium By similarity.By similarity

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. protein localization to cilium Source: UniProtKB
    3. proton transport Source: UniProtKB-KW

    Keywords - Biological processi

    Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit D
    Short name:
    V-ATPase subunit D
    Alternative name(s):
    V-ATPase 28 kDa accessory protein
    Vacuolar proton pump subunit D
    Gene namesi
    Name:Atp6v1d
    Synonyms:Atp6m, Vatd
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1921084. Atp6v1d.

    Subcellular locationi

    Membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated
    Note: Localizes to centrosome and the base of the cilium.By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cilium Source: Ensembl
    3. lysosomal membrane Source: Ensembl
    4. vacuolar proton-transporting V-type ATPase complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 247247V-type proton ATPase subunit DPRO_0000144232Add
    BLAST

    Proteomic databases

    MaxQBiP57746.
    PaxDbiP57746.
    PRIDEiP57746.

    PTM databases

    PhosphoSiteiP57746.

    Expressioni

    Gene expression databases

    ArrayExpressiP57746.
    BgeeiP57746.
    CleanExiMM_ATP6V1D.
    GenevestigatoriP57746.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis By similarity.By similarity

    Protein-protein interaction databases

    IntActiP57746. 5 interactions.
    MINTiMINT-4139796.
    STRINGi10090.ENSMUSP00000021536.

    Structurei

    3D structure databases

    ProteinModelPortaliP57746.
    SMRiP57746. Positions 8-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase D subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG1394.
    HOGENOMiHOG000230791.
    HOVERGENiHBG000483.
    InParanoidiP57746.
    KOiK02149.
    OMAiQTAFMIL.
    OrthoDBiEOG7QG46J.
    PhylomeDBiP57746.
    TreeFamiTF300160.

    Family and domain databases

    InterProiIPR002699. V_ATPase_D.
    [Graphical view]
    PANTHERiPTHR11671. PTHR11671. 1 hit.
    PfamiPF01813. ATP-synt_D. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00309. V_ATPase_subD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P57746-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK    50
    IIETKMLMGE VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN 100
    VAGVTLPVFE HYHEGTDSYE LTGLARGGEQ LAKLKRNYAK AVELLVELAS 150
    LQTSFVTLDE AIKITNRRVN AIEHVIIPRI ERTLAYIITE LDEREREEFY 200
    RLKKIQEKKK IIKEKFEKDL ERRRAAGEVM EPANLLAEEK DEDLLFE 247
    Length:247
    Mass (Da):28,369
    Last modified:January 24, 2001 - v1
    Checksum:i375C7EB2A03E8B08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF298810 mRNA. Translation: AAG30225.1.
    BC033457 mRNA. Translation: AAH33457.1.
    CCDSiCCDS26002.1.
    RefSeqiNP_076210.1. NM_023721.2.
    UniGeneiMm.491124.

    Genome annotation databases

    EnsembliENSMUST00000021536; ENSMUSP00000021536; ENSMUSG00000021114.
    GeneIDi73834.
    KEGGimmu:73834.
    UCSCiuc007nzj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF298810 mRNA. Translation: AAG30225.1 .
    BC033457 mRNA. Translation: AAH33457.1 .
    CCDSi CCDS26002.1.
    RefSeqi NP_076210.1. NM_023721.2.
    UniGenei Mm.491124.

    3D structure databases

    ProteinModelPortali P57746.
    SMRi P57746. Positions 8-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P57746. 5 interactions.
    MINTi MINT-4139796.
    STRINGi 10090.ENSMUSP00000021536.

    Protein family/group databases

    TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    PTM databases

    PhosphoSitei P57746.

    Proteomic databases

    MaxQBi P57746.
    PaxDbi P57746.
    PRIDEi P57746.

    Protocols and materials databases

    DNASUi 73834.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021536 ; ENSMUSP00000021536 ; ENSMUSG00000021114 .
    GeneIDi 73834.
    KEGGi mmu:73834.
    UCSCi uc007nzj.1. mouse.

    Organism-specific databases

    CTDi 51382.
    MGIi MGI:1921084. Atp6v1d.

    Phylogenomic databases

    eggNOGi COG1394.
    HOGENOMi HOG000230791.
    HOVERGENi HBG000483.
    InParanoidi P57746.
    KOi K02149.
    OMAi QTAFMIL.
    OrthoDBi EOG7QG46J.
    PhylomeDBi P57746.
    TreeFami TF300160.

    Enzyme and pathway databases

    Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Miscellaneous databases

    NextBioi 339163.
    PROi P57746.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P57746.
    Bgeei P57746.
    CleanExi MM_ATP6V1D.
    Genevestigatori P57746.

    Family and domain databases

    InterProi IPR002699. V_ATPase_D.
    [Graphical view ]
    PANTHERi PTHR11671. PTHR11671. 1 hit.
    Pfami PF01813. ATP-synt_D. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00309. V_ATPase_subD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning, chromosomal localization and evolutionary analysis of mouse vacuolar ATPase subunit D, Atp6m."
      Kennell J.A., Richards N.W., Schaner P.E., Gumucio D.L.
      Cytogenet. Cell Genet. 92:337-341(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 7-13; 64-89 AND 183-194, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiVATD_MOUSE
    AccessioniPrimary (citable) accession number: P57746
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: January 24, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3