Reviewed, UniProtKB/Swiss-Prot P57738 (TCTA_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell leukemia translocation-altered gene protein
Alternative name(s):
    T-cell leukemia translocation-associated gene protein

Gene names

Name:

TCTA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Ubiquitous. Highest level of expression in kidney. Ref.1
Involvement in disease	A chromosomal aberration involving TCTA is associated with T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(1;3)(p34;p21).
Sequence similarities	Belongs to the TCTA family.

Ontologies

Keywords
Coding sequence diversity	Chromosomal rearrangement
Disease	Proto-oncogene
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	T-cell leukemia translocation-altered gene protein		PRO_0000072470
Experimental info
	Sequence conflict	103	1	E → D in CAG33692. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P57738-1 [UniParc]. Last modified January 11, 2001. Version 1. Checksum: 62FA7ECC2241D85E	FASTA	103	11,341
	10 20 30 40 50 60 MAESWSGQAL QALPATVLGA LGSEFLREWE AQDMRVTLFK LLLLWLVLSL LGIQLAWGFY 70 80 90 100 GNTVTGLYHR PGLGGQNGST PDGSTHFPSW EMAANEPLKT HRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation." Aplan P.D., Johnson B.E., Russell E., Chervinsky D.S., Kirsch I.R. Cancer Res. 55:1917-1921(1995) [PubMed: 7728759] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	L41143 mRNA. Translation: AAA97514.1. AK311839 mRNA. Translation: BAG34781.1. CR457411 mRNA. Translation: CAG33692.1. BC005157 mRNA. Translation: AAH05157.2.
IPI	IPI00027997.
PIR	I52722.
RefSeq	NP_071503.1.
UniGene	Hs.517962
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000145022. Homo sapiens. [Contig view]
GeneID	6988.
KEGG	hsa:6988.
Organism-specific databases
GeneCards	GC03P049424.
H-InvDB	HIX0003301.
HGNC	HGNC:11692. TCTA.
HPA	HPA007342.
MIM	600690. gene.
PharmGKB	PA36412.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P57738.
HOVERGEN	P57738.
OMA	P57738. FYGSTVT.
Gene expression databases
Bgee	P57738.
CleanEx	HS_TCTA.
GermOnline	ENSG00000145022. Homo sapiens.
Family and domain databases
InterPro	IPR016560. T-cell_leukemia_transloc-assoc. [Graphical view]
PIRSF	PIRSF009935. TCTA. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	27305.
SOURCE	Search...

Entry information

Entry name

TCTA_HUMAN

Accession

Primary (citable) accession number: P57738
Secondary accession number(s): B2R4I4, Q6I9U4, Q9BSB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	January 11, 2001
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)