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P57604 (AROB_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:BU538
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera ›

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP-Rule MF_00110

Cofactor

NAD By similarity. HAMAP-Rule MF_00110

Divalent metal cations By similarity. HAMAP-Rule MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP-Rule MF_00110

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00110

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: HAMAP

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3633633-dehydroquinate synthase HAMAP-Rule MF_00110
PRO_0000140717

Sequences

Sequence LengthMass (Da)Tools
P57604 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 1DB8EC7B8D8F6EC8

FASTA36340,297
        10         20         30         40         50         60 
MKIVERLQVV LGERSYPISI GAGIIQEDDI FWPLKPGDQA MLVTNKTLAN LLKDKVFYHL 

        70         80         90        100        110        120 
RKSGIKIDQV ILSDGEQYKT LNEMELIISA LLEKKHARDT TLIALGGGVI GDLAGFAASV 

       130        140        150        160        170        180 
YQRGVRFIQI PTTLLSQVDA SVGGKTAVNH LLGKNMIGSF WQPSSVIIDI DCLKTLPYNE 

       190        200        210        220        230        240 
LVSGMAEVIK YAIVFDKTFF CWLEENIESI LSLNHTAMSY CIKKCCELKS QLIALDEREN 

       250        260        270        280        290        300 
NLRALLNLGH TYGHAIEVHA GYGNWLHGEA ISVGMVMAAR TSELLGHLKT IDFKRILVLL 

       310        320        330        340        350        360 
KRTGLPIKGP KNMSAASYLP YMMRDKKVIS GEMRLVLPLS IGKAEIYSNI DKNIILTAIK 


HSQ

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000003 Genomic DNA. Translation: BAB13231.1.
RefSeqNP_240345.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57604.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB13231; BAB13231; BAB13231.
GeneID1109881.
KEGGbuc:BU538.
PATRIC21244618. VBIBucAph127364_0543.

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHOG000007970.
KOK01735.
OMAVMALEMS.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-538-MONOMER.
UniPathwayUPA00053; UER00085.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. aroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BUCAI
AccessionPrimary (citable) accession number: P57604
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 29, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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