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P57746

- VATD_MOUSE

UniProt

P57746 - VATD_MOUSE

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Protein
V-type proton ATPase subunit D
Gene
Atp6v1d, Atp6m, Vatd
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium By similarity.

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. protein localization to cilium Source: UniProtKB
  3. proton transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit D
Short name:
V-ATPase subunit D
Alternative name(s):
V-ATPase 28 kDa accessory protein
Vacuolar proton pump subunit D
Gene namesi
Name:Atp6v1d
Synonyms:Atp6m, Vatd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1921084. Atp6v1d.

Subcellular locationi

Membrane; Peripheral membrane protein; Cytoplasmic side Inferred
Note: Localizes to centrosome and the base of the cilium By similarity.

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cilium Source: Ensembl
  3. lysosomal membrane Source: Ensembl
  4. vacuolar proton-transporting V-type ATPase complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247V-type proton ATPase subunit D
PRO_0000144232Add
BLAST

Proteomic databases

MaxQBiP57746.
PaxDbiP57746.
PRIDEiP57746.

PTM databases

PhosphoSiteiP57746.

Expressioni

Gene expression databases

ArrayExpressiP57746.
BgeeiP57746.
CleanExiMM_ATP6V1D.
GenevestigatoriP57746.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis By similarity.

Protein-protein interaction databases

IntActiP57746. 5 interactions.
MINTiMINT-4139796.
STRINGi10090.ENSMUSP00000021536.

Structurei

3D structure databases

ProteinModelPortaliP57746.
SMRiP57746. Positions 8-208.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1394.
HOGENOMiHOG000230791.
HOVERGENiHBG000483.
InParanoidiP57746.
KOiK02149.
OMAiQTAFMIL.
OrthoDBiEOG7QG46J.
PhylomeDBiP57746.
TreeFamiTF300160.

Family and domain databases

InterProiIPR002699. V_ATPase_D.
[Graphical view]
PANTHERiPTHR11671. PTHR11671. 1 hit.
PfamiPF01813. ATP-synt_D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00309. V_ATPase_subD. 1 hit.

Sequencei

Sequence statusi: Complete.

P57746-1 [UniParc]FASTAAdd to Basket

« Hide

MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK    50
IIETKMLMGE VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN 100
VAGVTLPVFE HYHEGTDSYE LTGLARGGEQ LAKLKRNYAK AVELLVELAS 150
LQTSFVTLDE AIKITNRRVN AIEHVIIPRI ERTLAYIITE LDEREREEFY 200
RLKKIQEKKK IIKEKFEKDL ERRRAAGEVM EPANLLAEEK DEDLLFE 247
Length:247
Mass (Da):28,369
Last modified:January 24, 2001 - v1
Checksum:i375C7EB2A03E8B08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF298810 mRNA. Translation: AAG30225.1.
BC033457 mRNA. Translation: AAH33457.1.
CCDSiCCDS26002.1.
RefSeqiNP_076210.1. NM_023721.2.
UniGeneiMm.491124.

Genome annotation databases

EnsembliENSMUST00000021536; ENSMUSP00000021536; ENSMUSG00000021114.
GeneIDi73834.
KEGGimmu:73834.
UCSCiuc007nzj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF298810 mRNA. Translation: AAG30225.1 .
BC033457 mRNA. Translation: AAH33457.1 .
CCDSi CCDS26002.1.
RefSeqi NP_076210.1. NM_023721.2.
UniGenei Mm.491124.

3D structure databases

ProteinModelPortali P57746.
SMRi P57746. Positions 8-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P57746. 5 interactions.
MINTi MINT-4139796.
STRINGi 10090.ENSMUSP00000021536.

Protein family/group databases

TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSitei P57746.

Proteomic databases

MaxQBi P57746.
PaxDbi P57746.
PRIDEi P57746.

Protocols and materials databases

DNASUi 73834.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021536 ; ENSMUSP00000021536 ; ENSMUSG00000021114 .
GeneIDi 73834.
KEGGi mmu:73834.
UCSCi uc007nzj.1. mouse.

Organism-specific databases

CTDi 51382.
MGIi MGI:1921084. Atp6v1d.

Phylogenomic databases

eggNOGi COG1394.
HOGENOMi HOG000230791.
HOVERGENi HBG000483.
InParanoidi P57746.
KOi K02149.
OMAi QTAFMIL.
OrthoDBi EOG7QG46J.
PhylomeDBi P57746.
TreeFami TF300160.

Enzyme and pathway databases

Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Miscellaneous databases

NextBioi 339163.
PROi P57746.
SOURCEi Search...

Gene expression databases

ArrayExpressi P57746.
Bgeei P57746.
CleanExi MM_ATP6V1D.
Genevestigatori P57746.

Family and domain databases

InterProi IPR002699. V_ATPase_D.
[Graphical view ]
PANTHERi PTHR11671. PTHR11671. 1 hit.
Pfami PF01813. ATP-synt_D. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00309. V_ATPase_subD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, chromosomal localization and evolutionary analysis of mouse vacuolar ATPase subunit D, Atp6m."
    Kennell J.A., Richards N.W., Schaner P.E., Gumucio D.L.
    Cytogenet. Cell Genet. 92:337-341(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 7-13; 64-89 AND 183-194, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiVATD_MOUSE
AccessioniPrimary (citable) accession number: P57746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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