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P57481 (RLUD_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosomal large subunit pseudouridine synthase D

EC=5.4.99.23
Alternative name(s):
23S rRNA pseudouridine(1911/1915/1917) synthase
rRNA pseudouridylate synthase D
rRNA-uridine isomerase D
Gene names
Name:rluD
Ordered Locus Names:BU401
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA By similarity.

Catalytic activity

23S rRNA uridine(1911)/uridine(1915)/uridine(1917) = 23S rRNA pseudouridine(1911)/pseudouridine(1915)/pseudouridine(1917).

Sequence similarities

Belongs to the pseudouridine synthase RluA family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   Biological processrRNA processing
   LigandRNA-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

rRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Ribosomal large subunit pseudouridine synthase D
PRO_0000162684

Regions

Domain18 – 8770S4 RNA-binding

Sites

Active site1391 By similarity

Sequences

Sequence LengthMass (Da)Tools
P57481 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 6AC32A7F9260D890

FASTA31235,840
        10         20         30         40         50         60 
MKKIQLNSIA SSCSLSGQRL DLVLSKLFRE YSRSYLKKLI IMNQVLVNES IVNQPDKKIL 

        70         80         90        100        110        120 
GGETLTIHPF SKDLLVDIPE NIFLDIVYED SDILIINKPA GLVVHPGSGN KSGTILNALL 

       130        140        150        160        170        180 
YHYKNSKDLP RAGIVHRLDK DTSGLMVIAK NIFSYNHLLL LLKEKKIIRE YEGIVHGKMI 

       190        200        210        220        230        240 
AGGTINKPIM RHYNRRTCMM VHHLGKPSVT HYKVLSRFKF HTHIAIRLET GRTHQIRVHM 

       250        260        270        280        290        300 
LHIKYPLVGD PCYSGFKIQS NYRKDKKTNK IYKFPRQALH ANHLSLHHPI KKNVMSWTVP 

       310 
LPQDIQELLL KI 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB13104.1.
RefSeqNP_240218.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57481.
SMRP57481. Positions 79-310.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB13104; BAB13104; BAB13104.
GeneID1109754.
KEGGbuc:BU401.
PATRIC21244342. VBIBucAph127364_0415.

Phylogenomic databases

eggNOGCOG0564.
HOGENOMHOG000275919.
KOK06180.
OMAARTHFRR.
OrthoDBEOG6P070X.
ProtClustDBCLSK315917.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-401-MONOMER.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SMARTSM00363. S4. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00005. rluA_subfam. 1 hit.
PROSITEPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLUD_BUCAI
AccessionPrimary (citable) accession number: P57481
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 13, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names