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Protein

Multidrug resistance-like ATP-binding protein MdlA

Gene

mdlA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi369 – 376ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-like ATP-binding protein MdlA (EC:3.6.3.44)
Gene namesi
Name:mdlA
Ordered Locus Names:BU479
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei53 – 73HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei134 – 154HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei155 – 175HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei247 – 267HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei280 – 300HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000924931 – 589Multidrug resistance-like ATP-binding protein MdlAAdd BLAST589

Interactioni

Protein-protein interaction databases

STRINGi107806.BU479.

Structurei

3D structure databases

ProteinModelPortaliP57551.
SMRiP57551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 303ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST286
Domaini334 – 571ABC transporterPROSITE-ProRule annotationAdd BLAST238

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi519 – 522Poly-Lys4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK18889.
OMAiRMAVDMR.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P57551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFNQLRWF FVREWKRYLG AILLLIIIAT LQLLPPKIVG VLIDLIIKKN
60 70 80 90 100
MHGVQILPWI LIIFLVAVIV YILRYLWRIL LFGASYQLAT ELRVKFYTYL
110 120 130 140 150
SQQSQIFFLK NRTGDLIARA TNDVDRVVFA AGEGVLTLVD SLVMGFSVLI
160 170 180 190 200
VMSTQISFLL TIISLIPMPI MAILIKKYGK ELHETFRHAQ ISFSLLNNQT
210 220 230 240 250
QEILTSIRMI RAFGLEKNQS NKFNIITRNT GKKNMEVAKI DARFDPVIYL
260 270 280 290 300
SVAFSNLLAI IGGGWLVWNN QISIGQLTSF IMYLGLMIWP MLALAWMFNI
310 320 330 340 350
VERGSAAWDR IHSIINKKLY IEDGKNNIPP YPGILNINIK KFYYPNNQKP
360 370 380 390 400
SLKDIRILIK PGNTLGICGP TGSGKSTLLM LIQRQFNFKK EEIHYHSLSL
410 420 430 440 450
LEIKIDDWRR RIAVVNQTSF LFSDTISNNI SLGKPNASQK EIEEVAKLAD
460 470 480 490 500
VHKDIIDLPE RYETQVGERG VMLSGGQKQR VCIARALLLN AEILILDDAL
510 520 530 540 550
SAVDAQTENN ILKNINEWKK KKHSLIITTH RLSALINSDE IIVIKSGSII
560 570 580
QRGNHLKLIQ EKNWYKSMYY YQQSEIELED NEKTGEKNL
Length:589
Mass (Da):67,522
Last modified:December 1, 2000 - v1
Checksum:iAF736FA2FA60A56A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13176.1.
RefSeqiNP_240290.1. NC_002528.1.
WP_010896138.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13176; BAB13176; BAB13176.
GeneIDi1109826.
KEGGibuc:BU479.
PATRICifig|107806.10.peg.488.

Similar proteinsi

Entry informationi

Entry nameiMDLA_BUCAI
AccessioniPrimary (citable) accession number: P57551
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 25, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families