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P57519

- SYL_BUCAI

UniProt

P57519 - SYL_BUCAI

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-444-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BU444
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligasePRO_0000151987Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57519-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKEYSPKKI ENYVQEFWKK NKTFEVKEDP KKEKYYCLPM LPYPSGKLHM
60 70 80 90 100
GHVRNYTISD VISRYQRMLG KNVLQPMGWD AFGLPAEEAA IRNNTDPFSW
110 120 130 140 150
TQKNIKYMKK QLQSLGFSYD WSREITTCHP EYYHWEQWFF TKLYEKKLVY
160 170 180 190 200
KKNSLVNWCS YDKTVLANEQ VIDGCCWRCQ NKIRIKQIPQ WFIKIRNYAE
210 220 230 240 250
SLYQDLKKLT HWPENVKNMQ RNWIGRIKGF EITLNVFNTC QKLKVFTQRL
260 270 280 290 300
DLLMGVTYIS ISSCHKLSIN LSKKNELIKK FIKKYRYISQ EEQYKVKYTG
310 320 330 340 350
INTNLFVVHP ITKKTIPIWI SNATHIEYGT NAVLSIPGHN ENDWNFAVKN
360 370 380 390 400
NLKIKYVIFN PDHQEPKLYT SFLDIKGTLF NSQEFNGLNL KDGTEKIKKI
410 420 430 440 450
LYKKKILKEK INYKLQDWCI SRQRYWGTPI PMAKFKNGKM IPIPENQLPV
460 470 480 490 500
VLPKIRKNTN LLQQAINFNS KWAEIFIHGK HAIREIDTFD TFMESSWYYA
510 520 530 540 550
RYTCPNFNTG MIDSIASKYW LPVDQYIGGI EHAIMHLMYF RFYHKLLRDF
560 570 580 590 600
KLVDFDEPVK NLLCQGMVLS EAFYKIDSNS QRKWFNSSSV LIKRNTKGEI
610 620 630 640 650
IESHTQKGEK LIYAGMIKMS KSKNNGIEPE LIIQRYGADT IRLFIMFSAP
660 670 680 690 700
VESDLEWKES GLKGIYRFLK KLWMLIFNYI DIKNTHKKIN FDFLNHQQSE
710 720 730 740 750
LRYQLHKTIA KVSDDIGRRQ TFNTAISEIM KLVNQLSKAP IKEEQDKSIM
760 770 780 790 800
RESLICIIKM LYPFTPHFCF FVWNYFNNHS SIDNEKWPIF QKDILSKKYS
810 820 830 840 850
TIVAQINGKK RCATKISDSL TKEEIFLYIQ NQPIIKKYLE DVDIKKIIYI

PKKIINFVT
Length:859
Mass (Da):102,170
Last modified:December 1, 2000 - v1
Checksum:i43DBB88CD4020975
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13142.1.
RefSeqiNP_240256.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13142; BAB13142; BAB13142.
GeneIDi1109792.
KEGGibuc:BU444.
PATRICi21244430. VBIBucAph127364_0454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13142.1 .
RefSeqi NP_240256.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57519.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13142 ; BAB13142 ; BAB13142 .
GeneIDi 1109792.
KEGGi buc:BU444.
PATRICi 21244430. VBIBucAph127364_0454.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-444-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiSYL_BUCAI
AccessioniPrimary (citable) accession number: P57519
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3