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P57696

- DHPS_NEIMC

UniProt

P57696 - DHPS_NEIMC

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Protein

Dihydropteroate synthase

Gene
folP, dhpS
Organism
Neisseria meningitidis serogroup C
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi25 – 251Magnesium By similarity
Binding sitei33 – 331Substrate By similarity
Binding sitei99 – 991Substrate By similarity
Binding sitei119 – 1191Substrate By similarity
Binding sitei190 – 1901Substrate By similarity
Binding sitei227 – 2271Substrate By similarity
Binding sitei262 – 2621Substrate By similarity
Binding sitei264 – 2641Substrate By similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
Synonyms:dhpS
OrganismiNeisseria meningitidis serogroup C
Taxonomic identifieri135720 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Dihydropteroate synthasePRO_0000168219Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP57696.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 274257Pterin-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 672Substrate binding By similarity

Sequence similaritiesi

Belongs to the DHPS family.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57696-1 [UniParc]FASTAAdd to Basket

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MARHVWQAGR FEIGLDKPKI MGIVNLTPDS FSDGGVYSQN AQTALAHAEQ    50
LLKEGADILD IGGESTRSGA DYVSPEEEWA RVEPVLAEVA GWGVPISLDT 100
RRTVIMEKAL ALGGIDIIND VAALNDEGAV ELLARQADTG ICLMHMQGLP 150
KNMQINPKYQ DVVGEVARYL KARAAECIAA GIAPQRITLD PGFCFGKTLQ 200
HNITLMRHLP ELMAETGYPL LIGVSRKSMI GELTGETDAA ARGHGSVAAA 250
LAAVARGAKI VRVHDVKATA DALKAWEALG INL 283
Length:283
Mass (Da):30,167
Last modified:September 26, 2001 - v2
Checksum:iFE8D19EFA15FA034
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361V → A in strain: BT054.
Natural varianti42 – 432QT → RI in strain: BT054.
Natural varianti50 – 501Q → R in strain: BT054.
Natural varianti68 – 681S → P in strain: BT054.
Natural varianti96 – 961I → V in strain: BT054.
Natural varianti104 – 1052VI → AV in strain: BT054.
Natural varianti107 – 1071E → G in strain: BT054.
Natural varianti125 – 1251N → T in strain: BT054.
Natural varianti137 – 1371A → T in strain: BT054.
Natural varianti151 – 1511K → E in strain: BT054.
Natural varianti152 – 1521N → T in strain: MO124.
Natural varianti174 – 1741A → S in strain: MO124.
Natural varianti178 – 1781I → V in strain: BT054.
Natural varianti188 – 1881T → I in strain: MO124.
Natural varianti194 – 1941C → G in strain: BT054.
Natural varianti194 – 1941C → GSG in strain: MO124.
Natural varianti198 – 1981T → P in strain: MO124.
Natural varianti204 – 2041T → A in strain: BT054 and MO124.
Natural varianti218 – 2181Y → F in strain: BT054 and MO124.
Natural varianti228 – 2281S → R in strain: BT054.
Natural varianti229 – 2291M → T in strain: MO124.
Natural varianti230 – 2301I → V in strain: BT054.
Natural varianti237 – 2382TD → AN in strain: MO124.
Natural varianti241 – 2411A → E in strain: MO124.
Natural varianti243 – 2431G → V in strain: BT054 and MO124.
Natural varianti253 – 2531A → S in strain: BT054 and MO124.
Natural varianti259 – 2591K → Q in strain: BT054 and MO124.
Natural varianti275 – 2751A → V in strain: BT054 and MO124.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68063 Genomic DNA. Translation: CAA48200.1.
X68067 Genomic DNA. Translation: CAA48204.1.
X68064 Genomic DNA. Translation: CAA48201.1.
PIRiA57423.
S25612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68063 Genomic DNA. Translation: CAA48200.1 .
X68067 Genomic DNA. Translation: CAA48204.1 .
X68064 Genomic DNA. Translation: CAA48201.1 .
PIRi A57423.
S25612.

3D structure databases

ProteinModelPortali P57696.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transformational exchanges in the dihydropteroate synthase gene of Neisseria meningitidis: a novel mechanism for acquisition of sulfonamide resistance."
    Raadstroem P., Fermer C., Kristiansen B.-E., Jenkins A., Skoeld O., Swedberg G.
    J. Bacteriol. 174:6386-6393(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BT054 / Serogroup C / Serotype 15, BT227 / Serogroup C / Serotype 2a and CCUG 23102 / MO124 / Serogroup C / Serotype 15.

Entry informationi

Entry nameiDHPS_NEIMC
AccessioniPrimary (citable) accession number: P57696
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: September 26, 2001
Last modified: February 19, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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