P57551 (MDLA_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Multidrug resistance-like ATP-binding protein MdlA
EC=3.6.3.44

Gene names

Name:	mdlA
Ordered Locus Names:	BU479

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	589 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xenobiotic-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 589	589	Multidrug resistance-like ATP-binding protein MdlA		PRO_0000092493
Regions
	Transmembrane	23 – 43	21	Helical; Potential
	Transmembrane	53 – 73	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Transmembrane	155 – 175	21	Helical; Potential
	Transmembrane	247 – 267	21	Helical; Potential
	Transmembrane	280 – 300	21	Helical; Potential
	Domain	18 – 303	286	ABC transmembrane type-1
	Domain	334 – 571	238	ABC transporter
	Nucleotide binding	369 – 376	8	ATP Potential
	Compositional bias	519 – 522	4	Poly-Lys

Sequences

	Sequence		Length	Mass (Da)
	P57551 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: AF736FA2FA60A56A	FASTA	589	67,522
	10 20 30 40 50 60 MKLFNQLRWF FVREWKRYLG AILLLIIIAT LQLLPPKIVG VLIDLIIKKN MHGVQILPWI 70 80 90 100 110 120 LIIFLVAVIV YILRYLWRIL LFGASYQLAT ELRVKFYTYL SQQSQIFFLK NRTGDLIARA 130 140 150 160 170 180 TNDVDRVVFA AGEGVLTLVD SLVMGFSVLI VMSTQISFLL TIISLIPMPI MAILIKKYGK 190 200 210 220 230 240 ELHETFRHAQ ISFSLLNNQT QEILTSIRMI RAFGLEKNQS NKFNIITRNT GKKNMEVAKI 250 260 270 280 290 300 DARFDPVIYL SVAFSNLLAI IGGGWLVWNN QISIGQLTSF IMYLGLMIWP MLALAWMFNI 310 320 330 340 350 360 VERGSAAWDR IHSIINKKLY IEDGKNNIPP YPGILNINIK KFYYPNNQKP SLKDIRILIK 370 380 390 400 410 420 PGNTLGICGP TGSGKSTLLM LIQRQFNFKK EEIHYHSLSL LEIKIDDWRR RIAVVNQTSF 430 440 450 460 470 480 LFSDTISNNI SLGKPNASQK EIEEVAKLAD VHKDIIDLPE RYETQVGERG VMLSGGQKQR 490 500 510 520 530 540 VCIARALLLN AEILILDDAL SAVDAQTENN ILKNINEWKK KKHSLIITTH RLSALINSDE 550 560 570 580 IIVIKSGSII QRGNHLKLIQ EKNWYKSMYY YQQSEIELED NEKTGEKNL

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB13176.1.
RefSeq	NP_240290.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57551.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000003122; EBBUCP00000002898; EBBUCG00000003122.
GeneID	1109826.
GenomeReviews	Gene locus BU479 in contig BA000003_GR.
KEGG	buc:BU479.
PATRIC	21244500. VBIBucAph127364_0488.
Phylogenomic databases
GeneTree	EBGT00050000007760.
HOGENOM	HBG758042.
OMA	ILNINIK.
PhylomeDB	P57551.
ProtClustDB	CLSK316283.
Enzyme and pathway databases
BioCyc	BSP107806:BU479-MONOMER.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K06147.
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDLA_BUCAI

Accession

Primary (citable) accession number: P57551

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program