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Protein

T-cell leukemia translocation-altered gene protein

Gene

TCTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be required for cellular fusion during osteoclastogenesis.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia translocation-altered gene protein
Alternative name(s):
T-cell leukemia translocation-associated gene protein
Gene namesi
Name:TCTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11692. TCTA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 87ExtracellularSequence analysis
Transmembranei9 – 2618HelicalSequence analysisAdd
BLAST
Topological domaini27 – 4014CytoplasmicSequence analysisAdd
BLAST
Transmembranei41 – 6121HelicalSequence analysisAdd
BLAST
Topological domaini62 – 10342ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TCTA is associated with T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(1;3)(p34;p21).

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA36412.

Polymorphism and mutation databases

BioMutaiTCTA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 103102T-cell leukemia translocation-altered gene proteinPRO_0000072470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

MaxQBiP57738.
PaxDbiP57738.
PeptideAtlasiP57738.
TopDownProteomicsiP57738.

PTM databases

PhosphoSiteiP57738.

Expressioni

Tissue specificityi

Ubiquitous. Highest level of expression in kidney. Present in monocytes, osteoclasts, macrophages, synoviocytes and synovial lining cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000145022.
CleanExiHS_TCTA.
GenevisibleiP57738. HS.

Organism-specific databases

HPAiHPA007342.

Interactioni

Protein-protein interaction databases

BioGridi112848. 2 interactions.
IntActiP57738. 2 interactions.
MINTiMINT-1198300.
STRINGi9606.ENSP00000273590.

Structurei

3D structure databases

ProteinModelPortaliP57738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCTA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3NY. Eukaryota.
ENOG41127ZJ. LUCA.
GeneTreeiENSGT00390000004490.
HOGENOMiHOG000154534.
HOVERGENiHBG017901.
InParanoidiP57738.
OMAiAWGFYGS.
OrthoDBiEOG091G0X5J.
PhylomeDBiP57738.
TreeFamiTF330748.

Family and domain databases

InterProiIPR016560. TCTA.
[Graphical view]
PfamiPF15128. T_cell_tran_alt. 1 hit.
[Graphical view]
PIRSFiPIRSF009935. TCTA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESWSGQAL QALPATVLGA LGSEFLREWE AQDMRVTLFK LLLLWLVLSL
60 70 80 90 100
LGIQLAWGFY GNTVTGLYHR PGLGGQNGST PDGSTHFPSW EMAANEPLKT

HRE
Length:103
Mass (Da):11,341
Last modified:January 11, 2001 - v1
Checksum:i62FA7ECC2241D85E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031E → D in CAG33692 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41143 mRNA. Translation: AAA97514.1.
AK311839 mRNA. Translation: BAG34781.1.
CR457411 mRNA. Translation: CAG33692.1.
AC104452 Genomic DNA. No translation available.
BC005157 mRNA. Translation: AAH05157.2.
CCDSiCCDS2796.1.
PIRiI52722.
RefSeqiNP_071503.1. NM_022171.2.
UniGeneiHs.517962.

Genome annotation databases

EnsembliENST00000273590; ENSP00000273590; ENSG00000145022.
GeneIDi6988.
KEGGihsa:6988.
UCSCiuc003cwv.5. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41143 mRNA. Translation: AAA97514.1.
AK311839 mRNA. Translation: BAG34781.1.
CR457411 mRNA. Translation: CAG33692.1.
AC104452 Genomic DNA. No translation available.
BC005157 mRNA. Translation: AAH05157.2.
CCDSiCCDS2796.1.
PIRiI52722.
RefSeqiNP_071503.1. NM_022171.2.
UniGeneiHs.517962.

3D structure databases

ProteinModelPortaliP57738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112848. 2 interactions.
IntActiP57738. 2 interactions.
MINTiMINT-1198300.
STRINGi9606.ENSP00000273590.

PTM databases

PhosphoSiteiP57738.

Polymorphism and mutation databases

BioMutaiTCTA.

Proteomic databases

MaxQBiP57738.
PaxDbiP57738.
PeptideAtlasiP57738.
TopDownProteomicsiP57738.

Protocols and materials databases

DNASUi6988.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273590; ENSP00000273590; ENSG00000145022.
GeneIDi6988.
KEGGihsa:6988.
UCSCiuc003cwv.5. human.

Organism-specific databases

CTDi6988.
GeneCardsiTCTA.
HGNCiHGNC:11692. TCTA.
HPAiHPA007342.
MIMi600690. gene.
neXtProtiNX_P57738.
PharmGKBiPA36412.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3NY. Eukaryota.
ENOG41127ZJ. LUCA.
GeneTreeiENSGT00390000004490.
HOGENOMiHOG000154534.
HOVERGENiHBG017901.
InParanoidiP57738.
OMAiAWGFYGS.
OrthoDBiEOG091G0X5J.
PhylomeDBiP57738.
TreeFamiTF330748.

Miscellaneous databases

ChiTaRSiTCTA. human.
GenomeRNAii6988.
PROiP57738.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145022.
CleanExiHS_TCTA.
GenevisibleiP57738. HS.

Family and domain databases

InterProiIPR016560. TCTA.
[Graphical view]
PfamiPF15128. T_cell_tran_alt. 1 hit.
[Graphical view]
PIRSFiPIRSF009935. TCTA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTCTA_HUMAN
AccessioniPrimary (citable) accession number: P57738
Secondary accession number(s): B2R4I4, Q6I9U4, Q9BSB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.