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P57604

- AROB_BUCAI

UniProt

P57604 - AROB_BUCAI

Protein

3-dehydroquinate synthase

Gene

aroB

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.

    Cofactori

    NAD.By similarity
    Divalent metal cations.By similarity

    Pathwayi

    GO - Molecular functioni

    1. 3-dehydroquinate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-538-MONOMER.
    UniPathwayiUPA00053; UER00085.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-dehydroquinate synthase (EC:4.2.3.4)
    Gene namesi
    Name:aroB
    Ordered Locus Names:BU538
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3633633-dehydroquinate synthasePRO_0000140717Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP57604.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dehydroquinate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0337.
    HOGENOMiHOG000007970.
    KOiK01735.
    OMAiWLEQHID.
    OrthoDBiEOG6SJJGD.

    Family and domain databases

    HAMAPiMF_00110. DHQ_synthase.
    InterProiIPR016037. DHQ_synth_AroB.
    [Graphical view]
    PIRSFiPIRSF001455. DHQ_synth. 1 hit.
    TIGRFAMsiTIGR01357. aroB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P57604-1 [UniParc]FASTAAdd to Basket

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    MKIVERLQVV LGERSYPISI GAGIIQEDDI FWPLKPGDQA MLVTNKTLAN    50
    LLKDKVFYHL RKSGIKIDQV ILSDGEQYKT LNEMELIISA LLEKKHARDT 100
    TLIALGGGVI GDLAGFAASV YQRGVRFIQI PTTLLSQVDA SVGGKTAVNH 150
    LLGKNMIGSF WQPSSVIIDI DCLKTLPYNE LVSGMAEVIK YAIVFDKTFF 200
    CWLEENIESI LSLNHTAMSY CIKKCCELKS QLIALDEREN NLRALLNLGH 250
    TYGHAIEVHA GYGNWLHGEA ISVGMVMAAR TSELLGHLKT IDFKRILVLL 300
    KRTGLPIKGP KNMSAASYLP YMMRDKKVIS GEMRLVLPLS IGKAEIYSNI 350
    DKNIILTAIK HSQ 363
    Length:363
    Mass (Da):40,297
    Last modified:December 1, 2000 - v1
    Checksum:i1DB8EC7B8D8F6EC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13231.1.
    RefSeqiNP_240345.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13231; BAB13231; BAB13231.
    GeneIDi1109881.
    KEGGibuc:BU538.
    PATRICi21244618. VBIBucAph127364_0543.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13231.1 .
    RefSeqi NP_240345.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57604.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13231 ; BAB13231 ; BAB13231 .
    GeneIDi 1109881.
    KEGGi buc:BU538.
    PATRICi 21244618. VBIBucAph127364_0543.

    Phylogenomic databases

    eggNOGi COG0337.
    HOGENOMi HOG000007970.
    KOi K01735.
    OMAi WLEQHID.
    OrthoDBi EOG6SJJGD.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00085 .
    BioCyci BAPH107806:GBZJ-538-MONOMER.

    Family and domain databases

    HAMAPi MF_00110. DHQ_synthase.
    InterProi IPR016037. DHQ_synth_AroB.
    [Graphical view ]
    PIRSFi PIRSF001455. DHQ_synth. 1 hit.
    TIGRFAMsi TIGR01357. aroB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiAROB_BUCAI
    AccessioniPrimary (citable) accession number: P57604
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3