Reviewed, UniProtKB/Swiss-Prot P57505 (DSBA_BUCAI)

Names and origin

Protein names

Recommended name:
    Thiol:disulfide interchange protein dsbA

Gene names

Name:	dsbA
Ordered Locus Names:	BU430

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [Complete proteome] [HAMAP]

Taxonomic identifier

118099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily.

Ontologies

Keywords
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 212	193	Thiol:disulfide interchange protein dsbA		PRO_0000034248
Amino acid modifications
	Disulfide bond	49 ↔ 52		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57505-1 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 42DC3FD02DC2331D	FASTA	212	25,159
	10 20 30 40 50 60 MKKILIILCI LILSCNVFSC EFKNGREYTE KHKVISNIPS IIEFFSFFCP YCYEFEKTYD 70 80 90 100 110 120 TQYLIEKKIK KNINIQKYHV SFLGGKLGYV LTKSWIIAQQ MGIEKKIVLP IFKGIQETYT 130 140 150 160 170 180 INNLDDIKKI FKEKAGVSES KFNSFWNSLT IKILISKQEE DIRKYNLKNI PTMLINEKYV 190 200 210 IDYSKIEEIF KDSFAEKYTK LIQFLINKKE KI

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tokyo 1998.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000003 Genomic DNA. Translation: BAB13128.1.
RefSeq	NP_240242.1.
3D structure databases
HSSP	HSSP built from PDB template 1A23 based on UniProtKB P24991.
ModBase	Search...
Genome annotation databases
GeneID	1109778.
GenomeReviews	Gene locus BU430 in contig BA000003_GR.
KEGG	buc:BU430.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P57505.
OMA	P57505. GVEDKMV.
Enzyme and pathway databases
BioCyc	BSP107806:BU430-MON.
Family and domain databases
InterPro	IPR001853. OxRdtase_DSBA. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_BUCAI

Accession

Primary (citable) accession number: P57505

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)