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P57540

- CYOE_BUCAI

UniProt

P57540 - CYOE_BUCAI

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Protein

Protoheme IX farnesyltransferase

Gene
cyoE, BU468
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. protoheme IX farnesyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. heme O biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-468-MONOMER.
UniPathwayiUPA00834; UER00712.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferase (EC:2.5.1.-)
Alternative name(s):
Heme B farnesyltransferase
Heme O synthase
Gene namesi
Name:cyoE
Ordered Locus Names:BU468
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Reviewed predictionAdd
BLAST
Transmembranei36 – 5621Helical; Reviewed predictionAdd
BLAST
Transmembranei80 – 10021Helical; Reviewed predictionAdd
BLAST
Transmembranei107 – 12721Helical; Reviewed predictionAdd
BLAST
Transmembranei133 – 15321Helical; Reviewed predictionAdd
BLAST
Transmembranei163 – 18321Helical; Reviewed predictionAdd
BLAST
Transmembranei209 – 22921Helical; Reviewed predictionAdd
BLAST
Transmembranei232 – 25221Helical; Reviewed predictionAdd
BLAST
Transmembranei265 – 28521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Protoheme IX farnesyltransferaseUniRule annotationPRO_0000162898Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57540.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0109.
HOGENOMiHOG000237290.
KOiK02301.
OMAiFATSLWW.
OrthoDBiEOG6DVJQB.

Family and domain databases

HAMAPiMF_00154. CyoE_CtaB.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57540-1 [UniParc]FASTAAdd to Basket

« Hide

MFKNYIEITK PGIIIGNSTL ITGGFLFASR HAAFNYVLFI YTILGASLVI    50
ASACVFNNLI DIDIDKKMKR TSNRVLSKKL LPVFSVFNFA IFLGVLGLSI 100
LGCLVNFISM SLAVFGFFIY VVLYTMFYKR RSFYSTFIGS FSGSTPSVIG 150
YTAVSNTIDI CSILLFVIVI FWQMSHFYSI SIMRIKDYRE AKIPVFSVVK 200
GVAITKKHIF FYVLNFSFFS SLFTFLGYLS YNFLLLSSIV NFYWSFLSYS 250
NIKKNNDKKN ARKLFYFSII VIVFFNFLIS IDVFF 285
Length:285
Mass (Da):32,686
Last modified:December 1, 2000 - v1
Checksum:i46504A297D4A16EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13165.1.
RefSeqiNP_240279.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13165; BAB13165; BAB13165.
GeneIDi1109815.
KEGGibuc:BU468.
PATRICi21244478. VBIBucAph127364_0477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13165.1 .
RefSeqi NP_240279.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57540.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13165 ; BAB13165 ; BAB13165 .
GeneIDi 1109815.
KEGGi buc:BU468.
PATRICi 21244478. VBIBucAph127364_0477.

Phylogenomic databases

eggNOGi COG0109.
HOGENOMi HOG000237290.
KOi K02301.
OMAi FATSLWW.
OrthoDBi EOG6DVJQB.

Enzyme and pathway databases

UniPathwayi UPA00834 ; UER00712 .
BioCyci BAPH107806:GBZJ-468-MONOMER.

Family and domain databases

HAMAPi MF_00154. CyoE_CtaB.
InterProi IPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view ]
Pfami PF01040. UbiA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01473. cyoE_ctaB. 1 hit.
PROSITEi PS00943. UBIA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiCYOE_BUCAI
AccessioniPrimary (citable) accession number: P57540
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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