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Protein

Coronin-7

Gene

CORO7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.2 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

  • actin filament polymerization Source: UniProtKB
  • Golgi to endosome transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103426-MONOMER.
SignaLinkiP57737.

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-7
Short name:
Crn7
Alternative name(s):
70 kDa WD repeat tumor rejection antigen homolog
Gene namesi
Name:CORO7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26161. CORO7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB-SubCell
  • cytosol Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi472K → R: Impaired ability to regulate the anterograde Golgi to endosome transport. 1 Publication1
Mutagenesisi680K → R: Does not affect ability to regulate the anterograde Golgi to endosome transport. 1 Publication1

Organism-specific databases

DisGeNETi79585.
OpenTargetsiENSG00000103426.
ENSG00000262246.
ENSG00000278760.
ENSG00000282725.
PharmGKBiPA134910806.

Polymorphism and mutation databases

BioMutaiCORO7.
DMDMi259016200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509341 – 925Coronin-7Add BLAST925

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei462PhosphoserineBy similarity1
Modified residuei465PhosphoserineBy similarity1
Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki680Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei915PhosphoserineBy similarity1

Post-translational modificationi

The membrane-associated form is phosphorylated on tyrosine residues.By similarity
Ubiquitinated via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: 'Lys-33'-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP57737.
MaxQBiP57737.
PaxDbiP57737.
PeptideAtlasiP57737.
PRIDEiP57737.

PTM databases

iPTMnetiP57737.
PhosphoSitePlusiP57737.

Expressioni

Tissue specificityi

Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000262246.
CleanExiHS_CORO7.
ExpressionAtlasiP57737. baseline and differential.
GenevisibleiP57737. HS.

Organism-specific databases

HPAiHPA041657.
HPA053586.
HPA062721.

Interactioni

Subunit structurei

Interacts with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not AP1-positive endosomal membranes. Interacts (when ubiquitinated at Lys-472) with EPS15.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Tob1Q614713EBI-6916167,EBI-8527498From a different organism.

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122728. 28 interactors.
IntActiP57737. 13 interactors.
STRINGi9606.ENSP00000460885.

Structurei

3D structure databases

ProteinModelPortaliP57737.
SMRiP57737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati75 – 115WD 1Add BLAST41
Repeati124 – 163WD 2Add BLAST40
Repeati166 – 205WD 3Add BLAST40
Repeati209 – 253WD 4Add BLAST45
Repeati542 – 582WD 5Add BLAST41
Repeati592 – 632WD 6Add BLAST41
Repeati635 – 674WD 7Add BLAST40
Repeati728 – 768WD 8Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1445. Eukaryota.
KOG3442. Eukaryota.
ENOG410XPE7. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000006535.
HOVERGENiHBG051080.
InParanoidiP57737.
KOiK18619.
OMAiNDNEHFV.
OrthoDBiEOG091G01CQ.
PhylomeDBiP57737.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015505. Coronin.
IPR015048. DUF1899.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PfamiPF08953. DUF1899. 2 hits.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01166. DUF1899. 2 hits.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P57737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRFRVSKFR HTEARPPRRE SWISDIRAGT APSCRNHIKS SCSLIAFNSD
60 70 80 90 100
RPGVLGIVPL QGQGEDKRRV AHLGCHSDLV TDLDFSPFDD FLLATGSADR
110 120 130 140 150
TVKLWRLPGP GQALPSAPGV VLGPEDLPVE VLQFHPTSDG ILVSAAGTTV
160 170 180 190 200
KVWDAAKQQP LTELAAHGDL VQSAVWSRDG ALVGTACKDK QLRIFDPRTK
210 220 230 240 250
PRASQSTQAH ENSRDSRLAW MGTWEHLVST GFNQMREREV KLWDTRFFSS
260 270 280 290 300
ALASLTLDTS LGCLVPLLDP DSGLLVLAGK GERQLYCYEV VPQQPALSPV
310 320 330 340 350
TQCVLESVLR GAALVPRQAL AVMSCEVLRV LQLSDTAIVP IGYHVPRKAV
360 370 380 390 400
EFHEDLFPDT AGCVPATDPH SWWAGDNQQV QKVSLNPACR PHPSFTSCLV
410 420 430 440 450
PPAEPLPDTA QPAVMETPVG DADASEGFSS PPSSLTSPST PSSLGPSLSS
460 470 480 490 500
TSGIGTSPSL RSLQSLLGPS SKFRHAQGTV LHRDSHITNL KGLNLTTPGE
510 520 530 540 550
SDGFCANKLR VAVPLLSSGG QVAVLELRKP GRLPDTALPT LQNGAAVTDL
560 570 580 590 600
AWDPFDPHRL AVAGEDARIR LWRVPAEGLE EVLTTPETVL TGHTEKICSL
610 620 630 640 650
RFHPLAANVL ASSSYDLTVR IWDLQAGADR LKLQGHQDQI FSLAWSPDGQ
660 670 680 690 700
QLATVCKDGR VRVYRPRSGP EPLQEGPGPK GGRGARIVWV CDGRCLLVSG
710 720 730 740 750
FDSQSERQLL LYEAEALAGG PLAVLGLDVA PSTLLPSYDP DTGLVLLTGK
760 770 780 790 800
GDTRVFLYEL LPESPFFLEC NSFTSPDPHK GLVLLPKTEC DVREVELMRC
810 820 830 840 850
LRLRQSSLEP VAFRLPRVRK EFFQDDVFPD TAVIWEPVLS AEAWLQGANG
860 870 880 890 900
QPWLLSLQPP DMSPVSQAPR EAPARRAPSS AQYLEEKSDQ QKKEELLNAM
910 920
VAKLGNREDP LPQDSFEGVD EDEWD
Length:925
Mass (Da):100,605
Last modified:September 22, 2009 - v2
Checksum:iFC8680F8CCB409C0
GO
Isoform 2 (identifier: P57737-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-162: Missing.

Note: No experimental confirmation available.
Show »
Length:840
Mass (Da):91,655
Checksum:i0C11C60E67B6724C
GO
Isoform 3 (identifier: P57737-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     925-925: D → AKYLAQIIVM...DREKGQMPHT

Note: No experimental confirmation available.Curated
Show »
Length:1,048
Mass (Da):114,166
Checksum:iD5E7A7A7418F3DDC
GO
Isoform 4 (identifier: P57737-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-95: Missing.

Note: No experimental confirmation available.
Show »
Length:907
Mass (Da):98,579
Checksum:i7C3C5C07E5FA2C8C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti324S → G in BAB15211 (PubMed:14702039).Curated1
Sequence conflicti371S → G in BAB15211 (PubMed:14702039).Curated1
Sequence conflicti848A → T in BAB15211 (PubMed:14702039).Curated1
Isoform 3 (identifier: P57737-3)
Sequence conflicti1037Q → K in BC032732 (PubMed:15616553).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057585174A → V.Corresponds to variant rs17137007dbSNPEnsembl.1
Natural variantiVAR_057586193R → Q.1 PublicationCorresponds to variant rs3747579dbSNPEnsembl.1
Natural variantiVAR_057587257L → S.Corresponds to variant rs35357594dbSNPEnsembl.1
Natural variantiVAR_057588403A → T.Corresponds to variant rs9928967dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03815278 – 162Missing in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_04675278 – 95Missing in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_046022925D → AKYLAQIIVMGVQVVGRAFA RALRQEFAASRAAADARGRA GHRSAAASNLSGLSLQEAQQ ILNVSKLSPEEVQKNYEHLF KVNDKSVGGSFYLQSKVVRA KERLDEELKIQAQEDREKGQ MPHT in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025674 mRNA. Translation: BAB15211.1.
AK294045 mRNA. Translation: BAG57397.1.
AK296807 mRNA. Translation: BAG59380.1.
AC012676 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85307.1.
BC032732 mRNA. No translation available.
BC117289 mRNA. Translation: AAI17290.1.
BC117291 mRNA. Translation: AAI17292.1.
CCDSiCCDS10513.1. [P57737-1]
CCDS55982.1. [P57737-2]
CCDS58417.1. [P57737-4]
RefSeqiNP_001188401.1. NM_001201472.1. [P57737-4]
NP_001188402.1. NM_001201473.1. [P57737-2]
NP_078811.3. NM_024535.4. [P57737-1]
UniGeneiHs.437957.
Hs.739021.

Genome annotation databases

EnsembliENST00000251166; ENSP00000251166; ENSG00000262246. [P57737-1]
ENST00000537233; ENSP00000440460; ENSG00000262246. [P57737-4]
ENST00000574025; ENSP00000461702; ENSG00000262246. [P57737-2]
ENST00000614702; ENSP00000482646; ENSG00000282725. [P57737-1]
ENST00000617235; ENSP00000483187; ENSG00000282725. [P57737-4]
ENST00000631534; ENSP00000488867; ENSG00000282725. [P57737-2]
GeneIDi79585.
KEGGihsa:79585.
UCSCiuc002cwh.5. human. [P57737-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025674 mRNA. Translation: BAB15211.1.
AK294045 mRNA. Translation: BAG57397.1.
AK296807 mRNA. Translation: BAG59380.1.
AC012676 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85307.1.
BC032732 mRNA. No translation available.
BC117289 mRNA. Translation: AAI17290.1.
BC117291 mRNA. Translation: AAI17292.1.
CCDSiCCDS10513.1. [P57737-1]
CCDS55982.1. [P57737-2]
CCDS58417.1. [P57737-4]
RefSeqiNP_001188401.1. NM_001201472.1. [P57737-4]
NP_001188402.1. NM_001201473.1. [P57737-2]
NP_078811.3. NM_024535.4. [P57737-1]
UniGeneiHs.437957.
Hs.739021.

3D structure databases

ProteinModelPortaliP57737.
SMRiP57737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122728. 28 interactors.
IntActiP57737. 13 interactors.
STRINGi9606.ENSP00000460885.

PTM databases

iPTMnetiP57737.
PhosphoSitePlusiP57737.

Polymorphism and mutation databases

BioMutaiCORO7.
DMDMi259016200.

Proteomic databases

EPDiP57737.
MaxQBiP57737.
PaxDbiP57737.
PeptideAtlasiP57737.
PRIDEiP57737.

Protocols and materials databases

DNASUi79585.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251166; ENSP00000251166; ENSG00000262246. [P57737-1]
ENST00000537233; ENSP00000440460; ENSG00000262246. [P57737-4]
ENST00000574025; ENSP00000461702; ENSG00000262246. [P57737-2]
ENST00000614702; ENSP00000482646; ENSG00000282725. [P57737-1]
ENST00000617235; ENSP00000483187; ENSG00000282725. [P57737-4]
ENST00000631534; ENSP00000488867; ENSG00000282725. [P57737-2]
GeneIDi79585.
KEGGihsa:79585.
UCSCiuc002cwh.5. human. [P57737-1]

Organism-specific databases

CTDi79585.
DisGeNETi79585.
GeneCardsiCORO7.
H-InvDBHIX0012777.
HGNCiHGNC:26161. CORO7.
HPAiHPA041657.
HPA053586.
HPA062721.
MIMi611668. gene.
neXtProtiNX_P57737.
OpenTargetsiENSG00000103426.
ENSG00000262246.
ENSG00000278760.
ENSG00000282725.
PharmGKBiPA134910806.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1445. Eukaryota.
KOG3442. Eukaryota.
ENOG410XPE7. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000006535.
HOVERGENiHBG051080.
InParanoidiP57737.
KOiK18619.
OMAiNDNEHFV.
OrthoDBiEOG091G01CQ.
PhylomeDBiP57737.
TreeFamiTF314280.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103426-MONOMER.
SignaLinkiP57737.

Miscellaneous databases

GenomeRNAii79585.
PROiP57737.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000262246.
CleanExiHS_CORO7.
ExpressionAtlasiP57737. baseline and differential.
GenevisibleiP57737. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015505. Coronin.
IPR015048. DUF1899.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PfamiPF08953. DUF1899. 2 hits.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01166. DUF1899. 2 hits.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCORO7_HUMAN
AccessioniPrimary (citable) accession number: P57737
Secondary accession number(s): B4DFD6
, B4DL18, I3L416, Q17RK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Reported to form a E3 ubiquitin-ligase complex and promote degradation of TOB1 (PubMed:21130766). Additional evidences are however required to confirm these data.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.