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Protein

Multidrug resistance-like ATP-binding protein MdlB

Gene

mdlB

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 382ATP8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-like ATP-binding protein MdlB (EC:3.6.3.44)
Gene namesi
Name:mdlB
Ordered Locus Names:BU480
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalAdd BLAST21
Transmembranei61 – 81HelicalAdd BLAST21
Transmembranei150 – 170HelicalAdd BLAST21
Transmembranei173 – 193HelicalAdd BLAST21
Transmembranei247 – 267HelicalAdd BLAST21
Transmembranei268 – 288HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000924991 – 580Multidrug resistance-like ATP-binding protein MdlBAdd BLAST580

Interactioni

Protein-protein interaction databases

STRINGi107806.BU480.

Structurei

3D structure databases

ProteinModelPortaliP57552.
SMRiP57552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 310ABC transmembrane type-1Add BLAST286
Domaini341 – 575ABC transporterAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK18890.
OMAiVFITQRL.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P57552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHLIAFWPI LKRLLIYVKP HKKKLILAFI FLLSGSTSEV LGPILISYFI
60 70 80 90 100
NNILSKHQLH LLIILTIITL FIILQILSVF LNYFQSILFN KIAVESINKL
110 120 130 140 150
RQDVMYAALQ QPISEFDSQP IGQMISKVTN DTEAVKELYD TVGPTLFRSI
160 170 180 190 200
ILIFIILFAM FTLEWHMALV ALFILPLVIT IMLVYQYYST PLLRKVRYYL
210 220 230 240 250
AEINNKFNET INGMNVIQQF CQQRRFQEKI KKSSDLHYMS RMKILRLDGF
260 270 280 290 300
LLRPLLSLLS SMILCNFMFL FSFFPVGAFE VGVLYAFITY LGRLNEPLIA
310 320 330 340 350
ITIQQSVLQQ SIVAGERIFS LIDSPKQKYG KNKDLLKSGK INIQNVSFYH
360 370 380 390 400
KNCNKNILEN INIKISSKSF VAFVGHTGSG KSTLANLIMG YYPLKNGKIY
410 420 430 440 450
LDDKSIDSIS HSVLRRNVLM VQQDPIVLSD TFFYNITLGR KIPEEKVWNI
460 470 480 490 500
LDTVHLSDLV KSMPKGIYSL LGEEGNNLSV GQKQLLAIAR VLVAYPKVLI
510 520 530 540 550
LDEATANIDS GTEQLIQKTL LSIRKNCTLI IIAHRLSTII EADSIIVLKK
560 570 580
GKIVEFGTHE QLLTKKSCYY KMYKFQSCKF
Length:580
Mass (Da):66,403
Last modified:December 1, 2000 - v1
Checksum:iBA2872BA2E76E200
GO

Sequence cautioni

The sequence BAB13177 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13177.1. Different initiation.
RefSeqiNP_240291.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13177; BAB13177; BAB13177.
GeneIDi1109827.
KEGGibuc:BU480.
PATRICifig|107806.10.peg.489.

Similar proteinsi

Entry informationi

Entry nameiMDLB_BUCAI
AccessioniPrimary (citable) accession number: P57552
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 22, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families