P57599 (FKBA_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
Short name=PPIase
EC=5.2.1.8

Alternative name(s):
Rotamase

Gene names

Name:	fkpA
Ordered Locus Names:	BU533

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Acyrthosiphon pisum)

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	FKBP-type peptidyl-prolyl cis-trans isomerase FkpA		PRO_0000075364
Regions
	Domain	153 – 241	89	PPIase FKBP-type

Sequences

	Sequence		Length	Mass (Da)
	P57599 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 55D5E99740188C3F	FASTA	241	26,946
	10 20 30 40 50 60 MILYVPKSFS ISAPISDIHL QSVLETKNTF HNNNEKLGYI LGLSFGNYVN QTFEKQKKIG 70 80 90 100 110 120 IELDRNSLLK GIQDAISGNL KLSHQDISSG LKELEKKLKH ATKIQLKKNA KENFIQGELY 130 140 150 160 170 180 MKNFSKLKGV KKTSSGLLYL LERAGEGEAL KDETKITVHY KGTLINGLEF DNSYKRGRPV 190 200 210 220 230 240 SLRLKDVILG WKEGLKYIKK GGKIKLVIPP NLAYGTEEVN GIPANSTLIF DIELLDVVNG V

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB13226.1.
RefSeq	NP_240340.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57599.
SMR	P57599. Positions 30-237.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB13226; BAB13226; BAB13226.
GeneID	1109876.
KEGG	buc:BU533.
PATRIC	21244608. VBIBucAph127364_0538.
Phylogenomic databases
eggNOG	COG0545.
HOGENOM	HOG000154888.
KO	K03772.
OMA	ETGKAVH.
ProtClustDB	CLSK390914.
Enzyme and pathway databases
BioCyc	BAPH107806:GBZJ-533-MONOMER.
Family and domain databases
Gene3D	1.10.287.460. 1 hit.
InterPro	IPR023566. PPIase_FKBP. IPR001179. PPIase_FKBP_dom. IPR000774. PPIase_FKBP_N. [Graphical view]
PANTHER	PTHR10516. PTHR10516. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. PF01346. FKBP_N. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FKBA_BUCAI

Accession

Primary (citable) accession number: P57599

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	May 29, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program