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P57730

- CAR18_HUMAN

UniProt

P57730 - CAR18_HUMAN

Protein

Caspase recruitment domain-containing protein 18

Gene

CARD18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.1 Publication

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. inflammatory response Source: UniProtKB
    2. regulation of apoptotic process Source: InterPro

    Keywords - Molecular functioni

    Protease inhibitor, Thiol protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase recruitment domain-containing protein 18
    Alternative name(s):
    Caspase-1 inhibitor Iceberg
    Gene namesi
    Name:CARD18
    Synonyms:ICEBERG
    ORF Names:UNQ5804/PRO19611
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:28861. CARD18.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164717642.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9090Caspase recruitment domain-containing protein 18PRO_0000084145Add
    BLAST

    Proteomic databases

    PRIDEiP57730.

    PTM databases

    PhosphoSiteiP57730.

    Expressioni

    Tissue specificityi

    Primarily expressed in the heart and placenta.1 Publication

    Inductioni

    Up-regulated in response to TNF and bacterial lipopolysaccharides (LPS).1 Publication

    Gene expression databases

    ArrayExpressiP57730.
    BgeeiP57730.
    CleanExiHS_CARD18.
    GenevestigatoriP57730.

    Organism-specific databases

    HPAiHPA038582.

    Interactioni

    Subunit structurei

    Interacts with pro-CASP1. Interacts with CARD8.2 Publications

    Protein-protein interaction databases

    MINTiMINT-231364.

    Structurei

    Secondary structure

    1
    90
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 84
    Helixi10 – 145
    Helixi19 – 3214
    Helixi37 – 448
    Helixi50 – 6314
    Helixi66 – 7914
    Helixi83 – 875

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1DGNNMR-A2-90[»]
    ProteinModelPortaliP57730.
    SMRiP57730. Positions 2-90.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP57730.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9090CARDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CARD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG006113.
    InParanoidiP57730.
    KOiK12806.
    OMAiISQEDMN.
    OrthoDBiEOG7J1812.
    PhylomeDBiP57730.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    [Graphical view]
    SMARTiSM00114. CARD. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57730-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV   50
    MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH 90
    Length:90
    Mass (Da):10,138
    Last modified:January 11, 2001 - v1
    Checksum:i7E74C74263367101
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208005 mRNA. Translation: AAG23528.1.
    AY358231 mRNA. Translation: AAQ88598.1.
    BC131610 mRNA. Translation: AAI31611.1.
    CCDSiCCDS53705.1.
    RefSeqiNP_067546.1. NM_021571.3.
    UniGeneiHs.56279.

    Genome annotation databases

    EnsembliENST00000530950; ENSP00000436691; ENSG00000255501.
    GeneIDi59082.
    KEGGihsa:59082.
    UCSCiuc021qpy.1. human.

    Polymorphism databases

    DMDMi12230142.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208005 mRNA. Translation: AAG23528.1 .
    AY358231 mRNA. Translation: AAQ88598.1 .
    BC131610 mRNA. Translation: AAI31611.1 .
    CCDSi CCDS53705.1.
    RefSeqi NP_067546.1. NM_021571.3.
    UniGenei Hs.56279.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1DGN NMR - A 2-90 [» ]
    ProteinModelPortali P57730.
    SMRi P57730. Positions 2-90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-231364.

    PTM databases

    PhosphoSitei P57730.

    Polymorphism databases

    DMDMi 12230142.

    Proteomic databases

    PRIDEi P57730.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000530950 ; ENSP00000436691 ; ENSG00000255501 .
    GeneIDi 59082.
    KEGGi hsa:59082.
    UCSCi uc021qpy.1. human.

    Organism-specific databases

    CTDi 59082.
    GeneCardsi GC11M105008.
    HGNCi HGNC:28861. CARD18.
    HPAi HPA038582.
    MIMi 605354. gene.
    neXtProti NX_P57730.
    PharmGKBi PA164717642.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG006113.
    InParanoidi P57730.
    KOi K12806.
    OMAi ISQEDMN.
    OrthoDBi EOG7J1812.
    PhylomeDBi P57730.

    Miscellaneous databases

    EvolutionaryTracei P57730.
    GenomeRNAii 59082.
    NextBioi 65139.
    PROi P57730.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P57730.
    Bgeei P57730.
    CleanExi HS_CARD18.
    Genevestigatori P57730.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    [Graphical view ]
    SMARTi SM00114. CARD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ICEBERG: a novel inhibitor of interleukin-1beta generation."
      Humke E.W., Shriver S.K., Starovasnik M.A., Fairbrother W.J., Dixit V.M.
      Cell 103:99-111(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], STRUCTURE BY NMR, FUNCTION, INTERACTION WITH CASP1, INDUCTION, TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis."
      Razmara M., Srinivasula S.M., Wang L., Poyet J.-L., Geddes B.J., DiStefano P.S., Bertin J., Alnemri E.S.
      J. Biol. Chem. 277:13952-13958(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CARD8.

    Entry informationi

    Entry nameiCAR18_HUMAN
    AccessioniPrimary (citable) accession number: P57730
    Secondary accession number(s): A2RRF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3