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Protein

Potassium-transporting ATPase ATP-binding subunit

Gene

kdpB

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + K+(Out) = ADP + phosphate + K+(In).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2954-aspartylphosphate intermediateUniRule annotation1
Binding sitei332ATPUniRule annotation1
Binding sitei336ATPUniRule annotation1
Binding sitei382ATPUniRule annotation1
Metal bindingi501MagnesiumUniRule annotation1
Metal bindingi505MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi364 – 371ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BRENDAi3.6.3.12. 6324.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase ATP-binding subunitUniRule annotation (EC:3.6.3.12UniRule annotation)
Alternative name(s):
ATP phosphohydrolase [potassium-transporting] B chainUniRule annotation
Potassium-binding and translocating subunit BUniRule annotation
Potassium-translocating ATPase B chainUniRule annotation
Gene namesi
Name:kdpBUniRule annotation
Ordered Locus Names:Ta1309
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei56 – 76HelicalUniRule annotationAdd BLAST21
Transmembranei207 – 227HelicalUniRule annotationAdd BLAST21
Transmembranei244 – 264HelicalUniRule annotationAdd BLAST21
Transmembranei570 – 590HelicalUniRule annotationAdd BLAST21
Transmembranei596 – 616HelicalUniRule annotationAdd BLAST21
Transmembranei644 – 664HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461521 – 665Potassium-transporting ATPase ATP-binding subunitAdd BLAST665

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP57700.

Interactioni

Subunit structurei

The system is composed of three essential subunits: KdpA, KdpB and KdpC.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta1309.

Structurei

3D structure databases

ProteinModelPortaliP57700.
SMRiP57700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG01577. Archaea.
COG2216. LUCA.
HOGENOMiHOG000244113.
KOiK01547.
OMAiILWLWFT.
OrthoDBiPOG093Z00WB.

Family and domain databases

CDDicd02078. P-type_ATPase_K. 1 hit.
Gene3Di3.40.1110.10. 1 hit.
HAMAPiMF_00285. KdpB. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006391. P-type_ATPase_bsu_IA.
IPR001757. P_typ_ATPase.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01497. kdpB. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

P57700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFMKVYEEF LLTLKNMRPD VIIHNPVMFL TEMSLFLSVF IYAFPGFFGV
60 70 80 90 100
PSSTTYLQFY LAVVILLFLT VFFSSMSTAM SEGKSKAITD SLKKFKTEVT
110 120 130 140 150
AHVIRDGNPV DVKSTDLRKG DIIVVYRDEI IPIDGEVIEG SGYVDESNVT
160 170 180 190 200
GESRAVMKVI GDTVTGSTRL VTDKIKIRAT ADPGSTFIDK MIDLVNRATR
210 220 230 240 250
EKTPNEIALT VFLSGLTLIF LIITASIFSI SHYYGRTANV MMLIVLLIAL
260 270 280 290 300
IPTTIGALLP AIGIAAINKV SEYNIIAKSG RAIENAGDID TIILDKTGTI
310 320 330 340 350
TIGERQAVRM YPNKGVDDKE FYRMCALASF YDQTKEGISI LNLARSNGIT
360 370 380 390 400
VSEEDLRGYS FIPFSSETKY SGLESDSDYI IKGSLHALKE KFHVADEFIE
410 420 430 440 450
ALCKEISMRG GTAIPVVHNG KFAGVIELQD LIKPGIKERI AEIKNMDIKT
460 470 480 490 500
VMCTGDDEVT AQYISAQVGL DEYIANSKPI DKYNVVIREK ERQRMVAMVG
510 520 530 540 550
DGTNDAPALA KADVGLAMNN GTQAAKEAAN MIDLDSNPTK LMDVIFLGKQ
560 570 580 590 600
ILITRGALTT FSIANDISKY FVIIPAIFYM FPSLSMVNVL DLTDPIVAVT
610 620 630 640 650
SALIFNTIII VFLIPLALGG VKYKPTSISD LLKRNIMIYG LGGVVVPFIA
660
IKLIYMLLVA LGVVW
Length:665
Mass (Da):73,016
Last modified:December 8, 2000 - v1
Checksum:i96C72CFA612435EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445067 Genomic DNA. Translation: CAC12430.1.

Genome annotation databases

EnsemblBacteriaiCAC12430; CAC12430; CAC12430.
KEGGitac:Ta1309.

Similar proteinsi

Entry informationi

Entry nameiKDPB_THEAC
AccessioniPrimary (citable) accession number: P57700
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: December 8, 2000
Last modified: August 30, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families