P57532 (THIL_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiamine-monophosphate kinase
Short name=Thiamine-phosphate kinase
EC=2.7.4.16

Gene names

Name:	thiL
Ordered Locus Names:	BU460

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thiamine phosphate = ADP + thiamine diphosphate.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.
Sequence similarities	Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamine-phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Thiamine-monophosphate kinase		PRO_0000096192

Sequences

	Sequence		Length	Mass (Da)
	P57532 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: FAF4CF38C0A3ACE1	FASTA	323	36,391
	10 20 30 40 50 60 MKYTEFEIIS KYFKRNQKKD VNEIKGIGDD SALIKIPKNN ILAISTDTLV EGTHFLKNIS 70 80 90 100 110 120 PEDLGYKTVA VNLSDLAAMG AEPKWTTLSI TMPESNNIWL KKFSSSFFKI LNKYNVRLIG 130 140 150 160 170 180 GDTNRGSLSI TLSMYGLLKK QIALLRSNAN IGDLIYVTGT LGESAAGLFL LKKNIFIKNV 190 200 210 220 230 240 NIRNYLIKKH LNPIPRVSEG MALRKIANAA IDLSDGLIAD LDHILNDSQC GANINLNKIP 250 260 270 280 290 300 ISKVLIDNFQ SQNYLNWALN VGEDYELCFT ISKKNIDKLK IIKKKFLVNF TCIGYITPIE 310 320 QGFNLFDNQK KIIFKKKGFN HFD

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB13157.1.
RefSeq	NP_240271.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57532.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000002896; EBBUCP00000002672; EBBUCG00000002896.
GeneID	1109807.
GenomeReviews	Gene locus BU460 in contig BA000003_GR.
KEGG	buc:BU460.
PATRIC	21244462. VBIBucAph127364_0469.
Phylogenomic databases
GeneTree	EBGT00050000008007.
HOGENOM	HBG577902.
OMA	MGAEPAW.
PhylomeDB	P57532.
ProtClustDB	CLSK316267.
Enzyme and pathway databases
BioCyc	BSP107806:BU460-MONOMER.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR006283. ThiL. [Graphical view]
KO	K00946.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF005303. Thiam_monoph_kin. 1 hit.
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR01379. ThiL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIL_BUCAI

Accession

Primary (citable) accession number: P57532

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program