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P57533

- RIBD1_BUCAI

UniProt

P57533 - RIBD1_BUCAI

Protein

Diaminohydroxyphosphoribosylamino-pyrimidine deaminase

Gene

ribD1

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (11 Feb 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3.

    Cofactori

    Binds 1 zinc ion.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi50 – 501Zinc; catalyticBy similarity
    Active sitei52 – 521Proton donorBy similarity
    Metal bindingi75 – 751Zinc; catalyticBy similarity
    Metal bindingi84 – 841Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. diaminohydroxyphosphoribosylaminopyrimidine deaminase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. oxidation-reduction process Source: InterPro
    2. riboflavin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-461-MONOMER.
    UniPathwayiUPA00275; UER00401.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminohydroxyphosphoribosylamino-pyrimidine deaminase (EC:3.5.4.26)
    Short name:
    DRAP deaminase
    Alternative name(s):
    Riboflavin-specific deaminase
    Gene namesi
    Name:ribD1
    Ordered Locus Names:BU461
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 147147Diaminohydroxyphosphoribosylamino-pyrimidine deaminasePRO_0000171725Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57533.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0117.
    HOGENOMiHOG000085050.
    KOiK01498.
    OMAiLEPCSFV.
    OrthoDBiEOG66F07R.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR004794. Eubact_RibD.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00326. eubact_ribD. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57533-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNDIFYMKRA IELSKLGEFT TAPNPNVGCV IVKNNIIVGE GWHEQAGKNH    50
    AEINALIMAG EKAQGGTAYV TLEPCNHFGK TPPCCNALIK SGINRVVISN 100
    IDPNPKISGN GILYLKKHGI CVKTGLLSKE SKQYNKGFFK RMKTGFP 147
    Length:147
    Mass (Da):16,049
    Last modified:February 11, 2002 - v2
    Checksum:i7E4753A37EDFE506
    GO

    Sequence cautioni

    The sequence BAB13158.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13158.1. Different initiation.
    RefSeqiNP_240272.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13158; BAB13158; BAB13158.
    GeneIDi1109808.
    KEGGibuc:BU461.
    PATRICi21244464. VBIBucAph127364_0470.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13158.1 . Different initiation.
    RefSeqi NP_240272.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57533.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13158 ; BAB13158 ; BAB13158 .
    GeneIDi 1109808.
    KEGGi buc:BU461.
    PATRICi 21244464. VBIBucAph127364_0470.

    Phylogenomic databases

    eggNOGi COG0117.
    HOGENOMi HOG000085050.
    KOi K01498.
    OMAi LEPCSFV.
    OrthoDBi EOG66F07R.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00401 .
    BioCyci BAPH107806:GBZJ-461-MONOMER.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR004794. Eubact_RibD.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00326. eubact_ribD. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiRIBD1_BUCAI
    AccessioniPrimary (citable) accession number: P57533
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: February 11, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3