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Protein

Membrane-bound lytic murein transglycosylase A homolog

Gene

mltA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity).By similarity

Catalytic activityi

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

CAZyiGH102. Glycoside Hydrolase Family 102.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lytic murein transglycosylase A homolog (EC:4.2.2.n1)
Alternative name(s):
Murein hydrolase A
Gene namesi
Name:mltA
Ordered Locus Names:BU458
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi


    Note: In closely related bacteria this protein is attached to the outer membrane by a lipid anchor. This is apparently not the case here.

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001965661 – 359Membrane-bound lytic murein transglycosylase A homologAdd BLAST359

Interactioni

Protein-protein interaction databases

STRINGi107806.BU458.

Structurei

3D structure databases

ProteinModelPortaliP57531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CA3. Bacteria.
COG2821. LUCA.
HOGENOMiHOG000278098.
KOiK08304.
OMAiKREDMSM.

Family and domain databases

Gene3Di2.40.40.10. 2 hits.
InterProiIPR010611. 3D_dom.
IPR005300. Lytic_transglycosylase_MltA.
IPR026044. MltA.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF06725. 3D. 1 hit.
PF03562. MltA. 1 hit.
[Graphical view]
PIRSFiPIRSF019422. MltA. 1 hit.
SMARTiSM00925. MltA. 1 hit.
[Graphical view]
SUPFAMiSSF50685. SSF50685. 1 hit.

Sequencei

Sequence statusi: Complete.

P57531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKKIIKTII FFSLFFLFEK SYAYININQG QQYEKKLIQN LTKIKQINIK
60 70 80 90 100
KKIINAESFY IQVEKIKKFS PSLYLKNEST YKTILKWLKK NSNINELNEF
110 120 130 140 150
GINLFQMKGI DNYGNVKITG YYTPIVQARK IKKNNFKYPI YSMPYHLKKN
160 170 180 190 200
EPLPKRKDIY NGVLDKKYIL AYSNSLIDNF IMEIQGSAFI DYGNKKKLIF
210 220 230 240 250
FSYAGKNGWP YKSIGQILIN RGDIEKKNMS MQAINKWFTK HTNKEIQDLF
260 270 280 290 300
EKNESFVFFK ETKKKQVYGA SAVPLIAQTS VAADNSIIKK GSVILLKIPI
310 320 330 340 350
LDQNGVFLNK YEMRLVIALD VGGAIKGHHF DIYEGIGTKA SILSGYYNHY

GYAWILNKK
Length:359
Mass (Da):41,773
Last modified:March 1, 2001 - v1
Checksum:i24E12A2778D351AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13155.1.
RefSeqiNP_240269.1. NC_002528.1.
WP_009874410.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13155; BAB13155; BAB13155.
GeneIDi1109805.
KEGGibuc:BU458.
PATRICi21244458. VBIBucAph127364_0467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13155.1.
RefSeqiNP_240269.1. NC_002528.1.
WP_009874410.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi107806.BU458.

Protein family/group databases

CAZyiGH102. Glycoside Hydrolase Family 102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB13155; BAB13155; BAB13155.
GeneIDi1109805.
KEGGibuc:BU458.
PATRICi21244458. VBIBucAph127364_0467.

Phylogenomic databases

eggNOGiENOG4105CA3. Bacteria.
COG2821. LUCA.
HOGENOMiHOG000278098.
KOiK08304.
OMAiKREDMSM.

Family and domain databases

Gene3Di2.40.40.10. 2 hits.
InterProiIPR010611. 3D_dom.
IPR005300. Lytic_transglycosylase_MltA.
IPR026044. MltA.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF06725. 3D. 1 hit.
PF03562. MltA. 1 hit.
[Graphical view]
PIRSFiPIRSF019422. MltA. 1 hit.
SMARTiSM00925. MltA. 1 hit.
[Graphical view]
SUPFAMiSSF50685. SSF50685. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMLTA_BUCAI
AccessioniPrimary (citable) accession number: P57531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.