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Protein

Calcium-transporting ATPase type 2C member 1

Gene

ATP2C1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi337 – 3371Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi338 – 3381Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi340 – 3401Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi342 – 3421Calcium 2By similarity
Active sitei384 – 38414-aspartylphosphate intermediateBy similarity
Metal bindingi678 – 6781MagnesiumBy similarity
Metal bindingi682 – 6821MagnesiumBy similarity
Metal bindingi772 – 7721Calcium 2By similarity
Metal bindingi776 – 7761Calcium 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 1 (EC:3.6.3.8)
Short name:
ATPase 2C1
Alternative name(s):
Secretory pathway Ca(2+)-transporting ATPase
Gene namesi
Name:ATP2C1
Synonyms:SPCA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 104104CytoplasmicBy similarityAdd
BLAST
Transmembranei105 – 12521Helical; Name=1By similarityAdd
BLAST
Topological domaini126 – 13813LumenalBy similarityAdd
BLAST
Transmembranei139 – 15719Helical; Name=2By similarityAdd
BLAST
Topological domaini158 – 296139CytoplasmicBy similarityAdd
BLAST
Transmembranei297 – 31620Helical; Name=3By similarityAdd
BLAST
Topological domaini317 – 32812LumenalBy similarityAdd
BLAST
Transmembranei329 – 34618Helical; Name=4By similarityAdd
BLAST
Topological domaini347 – 733387CytoplasmicBy similarityAdd
BLAST
Transmembranei734 – 75320Helical; Name=5By similarityAdd
BLAST
Topological domaini754 – 76310LumenalBy similarity
Transmembranei764 – 78421Helical; Name=6By similarityAdd
BLAST
Topological domaini785 – 80420CytoplasmicBy similarityAdd
BLAST
Transmembranei805 – 82420Helical; Name=7By similarityAdd
BLAST
Topological domaini825 – 84218LumenalBy similarityAdd
BLAST
Transmembranei843 – 86220Helical; Name=8By similarityAdd
BLAST
Topological domaini863 – 87513CytoplasmicBy similarityAdd
BLAST
Transmembranei876 – 89419Helical; Name=9By similarityAdd
BLAST
Topological domaini895 – 90915LumenalBy similarityAdd
BLAST
Transmembranei910 – 93021Helical; Name=10By similarityAdd
BLAST
Topological domaini931 – 95323CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 953953Calcium-transporting ATPase type 2C member 1PRO_0000046222Add
BLAST

Proteomic databases

PaxDbiP57709.
PRIDEiP57709.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011626.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015441.

Structurei

3D structure databases

ProteinModelPortaliP57709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00840000129745.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
InParanoidiP57709.
KOiK01537.
OMAiHRTQQDK.
OrthoDBiEOG091G0NXU.
TreeFamiTF354251.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030336. ATP2C1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF214. PTHR24093:SF214. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLLPQSRF SYFKKYPIHA IRKYLSMLRN QKEEEQVARF QKIPNAENET
60 70 80 90 100
MIPVLTSKKA SELPVSEVAS ILQADLQNGL NKCEVSHRRA FHGWNEFDIS
110 120 130 140 150
EDEPLWKKYI SQFKNPLIML LLASAVISVL MHQFDDAVSI TVAILIVVTV
160 170 180 190 200
AFVQEYRSEK SLEELSKLMP PECHCVREGK LEHTLARDLV PGDTVCLSVG
210 220 230 240 250
DRVPADLRLF EAVDLSVDES SLTGETTPCS KVTAPQPAAT NGDLASRSNI
260 270 280 290 300
AFMGTLVRCG KAKGIVIGTG ENSEFGEVFK MMQAEEAPKT PLQKSMDLLG
310 320 330 340 350
KQLSFYSFGI IGIIMLVGWL LGKDILEMFT ISVSLAVAAI PEGLPIVVTV
360 370 380 390 400
TLALGVMRMV KKRAIVKKLP IVETLGCCNV ICSDKTGTLT KNEMTVTHIF
410 420 430 440 450
TSDGLRAEVT GVGYNPFGEV IVDGDVVHGF YNPSVSRIVE AGCVCNDAVI
460 470 480 490 500
RNNTLMGKPT EGALIALAMK MGLDGLQQDY IRKAEYPFSS EQKWMAVKCV
510 520 530 540 550
HRTQQDRPEI CFMKGAYEQV IKYCTTYHSK GQTLTLTQQQ RDLYQQEKAQ
560 570 580 590 600
MGSAGLRVLA LASGPELGQL TFLGLVGIID PPRTGVKEAV TTLIASGVSI
610 620 630 640 650
KMITGDSQET AVAIASRLGL YSKTSQSVSG EEIDAMDVQQ LSQIVPKVAV
660 670 680 690 700
FYRASPRHKM KIIKSLQKNG SVVAMTGDGV NDAVALKAAD IGVAMGQTGT
710 720 730 740 750
DVCKEAADMI LVDDDFQTIM SAIEEGKGIY NNIKNFVRFQ LSTSIAALTL
760 770 780 790 800
ISLATLMNFP NPLNAMQILW INIIMDGPPA QSLGVEPVDK DVIRKPPRNW
810 820 830 840 850
KDSILTKNLI LKILVSSIII VCGTLFVFWR ELRDNVITPR DTTMTFTCFV
860 870 880 890 900
FFDMFNALSS RSQTKSVFEI GLCSNKMFCY AVLGSIMGQL LVIYFPPLQK
910 920 930 940 950
VFQTESLSIL DLLFLLGLTS SVCIVAEIIK KVERSREKIQ KPVSSTSSSF

LEV
Length:953
Mass (Da):104,780
Last modified:January 11, 2001 - v1
Checksum:i2412EEB45AFB000F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230532 mRNA. Translation: AAF64433.1.
RefSeqiNP_786979.1. NM_175785.2.
UniGeneiBt.269.

Genome annotation databases

EnsembliENSBTAT00000015441; ENSBTAP00000015441; ENSBTAG00000011626.
GeneIDi327663.
KEGGibta:327663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230532 mRNA. Translation: AAF64433.1.
RefSeqiNP_786979.1. NM_175785.2.
UniGeneiBt.269.

3D structure databases

ProteinModelPortaliP57709.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015441.

Proteomic databases

PaxDbiP57709.
PRIDEiP57709.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015441; ENSBTAP00000015441; ENSBTAG00000011626.
GeneIDi327663.
KEGGibta:327663.

Organism-specific databases

CTDi27032.

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00840000129745.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
InParanoidiP57709.
KOiK01537.
OMAiHRTQQDK.
OrthoDBiEOG091G0NXU.
TreeFamiTF354251.

Enzyme and pathway databases

ReactomeiR-BTA-936837. Ion transport by P-type ATPases.

Gene expression databases

BgeeiENSBTAG00000011626.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030336. ATP2C1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF214. PTHR24093:SF214. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT2C1_BOVIN
AccessioniPrimary (citable) accession number: P57709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.