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P57730 (CAR18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caspase recruitment domain-containing protein 18
Alternative name(s):
Caspase-1 inhibitor Iceberg
Gene names
Name:CARD18
Synonyms:ICEBERG
ORF Names:UNQ5804/PRO19611
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length90 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B. Ref.1

Subunit structure

Interacts with pro-CASP1. Interacts with CARD8. Ref.1 Ref.4

Tissue specificity

Primarily expressed in the heart and placenta. Ref.1

Induction

Up-regulated in response to TNF and bacterial lipopolysaccharides (LPS). Ref.1

Sequence similarities

Contains 1 CARD domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9090Caspase recruitment domain-containing protein 18
PRO_0000084145

Regions

Domain1 – 9090CARD

Secondary structure

............... 90
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P57730 [UniParc].

Last modified January 11, 2001. Version 1.
Checksum: 7E74C74263367101

FASTA9010,138
        10         20         30         40         50         60 
MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV MDKARVLIDL 

        70         80         90 
VTGKGPKSCC KFIKHLCEED PQLASKMGLH 

« Hide

References

« Hide 'large scale' references
[1]"ICEBERG: a novel inhibitor of interleukin-1beta generation."
Humke E.W., Shriver S.K., Starovasnik M.A., Fairbrother W.J., Dixit V.M.
Cell 103:99-111(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], STRUCTURE BY NMR, FUNCTION, INTERACTION WITH CASP1, INDUCTION, TISSUE SPECIFICITY.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis."
Razmara M., Srinivasula S.M., Wang L., Poyet J.-L., Geddes B.J., DiStefano P.S., Bertin J., Alnemri E.S.
J. Biol. Chem. 277:13952-13958(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CARD8.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF208005 mRNA. Translation: AAG23528.1.
AY358231 mRNA. Translation: AAQ88598.1.
BC131610 mRNA. Translation: AAI31611.1.
RefSeqNP_067546.1. NM_021571.3.
UniGeneHs.56279.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1DGNNMR-A2-90[»]
ProteinModelPortalP57730.
SMRP57730. Positions 2-90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-231364.

PTM databases

PhosphoSiteP57730.

Polymorphism databases

DMDM12230142.

Proteomic databases

PRIDEP57730.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000530950; ENSP00000436691; ENSG00000255501.
GeneID59082.
KEGGhsa:59082.
UCSCuc021qpy.1. human.

Organism-specific databases

CTD59082.
GeneCardsGC11M105008.
HGNCHGNC:28861. CARD18.
HPAHPA038582.
MIM605354. gene.
neXtProtNX_P57730.
PharmGKBPA164717642.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG006113.
InParanoidP57730.
KOK12806.
OMAISQEDMN.
OrthoDBEOG7J1812.
PhylomeDBP57730.

Gene expression databases

ArrayExpressP57730.
BgeeP57730.
CleanExHS_CARD18.
GenevestigatorP57730.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
InterProIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamPF00619. CARD. 1 hit.
[Graphical view]
SMARTSM00114. CARD. 1 hit.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
PROSITEPS50209. CARD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP57730.
GenomeRNAi59082.
NextBio65139.
PROP57730.
SOURCESearch...

Entry information

Entry nameCAR18_HUMAN
AccessionPrimary (citable) accession number: P57730
Secondary accession number(s): A2RRF8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM