Reviewed,
UniProtKB/Swiss-Prot P57738 (TCTA_HUMAN)
Last modified
June 16, 2009.
Version 52.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: T-cell leukemia translocation-altered gene protein Alternative name(s): T-cell leukemia translocation-associated gene protein | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 103 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Tissue specificity | Ubiquitous. Highest level of expression in kidney. Ref.1 |
| Involvement in disease | A chromosomal aberration involving TCTA is associated with T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(1;3)(p34;p21). |
| Sequence similarities | Belongs to the TCTA family. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Chromosomal rearrangement |
| Disease | Proto-oncogene |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation." Aplan P.D., Johnson B.E., Russell E., Chervinsky D.S., Kirsch I.R. Cancer Res. 55:1917-1921(1995) [PubMed: 7728759] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION, TISSUE SPECIFICITY. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle. |
Cross-references
Sequence databases | |
|---|---|
| L41143 mRNA. Translation: AAA97514.1. AK311839 mRNA. Translation: BAG34781.1. CR457411 mRNA. Translation: CAG33692.1. BC005157 mRNA. Translation: AAH05157.2. | |
| IPI | IPI00027997. |
| PIR | I52722. |
| RefSeq | NP_071503.1. |
| UniGene | Hs.517962 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000145022. Homo sapiens. [Contig view] |
| GeneID | 6988. |
| KEGG | hsa:6988. |
Organism-specific databases | |
| GeneCards | GC03P049424. |
| H-InvDB | HIX0003301. |
| HGNC | HGNC:11692. TCTA. |
| HPA | HPA007342. |
| MIM | 600690. gene. |
| PharmGKB | PA36412. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P57738. |
| HOVERGEN | P57738. |
| OMA | P57738. FYGSTVT. |
Gene expression databases | |
| Bgee | P57738. |
| CleanEx | HS_TCTA. |
| GermOnline | ENSG00000145022. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016560. T-cell_leukemia_transloc-assoc. [Graphical view] |
| PIRSF | PIRSF009935. TCTA. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 27305. |
| SOURCE | Search... |
Entry information
| Entry name | TCTA_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P57738 Secondary accession number(s): B2R4I4, Q6I9U4, Q9BSB0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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