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Protein

Poly(rC)-binding protein 4

Gene

PCBP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • mRNA 3'-UTR binding Source: MGI
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6804116. TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
R-HSA-69895. Transcriptional activation of cell cycle inhibitor p21.
SignaLinkiP57723.

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(rC)-binding protein 4
Alternative name(s):
Alpha-CP4
Gene namesi
Name:PCBP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8652. PCBP4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32991.

Polymorphism and mutation databases

BioMutaiPCBP4.
DMDMi12230429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Poly(rC)-binding protein 4PRO_0000050094Add
BLAST

Proteomic databases

EPDiP57723.
MaxQBiP57723.
PaxDbiP57723.
PeptideAtlasiP57723.
PRIDEiP57723.

PTM databases

iPTMnetiP57723.
PhosphoSiteiP57723.

Expressioni

Gene expression databases

BgeeiP57723.
CleanExiHS_PCBP4.
ExpressionAtlasiP57723. baseline and differential.
GenevisibleiP57723. HS.

Interactioni

Protein-protein interaction databases

BioGridi121351. 10 interactions.
IntActiP57723. 4 interactions.
MINTiMINT-2873350.
STRINGi9606.ENSP00000322341.

Structurei

3D structure databases

ProteinModelPortaliP57723.
SMRiP57723. Positions 15-173, 240-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 6751KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini101 – 15454KH 2PROSITE-ProRule annotationAdd
BLAST
Domaini241 – 29353KH 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2190. Eukaryota.
ENOG410XNN8. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000182823.
HOVERGENiHBG053520.
InParanoidiP57723.
KOiK13162.
OMAiQYGHPEH.
OrthoDBiEOG7P02J4.
PhylomeDBiP57723.
TreeFamiTF318292.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR033088. PCBP4.
[Graphical view]
PANTHERiPTHR10288:SF166. PTHR10288:SF166. 1 hit.
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P57723-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSDGGLEE EPELSITLTL RMLMHGKEVG SIIGKKGETV KRIREQSSAR
60 70 80 90 100
ITISEGSCPE RITTITGSTA AVFHAVSMIA FKLDEDLCAA PANGGNVSRP
110 120 130 140 150
PVTLRLVIPA SQCGSLIGKA GTKIKEIRET TGAQVQVAGD LLPNSTERAV
160 170 180 190 200
TVSGVPDAII LCVRQICAVI LESPPKGATI PYHPSLSLGT VLLSANQGFS
210 220 230 240 250
VQGQYGAVTP AEVTKLQQLS SHAVPFATPS VVPGLDPGTQ TSSQEFLVPN
260 270 280 290 300
DLIGCVIGRQ GSKISEIRQM SGAHIKIGNQ AEGAGERHVT ITGSPVSIAL
310 320 330 340 350
AQYLITACLE TAKSTSGGTP SSAPADLPAP FSPPLTALPT APPGLLGTPY
360 370 380 390 400
AISLSNFIGL KPMPFLALPP ASPGPPPGLA AYTAKMAAAN GSKKAERQKF

SPY
Length:403
Mass (Da):41,482
Last modified:January 11, 2001 - v1
Checksum:i3D99F762A9471265
GO
Isoform 2 (identifier: P57723-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-172: Missing.

Note: No experimental confirmation available.
Show »
Length:360
Mass (Da):37,078
Checksum:i97B90BEC8EB3139A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti198 – 1981G → S.
Corresponds to variant rs323872 [ dbSNP | Ensembl ].
VAR_049681

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei130 – 17243Missing in isoform 2. 1 PublicationVSP_010016Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176330 mRNA. Translation: AAG09241.1.
AK023993 mRNA. Translation: BAB14761.1.
BC003008 mRNA. Translation: AAH03008.1.
BC004153 mRNA. Translation: AAH04153.1.
BC017098 mRNA. Translation: AAH17098.1.
CCDSiCCDS2839.1. [P57723-1]
CCDS2840.2. [P57723-2]
RefSeqiNP_001167571.1. NM_001174100.1. [P57723-1]
NP_065151.2. NM_020418.3. [P57723-2]
NP_127501.1. NM_033008.2. [P57723-1]
NP_127503.1. NM_033010.2. [P57723-1]
XP_005265388.1. XM_005265331.2. [P57723-1]
XP_006713331.1. XM_006713268.2. [P57723-1]
XP_006713332.1. XM_006713269.1. [P57723-1]
XP_006713333.1. XM_006713270.1. [P57723-2]
UniGeneiHs.20930.

Genome annotation databases

EnsembliENST00000322099; ENSP00000322341; ENSG00000090097. [P57723-1]
ENST00000355852; ENSP00000348111; ENSG00000090097. [P57723-1]
ENST00000428823; ENSP00000395030; ENSG00000090097. [P57723-2]
ENST00000461554; ENSP00000417196; ENSG00000090097. [P57723-1]
ENST00000484633; ENSP00000417100; ENSG00000090097. [P57723-2]
GeneIDi57060.
KEGGihsa:57060.
UCSCiuc003dcf.3. human. [P57723-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176330 mRNA. Translation: AAG09241.1.
AK023993 mRNA. Translation: BAB14761.1.
BC003008 mRNA. Translation: AAH03008.1.
BC004153 mRNA. Translation: AAH04153.1.
BC017098 mRNA. Translation: AAH17098.1.
CCDSiCCDS2839.1. [P57723-1]
CCDS2840.2. [P57723-2]
RefSeqiNP_001167571.1. NM_001174100.1. [P57723-1]
NP_065151.2. NM_020418.3. [P57723-2]
NP_127501.1. NM_033008.2. [P57723-1]
NP_127503.1. NM_033010.2. [P57723-1]
XP_005265388.1. XM_005265331.2. [P57723-1]
XP_006713331.1. XM_006713268.2. [P57723-1]
XP_006713332.1. XM_006713269.1. [P57723-1]
XP_006713333.1. XM_006713270.1. [P57723-2]
UniGeneiHs.20930.

3D structure databases

ProteinModelPortaliP57723.
SMRiP57723. Positions 15-173, 240-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121351. 10 interactions.
IntActiP57723. 4 interactions.
MINTiMINT-2873350.
STRINGi9606.ENSP00000322341.

PTM databases

iPTMnetiP57723.
PhosphoSiteiP57723.

Polymorphism and mutation databases

BioMutaiPCBP4.
DMDMi12230429.

Proteomic databases

EPDiP57723.
MaxQBiP57723.
PaxDbiP57723.
PeptideAtlasiP57723.
PRIDEiP57723.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322099; ENSP00000322341; ENSG00000090097. [P57723-1]
ENST00000355852; ENSP00000348111; ENSG00000090097. [P57723-1]
ENST00000428823; ENSP00000395030; ENSG00000090097. [P57723-2]
ENST00000461554; ENSP00000417196; ENSG00000090097. [P57723-1]
ENST00000484633; ENSP00000417100; ENSG00000090097. [P57723-2]
GeneIDi57060.
KEGGihsa:57060.
UCSCiuc003dcf.3. human. [P57723-1]

Organism-specific databases

CTDi57060.
GeneCardsiPCBP4.
HGNCiHGNC:8652. PCBP4.
MIMi608503. gene.
neXtProtiNX_P57723.
PharmGKBiPA32991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2190. Eukaryota.
ENOG410XNN8. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000182823.
HOVERGENiHBG053520.
InParanoidiP57723.
KOiK13162.
OMAiQYGHPEH.
OrthoDBiEOG7P02J4.
PhylomeDBiP57723.
TreeFamiTF318292.

Enzyme and pathway databases

ReactomeiR-HSA-6804116. TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
R-HSA-69895. Transcriptional activation of cell cycle inhibitor p21.
SignaLinkiP57723.

Miscellaneous databases

ChiTaRSiPCBP4. human.
GeneWikiiPCBP4.
GenomeRNAii57060.
PROiP57723.
SOURCEiSearch...

Gene expression databases

BgeeiP57723.
CleanExiHS_PCBP4.
ExpressionAtlasiP57723. baseline and differential.
GenevisibleiP57723. HS.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR033088. PCBP4.
[Graphical view]
PANTHERiPTHR10288:SF166. PTHR10288:SF166. 1 hit.
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins."
    Makeyev A.V., Liebhaber S.A.
    Genomics 67:301-316(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Lung.
  4. "A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins."
    Chkheidze A.N., Liebhaber S.A.
    Mol. Cell. Biol. 23:8405-8415(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPCBP4_HUMAN
AccessioniPrimary (citable) accession number: P57723
Secondary accession number(s): Q96AH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: July 6, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.