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P57540 (CYOE_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protoheme IX farnesyltransferase

EC=2.5.1.-
Alternative name(s):
Heme B farnesyltransferase
Heme O synthase
Gene names
Name:cyoE
Ordered Locus Names:BU468
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group By similarity. HAMAP-Rule MF_00154

Pathway

Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1. HAMAP-Rule MF_00154

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00154.

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature By similarity.

Sequence similarities

Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.

Ontologies

Keywords
   Biological processHeme biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheme O biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotoheme IX farnesyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Protoheme IX farnesyltransferase HAMAP-Rule MF_00154
PRO_0000162898

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane36 – 5621Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane265 – 28521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P57540 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 46504A297D4A16EF

FASTA28532,686
        10         20         30         40         50         60 
MFKNYIEITK PGIIIGNSTL ITGGFLFASR HAAFNYVLFI YTILGASLVI ASACVFNNLI 

        70         80         90        100        110        120 
DIDIDKKMKR TSNRVLSKKL LPVFSVFNFA IFLGVLGLSI LGCLVNFISM SLAVFGFFIY 

       130        140        150        160        170        180 
VVLYTMFYKR RSFYSTFIGS FSGSTPSVIG YTAVSNTIDI CSILLFVIVI FWQMSHFYSI 

       190        200        210        220        230        240 
SIMRIKDYRE AKIPVFSVVK GVAITKKHIF FYVLNFSFFS SLFTFLGYLS YNFLLLSSIV 

       250        260        270        280 
NFYWSFLSYS NIKKNNDKKN ARKLFYFSII VIVFFNFLIS IDVFF 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB13165.1.
RefSeqNP_240279.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57540.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB13165; BAB13165; BAB13165.
GeneID1109815.
KEGGbuc:BU468.
PATRIC21244478. VBIBucAph127364_0477.

Phylogenomic databases

eggNOGCOG0109.
HOGENOMHOG000237290.
KOK02301.
OMAVIDYPLF.
OrthoDBEOG6DVJQB.
ProtClustDBPRK04375.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-468-MONOMER.
UniPathwayUPA00834; UER00712.

Family and domain databases

HAMAPMF_00154. CyoE_CtaB.
InterProIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01473. cyoE_ctaB. 1 hit.
PROSITEPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYOE_BUCAI
AccessionPrimary (citable) accession number: P57540
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names