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Protein

FKBP-type peptidyl-prolyl cis-trans isomerase FkpA

Gene

fkpA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-533-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Rotamase
Gene namesi
Name:fkpA
Ordered Locus Names:BU533
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241FKBP-type peptidyl-prolyl cis-trans isomerase FkpAPRO_0000075364Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi107806.BU533.

Structurei

3D structure databases

ProteinModelPortaliP57599.
SMRiP57599. Positions 30-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 24189PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154888.
KOiK03772.
OMAiLAYGNEF.
OrthoDBiEOG6DRPKW.

Family and domain databases

Gene3Di1.10.287.460. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR000774. PPIase_FKBP_N.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
PF01346. FKBP_N. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILYVPKSFS ISAPISDIHL QSVLETKNTF HNNNEKLGYI LGLSFGNYVN
60 70 80 90 100
QTFEKQKKIG IELDRNSLLK GIQDAISGNL KLSHQDISSG LKELEKKLKH
110 120 130 140 150
ATKIQLKKNA KENFIQGELY MKNFSKLKGV KKTSSGLLYL LERAGEGEAL
160 170 180 190 200
KDETKITVHY KGTLINGLEF DNSYKRGRPV SLRLKDVILG WKEGLKYIKK
210 220 230 240
GGKIKLVIPP NLAYGTEEVN GIPANSTLIF DIELLDVVNG V
Length:241
Mass (Da):26,946
Last modified:December 1, 2000 - v1
Checksum:i55D5E99740188C3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13226.1.
RefSeqiNP_240340.1. NC_002528.1.
WP_010896151.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13226; BAB13226; BAB13226.
GeneIDi1109876.
KEGGibuc:BU533.
PATRICi21244608. VBIBucAph127364_0538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13226.1.
RefSeqiNP_240340.1. NC_002528.1.
WP_010896151.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57599.
SMRiP57599. Positions 30-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi107806.BU533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB13226; BAB13226; BAB13226.
GeneIDi1109876.
KEGGibuc:BU533.
PATRICi21244608. VBIBucAph127364_0538.

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154888.
KOiK03772.
OMAiLAYGNEF.
OrthoDBiEOG6DRPKW.

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-533-MONOMER.

Family and domain databases

Gene3Di1.10.287.460. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR000774. PPIase_FKBP_N.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
PF01346. FKBP_N. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiFKBA_BUCAI
AccessioniPrimary (citable) accession number: P57599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 22, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.