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Protein

Estrogen receptor

Gene

esr1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi152 – 217Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri152 – 172NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri188 – 212NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • estrogen receptor activity Source: ZFIN
  • RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding Source: ZFIN
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone binding Source: ZFIN
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to estrogen stimulus Source: ZFIN
  • posterior lateral line neuromast primordium migration Source: ZFIN
  • response to estradiol Source: ZFIN
  • response to estrogen Source: ZFIN
  • response to xenobiotic stimulus Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:esr1
Synonyms:esr, nr3a1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-020806-5. esr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536281 – 569Estrogen receptorAdd BLAST569

Proteomic databases

PaxDbiP57717.

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024987.

Structurei

3D structure databases

ProteinModelPortaliP57717.
SMRiP57717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 151ModulatingBy similarityAdd BLAST151
Regioni218 – 278HingeAdd BLAST61
Regioni279 – 569Steroid-bindingBy similarityAdd BLAST291

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi284 – 288Poly-Leu5
Compositional biasi475 – 479Poly-Leu5

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 172NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri188 – 212NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000233468.
HOVERGENiHBG108344.
InParanoidiP57717.
KOiK08550.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPKEEHSAG GISSSVNYLD GAYEYPNPTQ TFGTSSPAEP ASVGYYPAPP
60 70 80 90 100
DPHEEHLQTL GGGSSSPLMF APSSPQLSPY LSHHGGHHTT PHQVSYYLDS
110 120 130 140 150
SSSTVYRSSV VSSQQAAVGL CEELCSATDR QELYTGSRAA GGFDSGKETR
160 170 180 190 200
FCAVCSDYAS GYHYGVWSCE GCKAFFKRSI QGHNDYVCPA TNQCTIDRNR
210 220 230 240 250
RKSCQACRLR KCYEVGMMKG GIRKDRGGRS VRRERRRSSN EDRDKSSSDQ
260 270 280 290 300
CSRAGVRTTG PQDKRKKRSG GVVSTLCMSP DQVLLLLLGA EPPAVCSRQK
310 320 330 340 350
HSRPYTEITM MSLLTNMADK ELVHMIAWAK KVPGFQDLSL HDQVQLLESS
360 370 380 390 400
WLEVLMIGLI WRSIHSPGKL IFAQDLILDR SEGECVEGMA EIFDMLLATV
410 420 430 440 450
ARFRSLKLKL EEFVCLKAII LINSGAFSFC SSPVEPLMDN FMVQCMLDNI
460 470 480 490 500
TDALIYCISK SGASLQLQSR RQAQLLLLLS HIRHMSNKGM EHLYRMKCKN
510 520 530 540 550
RVPLYDLLLE MLDAQRFQSS GKVQRVWSQS EKNPPSTPTT SSSSSNNSPR
560
GGAAAIQSNG ACHSHSPDP
Length:569
Mass (Da):62,846
Last modified:April 4, 2003 - v2
Checksum:iCFA0C1AD4376A53C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31T → A in BAB16893 (Ref. 1) Curated1
Sequence conflicti279S → P in BAB16893 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037185 mRNA. Translation: BAB16893.1.
AF349412 mRNA. Translation: AAK16740.1.
RefSeqiNP_694491.1. NM_152959.1.
UniGeneiDr.79999.

Genome annotation databases

GeneIDi259252.
KEGGidre:259252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037185 mRNA. Translation: BAB16893.1.
AF349412 mRNA. Translation: AAK16740.1.
RefSeqiNP_694491.1. NM_152959.1.
UniGeneiDr.79999.

3D structure databases

ProteinModelPortaliP57717.
SMRiP57717.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024987.

Proteomic databases

PaxDbiP57717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi259252.
KEGGidre:259252.

Organism-specific databases

CTDi2099.
ZFINiZDB-GENE-020806-5. esr1.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000233468.
HOVERGENiHBG108344.
InParanoidiP57717.
KOiK08550.

Miscellaneous databases

PROiP57717.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESR1_DANRE
AccessioniPrimary (citable) accession number: P57717
Secondary accession number(s): Q98SM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 4, 2003
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.