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P57746 (VATD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type proton ATPase subunit D

Short name=V-ATPase subunit D
Alternative name(s):
V-ATPase 28 kDa accessory protein
Vacuolar proton pump subunit D
Gene names
Name:Atp6v1d
Synonyms:Atp6m, Vatd
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium By similarity.

Subunit structure

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis By similarity.

Subcellular location

Membrane; Peripheral membrane protein; Cytoplasmic side Probable. Note: Localizes to centrosome and the base of the cilium By similarity.

Sequence similarities

Belongs to the V-ATPase D subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247V-type proton ATPase subunit D
PRO_0000144232

Sequences

Sequence LengthMass (Da)Tools
P57746 [UniParc].

Last modified January 24, 2001. Version 1.
Checksum: 375C7EB2A03E8B08

FASTA24728,369
        10         20         30         40         50         60 
MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK IIETKMLMGE 

        70         80         90        100        110        120 
VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN VAGVTLPVFE HYHEGTDSYE 

       130        140        150        160        170        180 
LTGLARGGEQ LAKLKRNYAK AVELLVELAS LQTSFVTLDE AIKITNRRVN AIEHVIIPRI 

       190        200        210        220        230        240 
ERTLAYIITE LDEREREEFY RLKKIQEKKK IIKEKFEKDL ERRRAAGEVM EPANLLAEEK 


DEDLLFE 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning, chromosomal localization and evolutionary analysis of mouse vacuolar ATPase subunit D, Atp6m."
Kennell J.A., Richards N.W., Schaner P.E., Gumucio D.L.
Cytogenet. Cell Genet. 92:337-341(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
[3]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 7-13; 64-89 AND 183-194, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[4]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF298810 mRNA. Translation: AAG30225.1.
BC033457 mRNA. Translation: AAH33457.1.
RefSeqNP_076210.1. NM_023721.2.
UniGeneMm.491124.

3D structure databases

ProteinModelPortalP57746.
SMRP57746. Positions 8-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP57746. 5 interactions.
MINTMINT-4139796.
STRING10090.ENSMUSP00000021536.

Protein family/group databases

TCDB3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSiteP57746.

Proteomic databases

PaxDbP57746.
PRIDEP57746.

Protocols and materials databases

DNASU73834.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021536; ENSMUSP00000021536; ENSMUSG00000021114.
GeneID73834.
KEGGmmu:73834.
UCSCuc007nzj.1. mouse.

Organism-specific databases

CTD51382.
MGIMGI:1921084. Atp6v1d.

Phylogenomic databases

eggNOGCOG1394.
HOGENOMHOG000230791.
HOVERGENHBG000483.
InParanoidP57746.
KOK02149.
OMAQSKNIMG.
OrthoDBEOG7QG46J.
PhylomeDBP57746.
TreeFamTF300160.

Gene expression databases

ArrayExpressP57746.
BgeeP57746.
CleanExMM_ATP6V1D.
GenevestigatorP57746.

Family and domain databases

InterProIPR002699. V_ATPase_D.
[Graphical view]
PANTHERPTHR11671. PTHR11671. 1 hit.
PfamPF01813. ATP-synt_D. 1 hit.
[Graphical view]
TIGRFAMsTIGR00309. V_ATPase_subD. 1 hit.
ProtoNetSearch...

Other

NextBio339163.
PROP57746.
SOURCESearch...

Entry information

Entry nameVATD_MOUSE
AccessionPrimary (citable) accession number: P57746
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot