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P57729

- RAB38_HUMAN

UniProt

P57729 - RAB38_HUMAN

Protein

Ras-related protein Rab-38

Gene

RAB38

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei208 – 2081Not methylated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 238GTPBy similarity
    Nucleotide bindingi65 – 695GTPBy similarity
    Nucleotide bindingi127 – 1304GTPBy similarity

    GO - Molecular functioni

    1. AP-1 adaptor complex binding Source: BHF-UCL
    2. AP-3 adaptor complex binding Source: BHF-UCL
    3. GTPase activity Source: UniProtKB
    4. GTP binding Source: UniProtKB
    5. GTP-dependent protein binding Source: BHF-UCL
    6. protein binding Source: BHF-UCL
    7. protein complex binding Source: BHF-UCL

    GO - Biological processi

    1. endosome to melanosome transport Source: BHF-UCL
    2. GTP catabolic process Source: GOC
    3. melanosome organization Source: BHF-UCL
    4. phagosome acidification Source: UniProtKB
    5. platelet dense granule organization Source: Ensembl
    6. protein localization to membrane Source: BHF-UCL
    7. protein transport Source: UniProtKB
    8. small GTPase mediated signal transduction Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-38
    Alternative name(s):
    Melanoma antigen NY-MEL-1
    Gene namesi
    Name:RAB38
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:9776. RAB38.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Melanosome. Cytoplasmic vesiclephagosome. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Recruited to phagosomes containing S.aureus or M.tuberculosis.

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. early endosome Source: BHF-UCL
    3. melanosome Source: BHF-UCL
    4. membrane Source: BHF-UCL
    5. phagocytic vesicle Source: UniProtKB
    6. phagocytic vesicle membrane Source: UniProtKB-SubCell
    7. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34129.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Ras-related protein Rab-38PRO_0000121251Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi205 – 2051S-palmitoyl cysteineSequence Analysis
    Lipidationi208 – 2081S-geranylgeranyl cysteine1 Publication

    Post-translational modificationi

    Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated.1 Publication

    Keywords - PTMi

    Lipoprotein, Palmitate, Prenylation

    Proteomic databases

    MaxQBiP57729.
    PaxDbiP57729.
    PRIDEiP57729.

    PTM databases

    PhosphoSiteiP57729.

    Expressioni

    Tissue specificityi

    Expressed in melanocytes.

    Gene expression databases

    BgeeiP57729.
    CleanExiHS_RAB38.
    GenevestigatoriP57729.

    Interactioni

    Protein-protein interaction databases

    BioGridi117198. 2 interactions.
    DIPiDIP-60520N.
    STRINGi9606.ENSP00000243662.

    Structurei

    3D structure databases

    ProteinModelPortaliP57729.
    SMRiP57729. Positions 7-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi38 – 469Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP57729.
    KOiK07923.
    OMAiPNYRATI.
    OrthoDBiEOG78M02X.
    PhylomeDBiP57729.
    TreeFamiTF324491.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57729-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAPHKEHLY KLLVIGDLGV GKTSIIKRYV HQNFSSHYRA TIGVDFALKV    50
    LHWDPETVVR LQLWDIAGQE RFGNMTRVYY REAMGAFIVF DVTRPATFEA 100
    VAKWKNDLDS KLSLPNGKPV SVVLLANKCD QGKDVLMNNG LKMDQFCKEH 150
    GFVGWFETSA KENINIDEAS RCLVKHILAN ECDLMESIEP DVVKPHLTST 200
    KVASCSGCAK S 211
    Length:211
    Mass (Da):23,712
    Last modified:January 11, 2001 - v1
    Checksum:i0D16B42A1B237539
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti111 – 1111K → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036415

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF235022 mRNA. Translation: AAG30731.1.
    BT009842 mRNA. Translation: AAP88844.1.
    DQ178619 Genomic DNA. Translation: ABA03166.1.
    BC015808 mRNA. Translation: AAH15808.1.
    CCDSiCCDS8281.1.
    RefSeqiNP_071732.1. NM_022337.2.
    UniGeneiHs.591975.

    Genome annotation databases

    EnsembliENST00000243662; ENSP00000243662; ENSG00000123892.
    GeneIDi23682.
    KEGGihsa:23682.
    UCSCiuc001pcj.2. human.

    Polymorphism databases

    DMDMi12230516.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF235022 mRNA. Translation: AAG30731.1 .
    BT009842 mRNA. Translation: AAP88844.1 .
    DQ178619 Genomic DNA. Translation: ABA03166.1 .
    BC015808 mRNA. Translation: AAH15808.1 .
    CCDSi CCDS8281.1.
    RefSeqi NP_071732.1. NM_022337.2.
    UniGenei Hs.591975.

    3D structure databases

    ProteinModelPortali P57729.
    SMRi P57729. Positions 7-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117198. 2 interactions.
    DIPi DIP-60520N.
    STRINGi 9606.ENSP00000243662.

    PTM databases

    PhosphoSitei P57729.

    Polymorphism databases

    DMDMi 12230516.

    Proteomic databases

    MaxQBi P57729.
    PaxDbi P57729.
    PRIDEi P57729.

    Protocols and materials databases

    DNASUi 23682.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000243662 ; ENSP00000243662 ; ENSG00000123892 .
    GeneIDi 23682.
    KEGGi hsa:23682.
    UCSCi uc001pcj.2. human.

    Organism-specific databases

    CTDi 23682.
    GeneCardsi GC11M087846.
    HGNCi HGNC:9776. RAB38.
    MIMi 606281. gene.
    neXtProti NX_P57729.
    PharmGKBi PA34129.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P57729.
    KOi K07923.
    OMAi PNYRATI.
    OrthoDBi EOG78M02X.
    PhylomeDBi P57729.
    TreeFami TF324491.

    Miscellaneous databases

    GeneWikii RAB38.
    GenomeRNAii 23682.
    NextBioi 46557.
    PROi P57729.
    SOURCEi Search...

    Gene expression databases

    Bgeei P57729.
    CleanExi HS_RAB38.
    Genevestigatori P57729.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library."
      Jaeger D., Stockert E., Jaeger E., Guere A.O., Scanlan M.J., Knuth A., Old L.J., Chen Y.-T.
      Cancer Res. 60:3584-3591(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. SeattleSNPs variation discovery resource
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    7. "Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation."
      Leung K.F., Baron R., Ali B.R., Magee A.I., Seabra M.C.
      J. Biol. Chem. 282:1487-1497(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ISOPRENYLATION AT CYS-208.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
      Seto S., Tsujimura K., Koide Y.
      Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-111.

    Entry informationi

    Entry nameiRAB38_HUMAN
    AccessioniPrimary (citable) accession number: P57729
    Secondary accession number(s): Q53XK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3