ID   TLDD_BUCAI              Reviewed;         483 AA.
AC   P57478;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Metalloprotease TldD homolog;
DE            EC=3.4.-.-;
GN   Name=tldD; OrderedLocusNames=BU398;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: Probable metalloprotease. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase U62 family. {ECO:0000305}.
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DR   EMBL; BA000003; BAB13101.1; -; Genomic_DNA.
DR   RefSeq; NP_240215.1; NC_002528.1.
DR   RefSeq; WP_010896099.1; NC_002528.1.
DR   AlphaFoldDB; P57478; -.
DR   SMR; P57478; -.
DR   STRING; 563178.BUAP5A_391; -.
DR   EnsemblBacteria; BAB13101; BAB13101; BAB13101.
DR   KEGG; buc:BU398; -.
DR   PATRIC; fig|107806.10.peg.412; -.
DR   eggNOG; COG0312; Bacteria.
DR   HOGENOM; CLU_026425_1_0_6; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR   InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR   InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR   InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR   InterPro; IPR025502; TldD.
DR   InterPro; IPR035068; TldD/PmbA_N.
DR   InterPro; IPR036059; TldD/PmbA_sf.
DR   PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR   PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR   Pfam; PF01523; PmbA_TldD_1st; 1.
DR   Pfam; PF19290; PmbA_TldD_2nd; 1.
DR   Pfam; PF19289; PmbA_TldD_3rd; 1.
DR   PIRSF; PIRSF004919; TldD; 1.
DR   SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metalloprotease; Protease; Reference proteome.
FT   CHAIN           1..483
FT                   /note="Metalloprotease TldD homolog"
FT                   /id="PRO_0000142354"
SQ   SEQUENCE   483 AA;  52977 MW;  A05CE98518720EBA CRC64;
     MTFELVTESL LNANKINDQD VFIALEELCT RQLDYGDLYF QSHIHESWIL ENSIIKEGNY
     HSDAGIGVRA IRGESTGFAY SDQISLDSLR RSTKKAHSII LTKGSGKTKT LSKKTIEPIY
     KNVNPLEGFS SKEKTDLLYR ANYIARSLDH RVIEVNASLT GSYEQILVAS TDGNLVSDIR
     PSIQFSISVL VEDHGKRERG RSGGGSRTDY NFFLNQDDSS KEIRIDHWSK EAVRIALLNL
     SSKEALSGTF PVVLGSGWPG VLLHEAIGHG LEGDFNRKGT SIFTNMIGKK VASELCTIID
     DGTIKNQRGS LSIDDEGTPG QKNILIENGI LKKYMQDKLN ARLMGVKSTG NGRRESYSCL
     PMPRMTNTYM LSGKSKLDDI IKSVDYGIYA VNFSGGQVDI TSGKFVFSTS EAYLIKNGKI
     VTPIKNTTLI GSGLEVMQKI SMVGDDLKMD EGMGICGKDG QNIPVGIGQP SMKLENLTIG
     GTV
//