Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Diaminohydroxyphosphoribosylamino-pyrimidine deaminase

Gene

ribD1

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi50 – 501Zinc; catalyticBy similarity
Active sitei52 – 521Proton donorBy similarity
Metal bindingi75 – 751Zinc; catalyticBy similarity
Metal bindingi84 – 841Zinc; catalyticBy similarity

GO - Molecular functioni

  1. diaminohydroxyphosphoribosylaminopyrimidine deaminase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: InterPro
  2. riboflavin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-461-MONOMER.
UniPathwayiUPA00275; UER00401.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminohydroxyphosphoribosylamino-pyrimidine deaminase (EC:3.5.4.26)
Short name:
DRAP deaminase
Alternative name(s):
Riboflavin-specific deaminase
Gene namesi
Name:ribD1
Ordered Locus Names:BU461
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Diaminohydroxyphosphoribosylamino-pyrimidine deaminasePRO_0000171725Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0117.
HOGENOMiHOG000085050.
KOiK01498.
OMAiALPECQP.
OrthoDBiEOG66F07R.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR004794. Eubact_RibD.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00326. eubact_ribD. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDIFYMKRA IELSKLGEFT TAPNPNVGCV IVKNNIIVGE GWHEQAGKNH
60 70 80 90 100
AEINALIMAG EKAQGGTAYV TLEPCNHFGK TPPCCNALIK SGINRVVISN
110 120 130 140
IDPNPKISGN GILYLKKHGI CVKTGLLSKE SKQYNKGFFK RMKTGFP
Length:147
Mass (Da):16,049
Last modified:February 11, 2002 - v2
Checksum:i7E4753A37EDFE506
GO

Sequence cautioni

The sequence BAB13158.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13158.1. Different initiation.
RefSeqiNP_240272.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13158; BAB13158; BAB13158.
GeneIDi1109808.
KEGGibuc:BU461.
PATRICi21244464. VBIBucAph127364_0470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13158.1. Different initiation.
RefSeqiNP_240272.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57533.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB13158; BAB13158; BAB13158.
GeneIDi1109808.
KEGGibuc:BU461.
PATRICi21244464. VBIBucAph127364_0470.

Phylogenomic databases

eggNOGiCOG0117.
HOGENOMiHOG000085050.
KOiK01498.
OMAiALPECQP.
OrthoDBiEOG66F07R.

Enzyme and pathway databases

UniPathwayiUPA00275; UER00401.
BioCyciBAPH107806:GBZJ-461-MONOMER.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR004794. Eubact_RibD.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00326. eubact_ribD. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiRIBD1_BUCAI
AccessioniPrimary (citable) accession number: P57533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: January 7, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.