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Protein

Poly(rC)-binding protein 3

Gene

PCBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(rC)-binding protein 3
Alternative name(s):
Alpha-CP3
Gene namesi
Name:PCBP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:8651. PCBP3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32990.

Polymorphism and mutation databases

BioMutaiPCBP3.
DMDMi296439262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Poly(rC)-binding protein 3PRO_0000050092Add
BLAST

Proteomic databases

EPDiP57721.
MaxQBiP57721.
PaxDbiP57721.
PRIDEiP57721.

PTM databases

iPTMnetiP57721.
PhosphoSiteiP57721.

Expressioni

Gene expression databases

BgeeiP57721.
CleanExiHS_PCBP3.
ExpressionAtlasiP57721. baseline and differential.
GenevisibleiP57721. HS.

Organism-specific databases

HPAiHPA030247.

Interactioni

Protein-protein interaction databases

BioGridi119851. 31 interactions.
IntActiP57721. 8 interactions.
MINTiMINT-2862183.
STRINGi9606.ENSP00000383168.

Structurei

3D structure databases

ProteinModelPortaliP57721.
SMRiP57721. Positions 43-231, 258-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 9551KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini129 – 18254KH 2PROSITE-ProRule annotationAdd
BLAST
Domaini293 – 35765KH 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2190. Eukaryota.
ENOG410XNN8. LUCA.
GeneTreeiENSGT00760000119144.
HOVERGENiHBG053520.
InParanoidiP57721.
KOiK13162.
OMAiEDSHNAD.
OrthoDBiEOG7P02J4.
PhylomeDBiP57721.
TreeFamiTF318292.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P57721-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEGDAFWAP SVLPHSTLST LSHHPQPQFG RRMESKVSEG GLNVTLTIRL
60 70 80 90 100
LMHGKEVGSI IGKKGETVKK MREESGARIN ISEGNCPERI VTITGPTDAI
110 120 130 140 150
FKAFAMIAYK FEEDIINSMS NSPATSKPPV TLRLVVPASQ CGSLIGKGGS
160 170 180 190 200
KIKEIRESTG AQVQVAGDML PNSTERAVTI SGTPDAIIQC VKQICVVMLE
210 220 230 240 250
SPPKGATIPY RPKPASTPVI FAGGQAYTIQ GQYAIPHPDQ LTKLHQLAMQ
260 270 280 290 300
QTPFPPLGQT NPAFPGEKLP LHSSEEAQNL MGQSSGLDAS PPASTHELTI
310 320 330 340 350
PNDLIGCIIG RQGTKINEIR QMSGAQIKIA NATEGSSERQ ITITGTPANI
360 370
SLAQYLINAR LTSEVTGMGT L
Note: No experimental confirmation available.
Length:371
Mass (Da):39,465
Last modified:May 18, 2010 - v2
Checksum:i72BADA99CFCBDB1F
GO
Isoform 2 (identifier: P57721-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-225: Missing.
     240-240: Missing.

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):36,817
Checksum:iA92002814D776018
GO
Isoform 3 (identifier: P57721-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-225: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):36,945
Checksum:i3CF1BCEC6B92A550
GO
Isoform 4 (identifier: P57721-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-240: Missing.

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):39,337
Checksum:iB246772514092F63
GO
Isoform 5 (identifier: P57721-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     267-286: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):37,341
Checksum:iA5DB11A821B93B86
GO

Sequence cautioni

The sequence AAG09240.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH12061.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04327.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei201 – 22525Missing in isoform 2 and isoform 3. 1 PublicationVSP_009947Add
BLAST
Alternative sequencei240 – 2401Missing in isoform 2 and isoform 4. 1 PublicationVSP_009948
Alternative sequencei267 – 28620Missing in isoform 5. 1 PublicationVSP_010014Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176329 mRNA. Translation: AAG09240.1. Different initiation.
AK094301 mRNA. Translation: BAC04327.2. Different initiation.
AJ011931 Genomic DNA. No translation available.
AJ239328 Genomic DNA. No translation available.
AL133492 Genomic DNA. No translation available.
AL133493 Genomic DNA. No translation available.
AL592528 Genomic DNA. No translation available.
BC012061 mRNA. Translation: AAH12061.1. Different initiation.
CCDSiCCDS42974.2. [P57721-1]
CCDS46652.1. [P57721-2]
RefSeqiNP_001123613.1. NM_001130141.1. [P57721-2]
NP_065389.2. NM_020528.2. [P57721-1]
UniGeneiHs.474049.

Genome annotation databases

EnsembliENST00000400308; ENSP00000383163; ENSG00000183570. [P57721-2]
ENST00000400309; ENSP00000383164; ENSG00000183570. [P57721-4]
ENST00000400310; ENSP00000383165; ENSG00000183570. [P57721-5]
ENST00000400314; ENSP00000383168; ENSG00000183570. [P57721-1]
GeneIDi54039.
KEGGihsa:54039.
UCSCiuc002zhp.2. human. [P57721-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176329 mRNA. Translation: AAG09240.1. Different initiation.
AK094301 mRNA. Translation: BAC04327.2. Different initiation.
AJ011931 Genomic DNA. No translation available.
AJ239328 Genomic DNA. No translation available.
AL133492 Genomic DNA. No translation available.
AL133493 Genomic DNA. No translation available.
AL592528 Genomic DNA. No translation available.
BC012061 mRNA. Translation: AAH12061.1. Different initiation.
CCDSiCCDS42974.2. [P57721-1]
CCDS46652.1. [P57721-2]
RefSeqiNP_001123613.1. NM_001130141.1. [P57721-2]
NP_065389.2. NM_020528.2. [P57721-1]
UniGeneiHs.474049.

3D structure databases

ProteinModelPortaliP57721.
SMRiP57721. Positions 43-231, 258-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119851. 31 interactions.
IntActiP57721. 8 interactions.
MINTiMINT-2862183.
STRINGi9606.ENSP00000383168.

PTM databases

iPTMnetiP57721.
PhosphoSiteiP57721.

Polymorphism and mutation databases

BioMutaiPCBP3.
DMDMi296439262.

Proteomic databases

EPDiP57721.
MaxQBiP57721.
PaxDbiP57721.
PRIDEiP57721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400308; ENSP00000383163; ENSG00000183570. [P57721-2]
ENST00000400309; ENSP00000383164; ENSG00000183570. [P57721-4]
ENST00000400310; ENSP00000383165; ENSG00000183570. [P57721-5]
ENST00000400314; ENSP00000383168; ENSG00000183570. [P57721-1]
GeneIDi54039.
KEGGihsa:54039.
UCSCiuc002zhp.2. human. [P57721-1]

Organism-specific databases

CTDi54039.
GeneCardsiPCBP3.
HGNCiHGNC:8651. PCBP3.
HPAiHPA030247.
MIMi608502. gene.
neXtProtiNX_P57721.
PharmGKBiPA32990.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2190. Eukaryota.
ENOG410XNN8. LUCA.
GeneTreeiENSGT00760000119144.
HOVERGENiHBG053520.
InParanoidiP57721.
KOiK13162.
OMAiEDSHNAD.
OrthoDBiEOG7P02J4.
PhylomeDBiP57721.
TreeFamiTF318292.

Miscellaneous databases

ChiTaRSiPCBP3. human.
GeneWikiiPCBP3.
GenomeRNAii54039.
NextBioi56330.
PROiP57721.
SOURCEiSearch...

Gene expression databases

BgeeiP57721.
CleanExiHS_PCBP3.
ExpressionAtlasiP57721. baseline and differential.
GenevisibleiP57721. HS.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins."
    Makeyev A.V., Liebhaber S.A.
    Genomics 67:301-316(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Cerebellum.
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  5. "A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins."
    Chkheidze A.N., Liebhaber S.A.
    Mol. Cell. Biol. 23:8405-8415(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPCBP3_HUMAN
AccessioniPrimary (citable) accession number: P57721
Secondary accession number(s): A8MPS2
, A8MQ26, B7WNN9, B7WPC1, Q8N9K6, Q96EP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.