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P57604

- AROB_BUCAI

UniProt

P57604 - AROB_BUCAI

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Protein

3-dehydroquinate synthase

Gene

aroB

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.

Cofactori

NAD.By similarity
Divalent metal cations.By similarity

Pathwayi

GO - Molecular functioni

  1. 3-dehydroquinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-538-MONOMER.
UniPathwayiUPA00053; UER00085.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate synthase (EC:4.2.3.4)
Gene namesi
Name:aroB
Ordered Locus Names:BU538
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3633633-dehydroquinate synthasePRO_0000140717Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP57604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dehydroquinate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0337.
HOGENOMiHOG000007970.
KOiK01735.
OMAiWLEQHID.
OrthoDBiEOG6SJJGD.

Family and domain databases

HAMAPiMF_00110. DHQ_synthase.
InterProiIPR016037. DHQ_synth_AroB.
[Graphical view]
PIRSFiPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsiTIGR01357. aroB. 1 hit.

Sequencei

Sequence statusi: Complete.

P57604 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIVERLQVV LGERSYPISI GAGIIQEDDI FWPLKPGDQA MLVTNKTLAN
60 70 80 90 100
LLKDKVFYHL RKSGIKIDQV ILSDGEQYKT LNEMELIISA LLEKKHARDT
110 120 130 140 150
TLIALGGGVI GDLAGFAASV YQRGVRFIQI PTTLLSQVDA SVGGKTAVNH
160 170 180 190 200
LLGKNMIGSF WQPSSVIIDI DCLKTLPYNE LVSGMAEVIK YAIVFDKTFF
210 220 230 240 250
CWLEENIESI LSLNHTAMSY CIKKCCELKS QLIALDEREN NLRALLNLGH
260 270 280 290 300
TYGHAIEVHA GYGNWLHGEA ISVGMVMAAR TSELLGHLKT IDFKRILVLL
310 320 330 340 350
KRTGLPIKGP KNMSAASYLP YMMRDKKVIS GEMRLVLPLS IGKAEIYSNI
360
DKNIILTAIK HSQ
Length:363
Mass (Da):40,297
Last modified:December 1, 2000 - v1
Checksum:i1DB8EC7B8D8F6EC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13231.1.
RefSeqiNP_240345.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13231; BAB13231; BAB13231.
GeneIDi1109881.
KEGGibuc:BU538.
PATRICi21244618. VBIBucAph127364_0543.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13231.1 .
RefSeqi NP_240345.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57604.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13231 ; BAB13231 ; BAB13231 .
GeneIDi 1109881.
KEGGi buc:BU538.
PATRICi 21244618. VBIBucAph127364_0543.

Phylogenomic databases

eggNOGi COG0337.
HOGENOMi HOG000007970.
KOi K01735.
OMAi WLEQHID.
OrthoDBi EOG6SJJGD.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00085 .
BioCyci BAPH107806:GBZJ-538-MONOMER.

Family and domain databases

HAMAPi MF_00110. DHQ_synthase.
InterProi IPR016037. DHQ_synth_AroB.
[Graphical view ]
PIRSFi PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsi TIGR01357. aroB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiAROB_BUCAI
AccessioniPrimary (citable) accession number: P57604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3