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P57485

- GSH1_BUCAI

UniProt

P57485 - GSH1_BUCAI

Protein

Glutamate--cysteine ligase

Gene

gshA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-cysteine ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutathione biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Glutathione biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-407-MONOMER.
    UniPathwayiUPA00142; UER00209.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--cysteine ligase (EC:6.3.2.2)
    Alternative name(s):
    Gamma-ECS
    Short name:
    GCS
    Gamma-glutamylcysteine synthetase
    Gene namesi
    Name:gshA
    Ordered Locus Names:BU407
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Glutamate--cysteine ligasePRO_0000192520Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57485.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2918.
    HOGENOMiHOG000266224.
    KOiK01919.
    OMAiWPMSMPC.
    OrthoDBiEOG6BKJ7H.

    Family and domain databases

    HAMAPiMF_00578. Glu_cys_ligase.
    InterProiIPR007370. Glu_cys_ligase.
    IPR006334. Glut_cys_ligase.
    [Graphical view]
    PfamiPF04262. Glu_cys_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01434. glu_cys_ligase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P57485-1 [UniParc]FASTAAdd to Basket

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    MIEDISKKIA WLKKNPKMLK GIFRGIERET LRIQKNGHFS KTIHPYLIGS    50
    SLTHKWITTD FSENLLEFIT PTSDNIDYLL SFLTDLHSFT ASKIKNERMW 100
    PFSIPYCFND QTNIQIAQYG KSNIGKMKTT YRIGLKNRYG DLINTISGIH 150
    YNFSLPLFFW TNWENNQNKK NNTDLISSGY LNLIRNYYRF GWIVPYLFGS 200
    SPAISSFFLK NTKKKYKFKK NKEDIFYLPW STSLRLSDIG YSNTNILDLN 250
    IMFNDFNEYI ESFQNALKTP SKKFINIGLK DEHGNFKQLN TNILQIENEL 300
    YTQIRPKRKT KDGESLLEAL KNRGIEYVEI RSLDVNPFSP IGINKNQILL 350
    LDLFLIWCAL IDSPKIDKTD FLLTTKNWER IIYEGRKPNQ KIYINNNNET 400
    KTLIEIGQII FKDLNEIALI LDSNSNDLLY QKACKETQLF LKNPELTYSA 450
    QCLNFLMTTG IKKTGLYLAN KYHEKFINKN YFNLNQSVLE QEVIRSHQKK 500
    IEIEREDILS FEEYIRNK 518
    Length:518
    Mass (Da):60,979
    Last modified:December 1, 2000 - v1
    Checksum:iAC6659F1E2C50BD4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13108.1.
    RefSeqiNP_240222.1. NC_002528.1.
    WP_010896101.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13108; BAB13108; BAB13108.
    GeneIDi1109758.
    KEGGibuc:BU407.
    PATRICi21244354. VBIBucAph127364_0419.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13108.1 .
    RefSeqi NP_240222.1. NC_002528.1.
    WP_010896101.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57485.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13108 ; BAB13108 ; BAB13108 .
    GeneIDi 1109758.
    KEGGi buc:BU407.
    PATRICi 21244354. VBIBucAph127364_0419.

    Phylogenomic databases

    eggNOGi COG2918.
    HOGENOMi HOG000266224.
    KOi K01919.
    OMAi WPMSMPC.
    OrthoDBi EOG6BKJ7H.

    Enzyme and pathway databases

    UniPathwayi UPA00142 ; UER00209 .
    BioCyci BAPH107806:GBZJ-407-MONOMER.

    Family and domain databases

    HAMAPi MF_00578. Glu_cys_ligase.
    InterProi IPR007370. Glu_cys_ligase.
    IPR006334. Glut_cys_ligase.
    [Graphical view ]
    Pfami PF04262. Glu_cys_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01434. glu_cys_ligase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiGSH1_BUCAI
    AccessioniPrimary (citable) accession number: P57485
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3