Reviewed, UniProtKB/Swiss-Prot P57604 (AROB_BUCAI)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BU538

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [Complete proteome] [HAMAP]

Taxonomic identifier

118099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	NAD By similarity. Divalent metal cations By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000140717

Sequences

	Sequence		Length	Mass (Da)
	P57604-1 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 1DB8EC7B8D8F6EC8	FASTA	363	40,297
	10 20 30 40 50 60 MKIVERLQVV LGERSYPISI GAGIIQEDDI FWPLKPGDQA MLVTNKTLAN LLKDKVFYHL 70 80 90 100 110 120 RKSGIKIDQV ILSDGEQYKT LNEMELIISA LLEKKHARDT TLIALGGGVI GDLAGFAASV 130 140 150 160 170 180 YQRGVRFIQI PTTLLSQVDA SVGGKTAVNH LLGKNMIGSF WQPSSVIIDI DCLKTLPYNE 190 200 210 220 230 240 LVSGMAEVIK YAIVFDKTFF CWLEENIESI LSLNHTAMSY CIKKCCELKS QLIALDEREN 250 260 270 280 290 300 NLRALLNLGH TYGHAIEVHA GYGNWLHGEA ISVGMVMAAR TSELLGHLKT IDFKRILVLL 310 320 330 340 350 360 KRTGLPIKGP KNMSAASYLP YMMRDKKVIS GEMRLVLPLS IGKAEIYSNI DKNIILTAIK HSQ

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tokyo 1998.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000003 Genomic DNA. Translation: BAB13231.1.
RefSeq	NP_240345.1.
3D structure databases
HSSP	HSSP built from PDB template 1DQS based on UniProtKB P07547.
ModBase	Search...
Genome annotation databases
GeneID	1109881.
GenomeReviews	Gene locus BU538 in contig BA000003_GR.
KEGG	buc:BU538.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P57604.
OMA	EDYLPHM.
Enzyme and pathway databases
BioCyc	BSP107806:BU538-MON.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BUCAI

Accession

Primary (citable) accession number: P57604

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)