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P57526

- ALF_BUCAI

UniProt

P57526 - ALF_BUCAI

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Protein

Fructose-bisphosphate aldolase class 2

Gene

fbaA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611Glyceraldehyde 3-phosphateBy similarity
Active sitei109 – 1091Proton donorBy similarity
Metal bindingi110 – 1101Zinc 1; catalyticBy similarity
Metal bindingi144 – 1441Zinc 2By similarity
Metal bindingi174 – 1741Zinc 2By similarity
Metal bindingi226 – 2261Zinc 1; catalyticBy similarity
Binding sitei227 – 2271Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi264 – 2641Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-451-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 2 (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Fructose-bisphosphate aldolase class II
Gene namesi
Name:fbaA
Synonyms:fba
Ordered Locus Names:BU451
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Fructose-bisphosphate aldolase class 2PRO_0000178708Add
BLAST

Proteomic databases

PRIDEiP57526.

Structurei

3D structure databases

ProteinModelPortaliP57526.
SMRiP57526. Positions 3-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2673Dihydroxyacetone phosphate bindingBy similarity
Regioni286 – 2894Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227794.
KOiK01624.
OMAiHNSLDFV.
OrthoDBiEOG69GZPB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57526-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNILNVIRPG VMNGDEARIV FELAKKKQFA IPAVNCIGTD SINAVLETAA
60 70 80 90 100
RVKSPIIIQF SHGGASFIAG YKKKLSENQE QAIQGAVSGA QHVHLMAKHY
110 120 130 140 150
EIPVILHTDH CPKETLSWID GLLEVGQNYY FNNNRPLFTS HMIDLSKESL
160 170 180 190 200
EENISTCKKY FKRIKNINMM LEIELGCTGG EEDGIDNTKI DKKLLYTQPQ
210 220 230 240 250
DVNYAYEELN TISKNFSIAA SFGNIHGVYQ PGNIDLRPII LKNSQEFVSS
260 270 280 290 300
KHNLEKNPLN LVFHGGSGSN LKEIKESIQY GVVKMNIDTD IQWAAWKGVL
310 320 330 340 350
DFYKQNKEFL QHQLGNTTNK HKPNKKYYDP RTWIRKSQES ISIRLEQSFK

ELNSFNIL
Length:358
Mass (Da):40,663
Last modified:December 1, 2000 - v1
Checksum:iAB7A47FBF80D2FC2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13149.1.
RefSeqiNP_240263.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13149; BAB13149; BAB13149.
GeneIDi1109799.
KEGGibuc:BU451.
PATRICi21244444. VBIBucAph127364_0461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13149.1 .
RefSeqi NP_240263.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57526.
SMRi P57526. Positions 3-358.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P57526.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13149 ; BAB13149 ; BAB13149 .
GeneIDi 1109799.
KEGGi buc:BU451.
PATRICi 21244444. VBIBucAph127364_0461.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227794.
KOi K01624.
OMAi HNSLDFV.
OrthoDBi EOG69GZPB.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci BAPH107806:GBZJ-451-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiALF_BUCAI
AccessioniPrimary (citable) accession number: P57526
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 1, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3