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Protein

Caspase recruitment domain-containing protein 18

Gene

CARD18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.1 Publication

GO - Molecular functioni

  • CARD domain binding Source: UniProtKB
  • caspase binding Source: UniProtKB
  • cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: GO_Central
  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • execution phase of apoptosis Source: GO_Central
  • inflammatory response Source: UniProtKB
  • inhibition of cysteine-type endopeptidase activity Source: UniProtKB
  • negative regulation of interleukin-1 beta secretion Source: UniProtKB
  • negative regulation of protein binding Source: UniProtKB
  • regulation of apoptotic process Source: InterPro

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 18
Alternative name(s):
Caspase-1 inhibitor Iceberg
Gene namesi
Name:CARD18
Synonyms:ICEBERG
ORF Names:UNQ5804/PRO19611
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28861. CARD18.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • protein complex Source: UniProtKB

Pathology & Biotechi

Organism-specific databases

DisGeNETi59082.
OpenTargetsiENSG00000255501.
PharmGKBiPA164717642.

Polymorphism and mutation databases

BioMutaiCARD18.
DMDMi12230142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841451 – 90Caspase recruitment domain-containing protein 18Add BLAST90

Proteomic databases

PaxDbiP57730.
PeptideAtlasiP57730.
PRIDEiP57730.

PTM databases

iPTMnetiP57730.
PhosphoSitePlusiP57730.

Expressioni

Tissue specificityi

Primarily expressed in the heart and placenta.1 Publication

Inductioni

Up-regulated in response to TNF and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000255501.
CleanExiHS_CARD18.
ExpressionAtlasiP57730. baseline and differential.
GenevisibleiP57730. HS.

Organism-specific databases

HPAiHPA038582.

Interactioni

Subunit structurei

Interacts with pro-CASP1. Interacts with CARD8.2 Publications

GO - Molecular functioni

  • CARD domain binding Source: UniProtKB
  • caspase binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-41317N.
MINTiMINT-231364.
STRINGi9606.ENSP00000436691.

Structurei

Secondary structure

190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 8Combined sources4
Helixi10 – 14Combined sources5
Helixi19 – 32Combined sources14
Helixi37 – 44Combined sources8
Helixi50 – 63Combined sources14
Helixi66 – 79Combined sources14
Helixi83 – 87Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DGNNMR-A2-90[»]
ProteinModelPortaliP57730.
SMRiP57730.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57730.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90CARDPROSITE-ProRule annotationAdd BLAST90

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00510000049857.
HOVERGENiHBG006113.
InParanoidiP57730.
KOiK12806.
OMAiEDMNKVR.
OrthoDBiEOG091G10JS.
PhylomeDBiP57730.

Family and domain databases

InterProiView protein in InterPro
IPR001315. CARD.
IPR011029. DEATH-like_dom.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50209. CARD. 1 hit.

Sequencei

Sequence statusi: Complete.

P57730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV
60 70 80 90
MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH
Length:90
Mass (Da):10,138
Last modified:January 11, 2001 - v1
Checksum:i7E74C74263367101
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208005 mRNA. Translation: AAG23528.1.
AY358231 mRNA. Translation: AAQ88598.1.
BC131610 mRNA. Translation: AAI31611.1.
CCDSiCCDS53705.1.
RefSeqiNP_067546.1. NM_021571.3.
UniGeneiHs.56279.

Genome annotation databases

EnsembliENST00000530950; ENSP00000436691; ENSG00000255501.
GeneIDi59082.
KEGGihsa:59082.
UCSCiuc021qpy.2. human.

Similar proteinsi

Entry informationi

Entry nameiCAR18_HUMAN
AccessioniPrimary (citable) accession number: P57730
Secondary accession number(s): A2RRF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: August 30, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references