Reviewed,
UniProtKB/Swiss-Prot P57735 (RAB25_HUMAN)
Last modified
June 16, 2009.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ras-related protein Rab-25 Alternative name(s): CATX-8 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 213 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May selectively regulate the apical recycling and/or transcytotic pathways By similarity. |
| Subunit structure | Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Ref.6 |
| Subcellular location | Cell membrane; Lipid-anchor; Cytoplasmic side Potential. |
| Sequence similarities | Belongs to the small GTPase superfamily. Rab family. |
| Sequence caution | The sequence AAF98238.1 differs from that shown. Reason: Frameshift at position 196. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Cellular component | Cell membrane Membrane |
| Ligand | GTP-binding Nucleotide-binding |
| PTM | Lipoprotein Methylation Prenylation |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from direct assay. Source: HPA plasma membraneInferred from direct assay. Source: HPA |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW identical protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| itself | 1 | EBI-1050500,EBI-1050500 | ||
| D2HGDH | Q8N465 | 1 | EBI-1050500,EBI-1053783 | |
| PKIG | Q9Y2B9 | 1 | EBI-1050500,EBI-1052231 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 210 | 210 | Ras-related protein Rab-25 | PRO_0000121215 | |||||||||||||||||||||||||||||||||
| Propeptide | 211 – 213 | 3 | Removed in mature form Potential | PRO_0000370821 | |||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 19 – 26 | 8 | GTP By similarity | ||||||||||||||||||||||||||||||||||
| Nucleotide binding | 67 – 71 | 5 | GTP By similarity | ||||||||||||||||||||||||||||||||||
| Nucleotide binding | 125 – 128 | 4 | GTP By similarity | ||||||||||||||||||||||||||||||||||
| Motif | 41 – 49 | 9 | Effector region By similarity | ||||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||||
| Modified residue | 210 | 1 | Cysteine methyl ester Potential | ||||||||||||||||||||||||||||||||||
| Lipidation | 209 | 1 | S-geranylgeranyl cysteine By similarity | ||||||||||||||||||||||||||||||||||
| Lipidation | 210 | 1 | S-geranylgeranyl cysteine By similarity | ||||||||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||||||
| Sequence conflict | 203 | 1 | P → L in AAF98238. Ref.1 | ||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||
| Beta strand | 10 – 20 | 11 | |||||||||||||||||||||||||||||||||||
| Helix | 25 – 34 | 10 | |||||||||||||||||||||||||||||||||||
| Beta strand | 45 – 56 | 12 | |||||||||||||||||||||||||||||||||||
| Beta strand | 59 – 69 | 11 | |||||||||||||||||||||||||||||||||||
| Helix | 78 – 82 | 5 | |||||||||||||||||||||||||||||||||||
| Beta strand | 87 – 93 | 7 | |||||||||||||||||||||||||||||||||||
| Helix | 97 – 101 | 5 | |||||||||||||||||||||||||||||||||||
| Helix | 103 – 111 | 9 | |||||||||||||||||||||||||||||||||||
| Beta strand | 119 – 125 | 7 | |||||||||||||||||||||||||||||||||||
| Helix | 127 – 132 | 6 | |||||||||||||||||||||||||||||||||||
| Helix | 137 – 146 | 10 | |||||||||||||||||||||||||||||||||||
| Beta strand | 150 – 154 | 5 | |||||||||||||||||||||||||||||||||||
| Turn | 156 – 158 | 3 | |||||||||||||||||||||||||||||||||||
| Helix | 162 – 178 | 17 | |||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation of novel genes from human colonic epithelial cells." Wang L., Kairo A., Gao Z.Q., Gao Z.P., Boman B.M. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon. |
| [2] | Yu L. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary, Pancreas and Skin. |
| [6] | "Identification and characterization of a family of Rab11-interacting proteins." Hales C.M., Griner R., Hobdy-Henderson K.C., Dorn M.C., Hardy D., Kumar R., Navarre J., Chan E.K.L., Lapierre L.A., Goldenring J.R. J. Biol. Chem. 276:39067-39075(2001) [PubMed: 11495908] [Abstract] Cited for: INTERACTION WITH RAB11FIP1; RAB11FIP2; RAB11FIP3 AND RAB11FIP4. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF083124 mRNA. Translation: AAF98238.1. Frameshift. AF274025 mRNA. Translation: AAM69362.1. Different initiation. AL355388 Genomic DNA. Translation: CAH72638.1. CH471121 Genomic DNA. Translation: EAW53003.1. BC004416 mRNA. Translation: AAH04416.1. BC009831 mRNA. Translation: AAH09831.1. BC033322 mRNA. Translation: AAH33322.1. | |||||||||||||
| IPI | IPI00027993. | ||||||||||||
| RefSeq | NP_065120.2. | ||||||||||||
| UniGene | Hs.632469 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P57735. 5 interactions. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P57735. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000132698. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 57111. | ||||||||||||
| KEGG | hsa:57111. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC01P154297. | ||||||||||||
| H-InvDB | HIX0001145. | ||||||||||||
| HGNC | HGNC:18238. RAB25. | ||||||||||||
| HPA | HPA010872. | ||||||||||||
| PharmGKB | PA34115. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOVERGEN | P57735. | ||||||||||||
| OMA | P57735. EDDYNFV. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P57735. | ||||||||||||
| Bgee | P57735. | ||||||||||||
| CleanEx | HS_RAB25. | ||||||||||||
| GermOnline | ENSG00000132698. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR003579. GTPase_Rab. IPR015595. Rab11. IPR013753. Ras. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view] | ||||||||||||
| PANTHER | PTHR11708:SF213. Rab11. 1 hit. | ||||||||||||
| Pfam | PF00071. Ras. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00449. RASTRNSFRMNG. | ||||||||||||
| SMART | SM00175. RAB. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR00231. small_GTP. 1 hit. | ||||||||||||
| PROSITE | PS51419. RAB. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 62967. | ||||||||||||
Entry information
| Entry name | RAB25_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P57735 Secondary accession number(s): Q5VYA2 Q9BT12 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


