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Protein

Proteasome subunit alpha

Gene

psmA

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PsmAUniRule annotation
Gene namesi
Name:psmAUniRule annotation
Ordered Locus Names:VNG_0166G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241701 – 253Proteasome subunit alphaAdd BLAST253

Proteomic databases

PaxDbiP57697
PRIDEiP57697

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG0166G

Structurei

3D structure databases

ProteinModelPortaliP57697
SMRiP57697
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00971 Archaea
COG0638 LUCA
InParanoidiP57697
KOiK03432
OMAiFQVEYAR
OrthoDBiPOG093Z086S
PhylomeDBiP57697

Family and domain databases

CDDicd03756 proteasome_alpha_archeal, 1 hit
Gene3Di3.60.20.101 hit
HAMAPiMF_00289_A Proteasome_A_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR019982 Proteasome_asu_arc
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03633 arc_protsome_A, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P57697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGQNQQQAY DRGITIFSPD GRLYQVEYAR EAVKRGTASI GVRTPEGVVL
60 70 80 90 100
VVDKQTRSPL LEGSSVEKLH KIDDHVGAAS AGHVADARQL VDFARQQSQV
110 120 130 140 150
ERVRYDEPIG VRTLTKSVTD HIQQYTQVGG ARPFGVALLI AGVEGGEPRL
160 170 180 190 200
FETDPSGTSN EWKAVAIGSN RGDIQEFLED EYDAGLSVDD GIDLALRALN
210 220 230 240 250
EGREDALSGD GVGVGIVDAD TGTYRELAAD ESQSYIDDIE DAADDSDDDD

DEE
Length:253
Mass (Da):27,343
Last modified:December 8, 2000 - v1
Checksum:i6EFADB7FF247E273
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG18783.1
PIRiC84177
RefSeqiWP_010902078.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG18783; AAG18783; VNG_0166G
GeneIDi5953913
KEGGihal:VNG_0166G
PATRICifig|64091.14.peg.119

Similar proteinsi

Entry informationi

Entry nameiPSA_HALSA
AccessioniPrimary (citable) accession number: P57697
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: December 8, 2000
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome