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Protein

Caspase recruitment domain-containing protein 18

Gene

CARD18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.1 Publication

GO - Molecular functioni

GO - Biological processi

  • inflammatory response Source: UniProtKB
  • regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 18
Alternative name(s):
Caspase-1 inhibitor Iceberg
Gene namesi
Name:CARD18
Synonyms:ICEBERG
ORF Names:UNQ5804/PRO19611
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28861. CARD18.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717642.

Polymorphism and mutation databases

BioMutaiCARD18.
DMDMi12230142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9090Caspase recruitment domain-containing protein 18PRO_0000084145Add
BLAST

Proteomic databases

PRIDEiP57730.

PTM databases

PhosphoSiteiP57730.

Expressioni

Tissue specificityi

Primarily expressed in the heart and placenta.1 Publication

Inductioni

Up-regulated in response to TNF and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiP57730.
CleanExiHS_CARD18.
ExpressionAtlasiP57730. baseline and differential.
GenevestigatoriP57730.

Organism-specific databases

HPAiHPA038582.

Interactioni

Subunit structurei

Interacts with pro-CASP1. Interacts with CARD8.2 Publications

Protein-protein interaction databases

MINTiMINT-231364.

Structurei

Secondary structure

1
90
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 84Combined sources
Helixi10 – 145Combined sources
Helixi19 – 3214Combined sources
Helixi37 – 448Combined sources
Helixi50 – 6314Combined sources
Helixi66 – 7914Combined sources
Helixi83 – 875Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DGNNMR-A2-90[»]
ProteinModelPortaliP57730.
SMRiP57730. Positions 2-90.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57730.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9090CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00510000049857.
HOVERGENiHBG006113.
InParanoidiP57730.
KOiK12806.
OMAiEDMNKVR.
OrthoDBiEOG7J1812.
PhylomeDBiP57730.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV
60 70 80 90
MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH
Length:90
Mass (Da):10,138
Last modified:January 11, 2001 - v1
Checksum:i7E74C74263367101
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208005 mRNA. Translation: AAG23528.1.
AY358231 mRNA. Translation: AAQ88598.1.
BC131610 mRNA. Translation: AAI31611.1.
CCDSiCCDS53705.1.
RefSeqiNP_067546.1. NM_021571.3.
UniGeneiHs.56279.

Genome annotation databases

EnsembliENST00000530950; ENSP00000436691; ENSG00000255501.
GeneIDi59082.
KEGGihsa:59082.
UCSCiuc021qpy.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208005 mRNA. Translation: AAG23528.1.
AY358231 mRNA. Translation: AAQ88598.1.
BC131610 mRNA. Translation: AAI31611.1.
CCDSiCCDS53705.1.
RefSeqiNP_067546.1. NM_021571.3.
UniGeneiHs.56279.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DGNNMR-A2-90[»]
ProteinModelPortaliP57730.
SMRiP57730. Positions 2-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-231364.

PTM databases

PhosphoSiteiP57730.

Polymorphism and mutation databases

BioMutaiCARD18.
DMDMi12230142.

Proteomic databases

PRIDEiP57730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000530950; ENSP00000436691; ENSG00000255501.
GeneIDi59082.
KEGGihsa:59082.
UCSCiuc021qpy.1. human.

Organism-specific databases

CTDi59082.
GeneCardsiGC11M105008.
HGNCiHGNC:28861. CARD18.
HPAiHPA038582.
MIMi605354. gene.
neXtProtiNX_P57730.
PharmGKBiPA164717642.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00510000049857.
HOVERGENiHBG006113.
InParanoidiP57730.
KOiK12806.
OMAiEDMNKVR.
OrthoDBiEOG7J1812.
PhylomeDBiP57730.

Miscellaneous databases

EvolutionaryTraceiP57730.
GenomeRNAii59082.
NextBioi65139.
PROiP57730.
SOURCEiSearch...

Gene expression databases

BgeeiP57730.
CleanExiHS_CARD18.
ExpressionAtlasiP57730. baseline and differential.
GenevestigatoriP57730.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ICEBERG: a novel inhibitor of interleukin-1beta generation."
    Humke E.W., Shriver S.K., Starovasnik M.A., Fairbrother W.J., Dixit V.M.
    Cell 103:99-111(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], STRUCTURE BY NMR, FUNCTION, INTERACTION WITH CASP1, INDUCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis."
    Razmara M., Srinivasula S.M., Wang L., Poyet J.-L., Geddes B.J., DiStefano P.S., Bertin J., Alnemri E.S.
    J. Biol. Chem. 277:13952-13958(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CARD8.

Entry informationi

Entry nameiCAR18_HUMAN
AccessioniPrimary (citable) accession number: P57730
Secondary accession number(s): A2RRF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: April 29, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.