P57505 (DSBA_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiol:disulfide interchange protein DsbA

Gene names

Name:	dsbA
Ordered Locus Names:	BU430

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily.

Ontologies

Keywords
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 212	193	Thiol:disulfide interchange protein DsbA		PRO_0000034248
Amino acid modifications
	Disulfide bond	49 ↔ 52		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57505 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 42DC3FD02DC2331D	FASTA	212	25,159
	10 20 30 40 50 60 MKKILIILCI LILSCNVFSC EFKNGREYTE KHKVISNIPS IIEFFSFFCP YCYEFEKTYD 70 80 90 100 110 120 TQYLIEKKIK KNINIQKYHV SFLGGKLGYV LTKSWIIAQQ MGIEKKIVLP IFKGIQETYT 130 140 150 160 170 180 INNLDDIKKI FKEKAGVSES KFNSFWNSLT IKILISKQEE DIRKYNLKNI PTMLINEKYV 190 200 210 IDYSKIEEIF KDSFAEKYTK LIQFLINKKE KI

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB13128.1.
RefSeq	NP_240242.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57505.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000003154; EBBUCP00000002930; EBBUCG00000003154.
GeneID	1109778.
GenomeReviews	Gene locus BU430 in contig BA000003_GR.
KEGG	buc:BU430.
PATRIC	21244400. VBIBucAph127364_0439.
Phylogenomic databases
GeneTree	EBGT00050000008080.
HOGENOM	HBG680642.
OMA	MFEAVQK.
PhylomeDB	P57505.
ProtClustDB	CLSK316169.
Enzyme and pathway databases
BioCyc	BSP107806:BU430-MONOMER.
Family and domain databases
InterPro	IPR001853. DSBA-like_thioredoxin_dom. IPR023205. Thiol:disulphide_interchange. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K03673.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PIRSF	PIRSF001488. Tdi_protein. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_BUCAI

Accession

Primary (citable) accession number: P57505

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program