P57634 (MTLD_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	BU571

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170699
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57634 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: C8B2D91910E97E2F	FASTA	385	43,825
	10 20 30 40 50 60 MKALQFGAGN IGRGFIGKTL SESGFSVIFS DVNQNIVDAI NYNREYFVKI IGSNQNKTVN 70 80 90 100 110 120 IKRVSAINSN DSNIKKIISS VDLITTAVGP TALEKIALII TQGIIFKIKN QFTKPLNIIA 130 140 150 160 170 180 CENKIKSSSF LKQVVLKNLP IKYHDYLNKY IGFIDCSIDT IIPAINNKDD LFLTVEEFKE 190 200 210 220 230 240 WIVNINQFKG AVPKIVDMKF SNNLDAFIER KLFTLNTGHA IAAYLGLIKN YKTIQDAISD 250 260 270 280 290 300 KKIRVIVRSA MEESGSVLIK RYNFNKNDHL DYIEKIFLRF ENPFLSDKLE RIGRNPLQKL 310 320 330 340 350 360 RREDRLIKPF LGAFEYNLPY SNLAKGIAAA FYYHNKNDLE SIELSSSIKK QGLESTIIKI 370 380 CDLPVNSKEV YSIILEYNLI KKIIR

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB13261.1.
RefSeq	NP_240375.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57634.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000002776; EBBUCP00000002552; EBBUCG00000002776.
GeneID	1109911.
GenomeReviews	Gene locus BU571 in contig BA000003_GR.
KEGG	buc:BU571.
PATRIC	21244686. VBIBucAph127364_0574.
Phylogenomic databases
GeneTree	EBGT00050000007918.
HOGENOM	HBG568825.
OMA	WIVNINQ.
PhylomeDB	P57634.
ProtClustDB	PRK02318.
Enzyme and pathway databases
BioCyc	BSP107806:BU571-MONOMER.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_BUCAI

Accession

Primary (citable) accession number: P57634

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program