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P57485

- GSH1_BUCAI

UniProt

P57485 - GSH1_BUCAI

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Protein

Glutamate--cysteine ligase

Gene

gshA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-cysteine ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutathione biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Glutathione biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-407-MONOMER.
UniPathwayiUPA00142; UER00209.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--cysteine ligase (EC:6.3.2.2)
Alternative name(s):
Gamma-ECS
Short name:
GCS
Gamma-glutamylcysteine synthetase
Gene namesi
Name:gshA
Ordered Locus Names:BU407
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Glutamate--cysteine ligasePRO_0000192520Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2918.
HOGENOMiHOG000266224.
KOiK01919.
OMAiWPMSMPC.
OrthoDBiEOG6BKJ7H.

Family and domain databases

HAMAPiMF_00578. Glu_cys_ligase.
InterProiIPR007370. Glu_cys_ligase.
IPR006334. Glut_cys_ligase.
[Graphical view]
PfamiPF04262. Glu_cys_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01434. glu_cys_ligase. 1 hit.

Sequencei

Sequence statusi: Complete.

P57485 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIEDISKKIA WLKKNPKMLK GIFRGIERET LRIQKNGHFS KTIHPYLIGS
60 70 80 90 100
SLTHKWITTD FSENLLEFIT PTSDNIDYLL SFLTDLHSFT ASKIKNERMW
110 120 130 140 150
PFSIPYCFND QTNIQIAQYG KSNIGKMKTT YRIGLKNRYG DLINTISGIH
160 170 180 190 200
YNFSLPLFFW TNWENNQNKK NNTDLISSGY LNLIRNYYRF GWIVPYLFGS
210 220 230 240 250
SPAISSFFLK NTKKKYKFKK NKEDIFYLPW STSLRLSDIG YSNTNILDLN
260 270 280 290 300
IMFNDFNEYI ESFQNALKTP SKKFINIGLK DEHGNFKQLN TNILQIENEL
310 320 330 340 350
YTQIRPKRKT KDGESLLEAL KNRGIEYVEI RSLDVNPFSP IGINKNQILL
360 370 380 390 400
LDLFLIWCAL IDSPKIDKTD FLLTTKNWER IIYEGRKPNQ KIYINNNNET
410 420 430 440 450
KTLIEIGQII FKDLNEIALI LDSNSNDLLY QKACKETQLF LKNPELTYSA
460 470 480 490 500
QCLNFLMTTG IKKTGLYLAN KYHEKFINKN YFNLNQSVLE QEVIRSHQKK
510
IEIEREDILS FEEYIRNK
Length:518
Mass (Da):60,979
Last modified:December 1, 2000 - v1
Checksum:iAC6659F1E2C50BD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13108.1.
RefSeqiNP_240222.1. NC_002528.1.
WP_010896101.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13108; BAB13108; BAB13108.
GeneIDi1109758.
KEGGibuc:BU407.
PATRICi21244354. VBIBucAph127364_0419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13108.1 .
RefSeqi NP_240222.1. NC_002528.1.
WP_010896101.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57485.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13108 ; BAB13108 ; BAB13108 .
GeneIDi 1109758.
KEGGi buc:BU407.
PATRICi 21244354. VBIBucAph127364_0419.

Phylogenomic databases

eggNOGi COG2918.
HOGENOMi HOG000266224.
KOi K01919.
OMAi WPMSMPC.
OrthoDBi EOG6BKJ7H.

Enzyme and pathway databases

UniPathwayi UPA00142 ; UER00209 .
BioCyci BAPH107806:GBZJ-407-MONOMER.

Family and domain databases

HAMAPi MF_00578. Glu_cys_ligase.
InterProi IPR007370. Glu_cys_ligase.
IPR006334. Glut_cys_ligase.
[Graphical view ]
Pfami PF04262. Glu_cys_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01434. glu_cys_ligase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiGSH1_BUCAI
AccessioniPrimary (citable) accession number: P57485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3