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P57537 (ISPA_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Farnesyl diphosphate synthase
Short name=FPP synthase
EC=2.5.1.10
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Geranyltranstransferase
Gene names
Name:ispA
Ordered Locus Names:BU465
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiongeranyltranstransferase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Farnesyl diphosphate synthase
PRO_0000123988

Sites

Metal binding841Magnesium 1 By similarity
Metal binding841Magnesium 2 By similarity
Metal binding901Magnesium 1 By similarity
Metal binding901Magnesium 2 By similarity
Metal binding2231Magnesium 3 By similarity
Binding site451Isopentenyl diphosphate By similarity
Binding site481Isopentenyl diphosphate By similarity
Binding site771Isopentenyl diphosphate By similarity
Binding site951Geranyl diphosphate By similarity
Binding site961Isopentenyl diphosphate By similarity
Binding site1811Geranyl diphosphate By similarity
Binding site1821Geranyl diphosphate By similarity
Binding site2201Geranyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P57537 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 228B31A6DBCD6445

FASTA28232,332
        10         20         30         40         50         60 
MHFFHLYERY KHRINQKLFY TLNQLPFQKS SLLKAMKYSV FSGSKRLRSS LIYSTGDVFK 

        70         80         90        100        110        120 
VNITTLDVIS TAIEFIHSYS LIHDDLPCMD NDNFRRGKIS CHVKYGESTS LLAGDALQSL 

       130        140        150        160        170        180 
AFNILSNSFM PNVSNLKRIK MISELSYSIG SSGMCMGQNL DLEAEKKDVN LSELEIINLY 

       190        200        210        220        230        240 
KTSFLMRSAV RLVYFSSNNF SKSILSILDL FSISIGLAFQ IQDDILDFKK DSVKTDNKKI 

       250        260        270        280 
IKKHTYPLII GLDESRKKIK QLHKKSFLAL NSLKKKISIP TY

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed: 10993077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000003 Genomic DNA. Translation: BAB13162.1.
RefSeqNP_240276.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57537.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002876; EBBUCP00000002652; EBBUCG00000002876.
GeneID1109812.
GenomeReviewsGene locus BU465 in contig BA000003_GR.
KEGGbuc:BU465.
PATRIC21244472. VBIBucAph127364_0474.

Phylogenomic databases

GeneTreeEBGT00050000008059.
HOGENOMHBG732667.
OMANELCTEM.
PhylomeDBP57537.
ProtClustDBCLSK316270.

Enzyme and pathway databases

BioCycBSP107806:BU465-MONOMER.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
KOK00795.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPA_BUCAI
AccessionPrimary (citable) accession number: P57537
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

SIMILARITY comments

Index of protein domains and families

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