P57746 (VATD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type proton ATPase subunit D
Short name=V-ATPase subunit D

Alternative name(s):
V-ATPase 28 kDa accessory protein
Vacuolar proton pump subunit D

Gene names

Name:	Atp6v1d
Synonyms:	Atp6m, Vatd

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system By similarity.
Subunit structure	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Sequence similarities	Belongs to the V-ATPase D subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	proton transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	vacuolar proton-transporting V-type ATPase complex Inferred from electronic annotation. Source: Compara
Molecular_function	ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	V-type proton ATPase subunit D		PRO_0000144232

Sequences

	Sequence		Length	Mass (Da)
	P57746 [UniParc]. Last modified January 24, 2001. Version 1. Checksum: 375C7EB2A03E8B08	FASTA	247	28,369
	10 20 30 40 50 60 MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK IIETKMLMGE 70 80 90 100 110 120 VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN VAGVTLPVFE HYHEGTDSYE 130 140 150 160 170 180 LTGLARGGEQ LAKLKRNYAK AVELLVELAS LQTSFVTLDE AIKITNRRVN AIEHVIIPRI 190 200 210 220 230 240 ERTLAYIITE LDEREREEFY RLKKIQEKKK IIKEKFEKDL ERRRAAGEVM EPANLLAEEK DEDLLFE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning, chromosomal localization and evolutionary analysis of mouse vacuolar ATPase subunit D, Atp6m." Kennell J.A., Richards N.W., Schaner P.E., Gumucio D.L. Cytogenet. Cell Genet. 92:337-341(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary gland.
[3]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 7-13; 64-89 AND 183-194, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF298810 mRNA. Translation: AAG30225.1. BC033457 mRNA. Translation: AAH33457.1.
IPI	IPI00118787.
RefSeq	NP_076210.1. NM_023721.2.
UniGene	Mm.311549.
3D structure databases
ProteinModelPortal	P57746.
SMR	P57746. Positions 11-208.
ModBase	Search...
Protein-protein interaction databases
IntAct	P57746. 2 interactions.
STRING	10090.ENSMUSP00000021536.
PTM databases
PhosphoSite	P57746.
Proteomic databases
PaxDb	P57746.
PRIDE	P57746.
Protocols and materials databases
DNASU	73834.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000021536; ENSMUSP00000021536; ENSMUSG00000021114.
GeneID	73834.
KEGG	mmu:73834.
Organism-specific databases
CTD	51382.
MGI	MGI:1921084. Atp6v1d.
Phylogenomic databases
eggNOG	COG1394.
HOGENOM	HOG000230791.
HOVERGEN	HBG000483.
InParanoid	P57746.
KO	K02149.
OMA	FPTRMTL.
OrthoDB	EOG41NTMW.
Gene expression databases
ArrayExpress	P57746.
Bgee	P57746.
CleanEx	MM_ATP6V1D.
Genevestigator	P57746.
GermOnline	ENSMUSG00000021114. Mus musculus.
Family and domain databases
InterPro	IPR002699. V_ATPase_D. [Graphical view]
PANTHER	PTHR11671. PTHR11671. 1 hit.
Pfam	PF01813. ATP-synt_D. 1 hit. [Graphical view]
TIGRFAMs	TIGR00309. V_ATPase_subD. 1 hit.
ProtoNet	Search...
Other
NextBio	339163.
SOURCE	Search...

Entry information

Entry name

VATD_MOUSE

Accession

Primary (citable) accession number: P57746

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	January 24, 2001
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program