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P57729

- RAB38_HUMAN

UniProt

P57729 - RAB38_HUMAN

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Protein

Ras-related protein Rab-38

Gene
RAB38
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei208 – 2081Not methylated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238GTP By similarity
Nucleotide bindingi65 – 695GTP By similarity
Nucleotide bindingi127 – 1304GTP By similarity

GO - Molecular functioni

  1. AP-1 adaptor complex binding Source: BHF-UCL
  2. AP-3 adaptor complex binding Source: BHF-UCL
  3. GTPase activity Source: UniProtKB
  4. GTP binding Source: UniProtKB
  5. GTP-dependent protein binding Source: BHF-UCL
  6. protein binding Source: BHF-UCL
  7. protein complex binding Source: BHF-UCL

GO - Biological processi

  1. endosome to melanosome transport Source: BHF-UCL
  2. GTP catabolic process Source: GOC
  3. melanosome organization Source: BHF-UCL
  4. phagosome acidification Source: UniProtKB
  5. platelet dense granule organization Source: Ensembl
  6. protein localization to membrane Source: BHF-UCL
  7. protein transport Source: UniProtKB
  8. small GTPase mediated signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-38
Alternative name(s):
Melanoma antigen NY-MEL-1
Gene namesi
Name:RAB38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9776. RAB38.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side Reviewed prediction. Melanosome. Cytoplasmic vesiclephagosome. Cytoplasmic vesiclephagosome membrane; Lipid-anchor; Cytoplasmic side By similarity
Note: Recruited to phagosomes containing S.aureus or M.tuberculosis.3 Publications

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. early endosome Source: BHF-UCL
  3. melanosome Source: BHF-UCL
  4. membrane Source: BHF-UCL
  5. phagocytic vesicle Source: UniProtKB
  6. phagocytic vesicle membrane Source: UniProtKB-SubCell
  7. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Ras-related protein Rab-38PRO_0000121251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi205 – 2051S-palmitoyl cysteine Reviewed prediction
Lipidationi208 – 2081S-geranylgeranyl cysteine Inferred

Post-translational modificationi

Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated.

Keywords - PTMi

Lipoprotein, Palmitate, Prenylation

Proteomic databases

MaxQBiP57729.
PaxDbiP57729.
PRIDEiP57729.

PTM databases

PhosphoSiteiP57729.

Expressioni

Tissue specificityi

Expressed in melanocytes.

Gene expression databases

BgeeiP57729.
CleanExiHS_RAB38.
GenevestigatoriP57729.

Interactioni

Protein-protein interaction databases

BioGridi117198. 2 interactions.
DIPiDIP-60520N.
STRINGi9606.ENSP00000243662.

Structurei

3D structure databases

ProteinModelPortaliP57729.
SMRiP57729. Positions 7-183.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 469Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP57729.
KOiK07923.
OMAiPNYRATI.
OrthoDBiEOG78M02X.
PhylomeDBiP57729.
TreeFamiTF324491.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57729-1 [UniParc]FASTAAdd to Basket

« Hide

MQAPHKEHLY KLLVIGDLGV GKTSIIKRYV HQNFSSHYRA TIGVDFALKV    50
LHWDPETVVR LQLWDIAGQE RFGNMTRVYY REAMGAFIVF DVTRPATFEA 100
VAKWKNDLDS KLSLPNGKPV SVVLLANKCD QGKDVLMNNG LKMDQFCKEH 150
GFVGWFETSA KENINIDEAS RCLVKHILAN ECDLMESIEP DVVKPHLTST 200
KVASCSGCAK S 211
Length:211
Mass (Da):23,712
Last modified:January 11, 2001 - v1
Checksum:i0D16B42A1B237539
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111K → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036415

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF235022 mRNA. Translation: AAG30731.1.
BT009842 mRNA. Translation: AAP88844.1.
DQ178619 Genomic DNA. Translation: ABA03166.1.
BC015808 mRNA. Translation: AAH15808.1.
CCDSiCCDS8281.1.
RefSeqiNP_071732.1. NM_022337.2.
UniGeneiHs.591975.

Genome annotation databases

EnsembliENST00000243662; ENSP00000243662; ENSG00000123892.
GeneIDi23682.
KEGGihsa:23682.
UCSCiuc001pcj.2. human.

Polymorphism databases

DMDMi12230516.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF235022 mRNA. Translation: AAG30731.1 .
BT009842 mRNA. Translation: AAP88844.1 .
DQ178619 Genomic DNA. Translation: ABA03166.1 .
BC015808 mRNA. Translation: AAH15808.1 .
CCDSi CCDS8281.1.
RefSeqi NP_071732.1. NM_022337.2.
UniGenei Hs.591975.

3D structure databases

ProteinModelPortali P57729.
SMRi P57729. Positions 7-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117198. 2 interactions.
DIPi DIP-60520N.
STRINGi 9606.ENSP00000243662.

PTM databases

PhosphoSitei P57729.

Polymorphism databases

DMDMi 12230516.

Proteomic databases

MaxQBi P57729.
PaxDbi P57729.
PRIDEi P57729.

Protocols and materials databases

DNASUi 23682.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243662 ; ENSP00000243662 ; ENSG00000123892 .
GeneIDi 23682.
KEGGi hsa:23682.
UCSCi uc001pcj.2. human.

Organism-specific databases

CTDi 23682.
GeneCardsi GC11M087846.
HGNCi HGNC:9776. RAB38.
MIMi 606281. gene.
neXtProti NX_P57729.
PharmGKBi PA34129.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P57729.
KOi K07923.
OMAi PNYRATI.
OrthoDBi EOG78M02X.
PhylomeDBi P57729.
TreeFami TF324491.

Miscellaneous databases

GeneWikii RAB38.
GenomeRNAii 23682.
NextBioi 46557.
PROi P57729.
SOURCEi Search...

Gene expression databases

Bgeei P57729.
CleanExi HS_RAB38.
Genevestigatori P57729.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library."
    Jaeger D., Stockert E., Jaeger E., Guere A.O., Scanlan M.J., Knuth A., Old L.J., Chen Y.-T.
    Cancer Res. 60:3584-3591(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. SeattleSNPs variation discovery resource
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  7. "Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation."
    Leung K.F., Baron R., Ali B.R., Magee A.I., Seabra M.C.
    J. Biol. Chem. 282:1487-1497(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ISOPRENYLATION AT CYS-208.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
    Seto S., Tsujimura K., Koide Y.
    Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-111.

Entry informationi

Entry nameiRAB38_HUMAN
AccessioniPrimary (citable) accession number: P57729
Secondary accession number(s): Q53XK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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