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P57501

- CYSH_BUCAI

UniProt

P57501 - CYSH_BUCAI

Protein

Phosphoadenosine phosphosulfate reductase

Gene

cysH

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Reduction of activated sulfate into sulfite.By similarity

    Catalytic activityi

    Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.

    Pathwayi

    GO - Molecular functioni

    1. phosphoadenylyl-sulfate reductase (thioredoxin) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cysteine biosynthetic process Source: InterPro
    2. hydrogen sulfide biosynthetic process Source: UniProtKB-UniPathway
    3. methionine biosynthetic process Source: InterPro
    4. sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-426-MONOMER.
    UniPathwayiUPA00140; UER00206.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoadenosine phosphosulfate reductase (EC:1.8.4.8)
    Alternative name(s):
    3'-phosphoadenylylsulfate reductase
    PAPS reductase, thioredoxin dependent
    PAPS sulfotransferase
    PAdoPS reductase
    Gene namesi
    Name:cysH
    Ordered Locus Names:BU426
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Phosphoadenosine phosphosulfate reductasePRO_0000100628Add
    BLAST

    Proteomic databases

    PRIDEiP57501.

    Structurei

    3D structure databases

    ProteinModelPortaliP57501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PAPS reductase family. CysH subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0175.
    HOGENOMiHOG000249396.
    KOiK00390.
    OMAiQSPAWQE.
    OrthoDBiEOG6V1M7D.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00063. CysH.
    InterProiIPR004511. PAPS/APS_Rdtase.
    IPR002500. PAPS_reduct.
    IPR011800. PAPS_reductase_CysH.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01507. PAPS_reduct. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00434. cysH. 1 hit.
    TIGR02057. PAPS_reductase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P57501-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKFYIENIN LLNSEKKNNI LSELNLLLSN YSAEERISWA LSHLPHTQIM    50
    SSSFGIQSTV LLHLIIKKKP DIPVILIDTG YLFPETYNFI DFLTNKFHLN 100
    LKVFRSTISS AWQEARYGKL WEKGIEGIDF YNNINKVQPM NFALNELSVQ 150
    TWFAGLRHDQ SKSRNLLPYL SIKKGIFKIL PILDWSKDKI KDYLKENNLD 200
    THPLYNNGYS SVGDTHTTKK HMPGMLEEET RFFGLKRECG LHEN 244
    Length:244
    Mass (Da):28,402
    Last modified:December 1, 2000 - v1
    Checksum:iED7ADB9778927DDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13124.1.
    RefSeqiNP_240238.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13124; BAB13124; BAB13124.
    GeneIDi1109774.
    KEGGibuc:BU426.
    PATRICi21244392. VBIBucAph127364_0435.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13124.1 .
    RefSeqi NP_240238.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57501.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P57501.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13124 ; BAB13124 ; BAB13124 .
    GeneIDi 1109774.
    KEGGi buc:BU426.
    PATRICi 21244392. VBIBucAph127364_0435.

    Phylogenomic databases

    eggNOGi COG0175.
    HOGENOMi HOG000249396.
    KOi K00390.
    OMAi QSPAWQE.
    OrthoDBi EOG6V1M7D.

    Enzyme and pathway databases

    UniPathwayi UPA00140 ; UER00206 .
    BioCyci BAPH107806:GBZJ-426-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00063. CysH.
    InterProi IPR004511. PAPS/APS_Rdtase.
    IPR002500. PAPS_reduct.
    IPR011800. PAPS_reductase_CysH.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01507. PAPS_reduct. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00434. cysH. 1 hit.
    TIGR02057. PAPS_reductase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiCYSH_BUCAI
    AccessioniPrimary (citable) accession number: P57501
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3