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Protein

Coronin-7

Gene

CORO7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.2 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

  • actin filament polymerization Source: UniProtKB
  • Golgi to endosome transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

SignaLinkiP57737.

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-7
Short name:
Crn7
Alternative name(s):
70 kDa WD repeat tumor rejection antigen homolog
Gene namesi
Name:CORO7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26161. CORO7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB-SubCell
  • cytosol Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi472 – 4721K → R: Impaired ability to regulate the anterograde Golgi to endosome transport. 1 Publication
Mutagenesisi680 – 6801K → R: Does not affect ability to regulate the anterograde Golgi to endosome transport. 1 Publication

Organism-specific databases

PharmGKBiPA134910806.

Polymorphism and mutation databases

BioMutaiCORO7.
DMDMi259016200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 925925Coronin-7PRO_0000050934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei462 – 4621PhosphoserineBy similarity
Modified residuei465 – 4651PhosphoserineBy similarity
Cross-linki472 – 472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki680 – 680Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei915 – 9151PhosphoserineBy similarity

Post-translational modificationi

The membrane-associated form is phosphorylated on tyrosine residues.By similarity
Ubiquitinated via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: 'Lys-33'-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP57737.
MaxQBiP57737.
PaxDbiP57737.
PRIDEiP57737.

PTM databases

iPTMnetiP57737.
PhosphoSiteiP57737.

Expressioni

Tissue specificityi

Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.1 Publication

Gene expression databases

BgeeiP57737.
CleanExiHS_CORO7.
ExpressionAtlasiP57737. baseline and differential.
GenevisibleiP57737. HS.

Organism-specific databases

HPAiHPA041657.
HPA053586.

Interactioni

Subunit structurei

Interacts with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not AP1-positive endosomal membranes. Interacts (when ubiquitinated at Lys-472) with EPS15.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Tob1Q614713EBI-6916167,EBI-8527498From a different organism.

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122728. 28 interactions.
IntActiP57737. 13 interactions.
STRINGi9606.ENSP00000460885.

Structurei

3D structure databases

ProteinModelPortaliP57737.
SMRiP57737. Positions 7-385, 444-867.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati75 – 11541WD 1Add
BLAST
Repeati124 – 16340WD 2Add
BLAST
Repeati166 – 20540WD 3Add
BLAST
Repeati209 – 25345WD 4Add
BLAST
Repeati542 – 58241WD 5Add
BLAST
Repeati592 – 63241WD 6Add
BLAST
Repeati635 – 67440WD 7Add
BLAST
Repeati728 – 76841WD 8Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1445. Eukaryota.
KOG3442. Eukaryota.
ENOG410XPE7. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000006535.
HOVERGENiHBG051080.
InParanoidiP57737.
KOiK18619.
OMAiKIAIFEL.
OrthoDBiEOG76X5ZX.
PhylomeDBiP57737.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015505. Coronin.
IPR015048. DUF1899.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PfamiPF08953. DUF1899. 2 hits.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01166. DUF1899. 2 hits.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P57737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRFRVSKFR HTEARPPRRE SWISDIRAGT APSCRNHIKS SCSLIAFNSD
60 70 80 90 100
RPGVLGIVPL QGQGEDKRRV AHLGCHSDLV TDLDFSPFDD FLLATGSADR
110 120 130 140 150
TVKLWRLPGP GQALPSAPGV VLGPEDLPVE VLQFHPTSDG ILVSAAGTTV
160 170 180 190 200
KVWDAAKQQP LTELAAHGDL VQSAVWSRDG ALVGTACKDK QLRIFDPRTK
210 220 230 240 250
PRASQSTQAH ENSRDSRLAW MGTWEHLVST GFNQMREREV KLWDTRFFSS
260 270 280 290 300
ALASLTLDTS LGCLVPLLDP DSGLLVLAGK GERQLYCYEV VPQQPALSPV
310 320 330 340 350
TQCVLESVLR GAALVPRQAL AVMSCEVLRV LQLSDTAIVP IGYHVPRKAV
360 370 380 390 400
EFHEDLFPDT AGCVPATDPH SWWAGDNQQV QKVSLNPACR PHPSFTSCLV
410 420 430 440 450
PPAEPLPDTA QPAVMETPVG DADASEGFSS PPSSLTSPST PSSLGPSLSS
460 470 480 490 500
TSGIGTSPSL RSLQSLLGPS SKFRHAQGTV LHRDSHITNL KGLNLTTPGE
510 520 530 540 550
SDGFCANKLR VAVPLLSSGG QVAVLELRKP GRLPDTALPT LQNGAAVTDL
560 570 580 590 600
AWDPFDPHRL AVAGEDARIR LWRVPAEGLE EVLTTPETVL TGHTEKICSL
610 620 630 640 650
RFHPLAANVL ASSSYDLTVR IWDLQAGADR LKLQGHQDQI FSLAWSPDGQ
660 670 680 690 700
QLATVCKDGR VRVYRPRSGP EPLQEGPGPK GGRGARIVWV CDGRCLLVSG
710 720 730 740 750
FDSQSERQLL LYEAEALAGG PLAVLGLDVA PSTLLPSYDP DTGLVLLTGK
760 770 780 790 800
GDTRVFLYEL LPESPFFLEC NSFTSPDPHK GLVLLPKTEC DVREVELMRC
810 820 830 840 850
LRLRQSSLEP VAFRLPRVRK EFFQDDVFPD TAVIWEPVLS AEAWLQGANG
860 870 880 890 900
QPWLLSLQPP DMSPVSQAPR EAPARRAPSS AQYLEEKSDQ QKKEELLNAM
910 920
VAKLGNREDP LPQDSFEGVD EDEWD
Length:925
Mass (Da):100,605
Last modified:September 22, 2009 - v2
Checksum:iFC8680F8CCB409C0
GO
Isoform 2 (identifier: P57737-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-162: Missing.

Note: No experimental confirmation available.
Show »
Length:840
Mass (Da):91,655
Checksum:i0C11C60E67B6724C
GO
Isoform 3 (identifier: P57737-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     925-925: D → AKYLAQIIVM...DREKGQMPHT

Note: No experimental confirmation available.Curated
Show »
Length:1,048
Mass (Da):114,166
Checksum:iD5E7A7A7418F3DDC
GO
Isoform 4 (identifier: P57737-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-95: Missing.

Note: No experimental confirmation available.
Show »
Length:907
Mass (Da):98,579
Checksum:i7C3C5C07E5FA2C8C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti324 – 3241S → G in BAB15211 (PubMed:14702039).Curated
Sequence conflicti371 – 3711S → G in BAB15211 (PubMed:14702039).Curated
Sequence conflicti848 – 8481A → T in BAB15211 (PubMed:14702039).Curated
Isoform 3 (identifier: P57737-3)
Sequence conflicti1037 – 10371Q → K in BC032732 (PubMed:15616553).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741A → V.
Corresponds to variant rs17137007 [ dbSNP | Ensembl ].
VAR_057585
Natural varianti193 – 1931R → Q.1 Publication
Corresponds to variant rs3747579 [ dbSNP | Ensembl ].
VAR_057586
Natural varianti257 – 2571L → S.
Corresponds to variant rs35357594 [ dbSNP | Ensembl ].
VAR_057587
Natural varianti403 – 4031A → T.
Corresponds to variant rs9928967 [ dbSNP | Ensembl ].
VAR_057588

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei78 – 16285Missing in isoform 2. 1 PublicationVSP_038152Add
BLAST
Alternative sequencei78 – 9518Missing in isoform 4. 1 PublicationVSP_046752Add
BLAST
Alternative sequencei925 – 9251D → AKYLAQIIVMGVQVVGRAFA RALRQEFAASRAAADARGRA GHRSAAASNLSGLSLQEAQQ ILNVSKLSPEEVQKNYEHLF KVNDKSVGGSFYLQSKVVRA KERLDEELKIQAQEDREKGQ MPHT in isoform 3. 1 PublicationVSP_046022

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025674 mRNA. Translation: BAB15211.1.
AK294045 mRNA. Translation: BAG57397.1.
AK296807 mRNA. Translation: BAG59380.1.
AC012676 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85307.1.
BC032732 mRNA. No translation available.
BC117289 mRNA. Translation: AAI17290.1.
BC117291 mRNA. Translation: AAI17292.1.
CCDSiCCDS10513.1. [P57737-1]
CCDS55982.1. [P57737-2]
CCDS58417.1. [P57737-4]
RefSeqiNP_001188401.1. NM_001201472.1. [P57737-4]
NP_001188402.1. NM_001201473.1. [P57737-2]
NP_078811.3. NM_024535.4. [P57737-1]
UniGeneiHs.437957.
Hs.739021.

Genome annotation databases

EnsembliENST00000251166; ENSP00000251166; ENSG00000262246. [P57737-1]
ENST00000537233; ENSP00000440460; ENSG00000262246. [P57737-4]
ENST00000574025; ENSP00000461702; ENSG00000262246. [P57737-2]
ENST00000614702; ENSP00000482646; ENSG00000282725. [P57737-1]
ENST00000617235; ENSP00000483187; ENSG00000282725. [P57737-4]
ENST00000631534; ENSP00000488867; ENSG00000282725. [P57737-2]
GeneIDi79585.
KEGGihsa:79585.
UCSCiuc002cwh.5. human. [P57737-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025674 mRNA. Translation: BAB15211.1.
AK294045 mRNA. Translation: BAG57397.1.
AK296807 mRNA. Translation: BAG59380.1.
AC012676 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85307.1.
BC032732 mRNA. No translation available.
BC117289 mRNA. Translation: AAI17290.1.
BC117291 mRNA. Translation: AAI17292.1.
CCDSiCCDS10513.1. [P57737-1]
CCDS55982.1. [P57737-2]
CCDS58417.1. [P57737-4]
RefSeqiNP_001188401.1. NM_001201472.1. [P57737-4]
NP_001188402.1. NM_001201473.1. [P57737-2]
NP_078811.3. NM_024535.4. [P57737-1]
UniGeneiHs.437957.
Hs.739021.

3D structure databases

ProteinModelPortaliP57737.
SMRiP57737. Positions 7-385, 444-867.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122728. 28 interactions.
IntActiP57737. 13 interactions.
STRINGi9606.ENSP00000460885.

PTM databases

iPTMnetiP57737.
PhosphoSiteiP57737.

Polymorphism and mutation databases

BioMutaiCORO7.
DMDMi259016200.

Proteomic databases

EPDiP57737.
MaxQBiP57737.
PaxDbiP57737.
PRIDEiP57737.

Protocols and materials databases

DNASUi79585.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251166; ENSP00000251166; ENSG00000262246. [P57737-1]
ENST00000537233; ENSP00000440460; ENSG00000262246. [P57737-4]
ENST00000574025; ENSP00000461702; ENSG00000262246. [P57737-2]
ENST00000614702; ENSP00000482646; ENSG00000282725. [P57737-1]
ENST00000617235; ENSP00000483187; ENSG00000282725. [P57737-4]
ENST00000631534; ENSP00000488867; ENSG00000282725. [P57737-2]
GeneIDi79585.
KEGGihsa:79585.
UCSCiuc002cwh.5. human. [P57737-1]

Organism-specific databases

CTDi79585.
GeneCardsiCORO7.
H-InvDBHIX0012777.
HGNCiHGNC:26161. CORO7.
HPAiHPA041657.
HPA053586.
MIMi611668. gene.
neXtProtiNX_P57737.
PharmGKBiPA134910806.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1445. Eukaryota.
KOG3442. Eukaryota.
ENOG410XPE7. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000006535.
HOVERGENiHBG051080.
InParanoidiP57737.
KOiK18619.
OMAiKIAIFEL.
OrthoDBiEOG76X5ZX.
PhylomeDBiP57737.
TreeFamiTF314280.

Enzyme and pathway databases

SignaLinkiP57737.

Miscellaneous databases

GenomeRNAii79585.
PROiP57737.
SOURCEiSearch...

Gene expression databases

BgeeiP57737.
CleanExiHS_CORO7.
ExpressionAtlasiP57737. baseline and differential.
GenevisibleiP57737. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015505. Coronin.
IPR015048. DUF1899.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PfamiPF08953. DUF1899. 2 hits.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01166. DUF1899. 2 hits.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus."
    Rybakin V., Stumpf M., Schulze A., Majoul I.V., Noegel A.A., Hasse A.
    FEBS Lett. 573:161-167(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4), VARIANT GLN-193.
    Tissue: Cerebellum, Hepatoma and Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Colon and Lymphoma.
  6. "Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi."
    Rybakin V., Gounko N.V., Spaete K., Hoening S., Majoul I.V., Duden R., Noegel A.A.
    J. Biol. Chem. 281:31070-31078(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AP1 COMPLEX.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob."
    Watanabe M., Suzuki T., Kim M., Abe Y., Yoshida Y., Sugano S., Yamamoto T.
    FEBS Lett. 585:65-70(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking."
    Yuan W.C., Lee Y.R., Lin S.Y., Chang L.Y., Tan Y.P., Hung C.C., Kuo J.C., Liu C.H., Lin M.Y., Xu M., Chen Z.J., Chen R.H.
    Mol. Cell 54:586-600(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, UBIQUITINATION AT LYS-472 AND LYS-680, MUTAGENESIS OF LYS-472 AND LYS-680, INTERACTION WITH EPS15.

Entry informationi

Entry nameiCORO7_HUMAN
AccessioniPrimary (citable) accession number: P57737
Secondary accession number(s): B4DFD6
, B4DL18, I3L416, Q17RK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: September 22, 2009
Last modified: June 8, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Reported to form a E3 ubiquitin-ligase complex and promote degradation of TOB1 (PubMed:21130766). Additional evidences are however required to confirm these data.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.