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P57466

- MURA_BUCAI

UniProt

P57466 - MURA_BUCAI

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Protein
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Gene
murA, BU386
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei115 – 1151Proton donor By similarity

GO - Molecular functioni

  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-386-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC:2.5.1.7)
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name:
EPT
Gene namesi
Name:murA
Ordered Locus Names:BU386
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotation
PRO_0000178853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 11512-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Structurei

3D structure databases

ProteinModelPortaliP57466.
SMRiP57466. Positions 1-415.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0766.
HOGENOMiHOG000075602.
KOiK00790.
OMAiHGLEQMG.
OrthoDBiEOG68M4GK.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

P57466-1 [UniParc]FASTAAdd to Basket

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MEKLYVEGNK ILNGHVIISG SKNAALPILF MTILTEGKIK IGNIPNLTDI    50
NIALKLLVYL GVKITGNETL CIDASSINIF CPPYNLINKI RASIWMLGPL 100
LARFGKAKIF LPGGCKIGSR PIDLHLNGLT QLGATINLKN NCIDAYVKGR 150
LQGKYILMEK ISVGATITIM SAATLAKGST IIDNAACEPE IVDIAKFLNT 200
LGADIIGAGS NKICIKGVLK LTGGTHQVIP DRIETGTFLV AAAASQGHIT 250
CHKTEPKHLT NVLMKLTEAG AKIKTGKDWI KLDMRGKRPK SLNICTAPYP 300
GFPTDMQAQF ALLNSISKGI GTITETIFEN RFIYTSELIR MGAKIKIKNN 350
TIICYGIPKL ISSNVFSSDL RASATLILAG CIAAGITIVN HTYHLVRGYE 400
SFPKKLNKIG ANIKII 416
Length:416
Mass (Da):44,869
Last modified:December 1, 2000 - v1
Checksum:i498BA6DBF0723272
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13089.1.
RefSeqiNP_240203.1. NC_002528.1.
WP_010896094.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13089; BAB13089; BAB13089.
GeneIDi1109739.
KEGGibuc:BU386.
PATRICi21244312. VBIBucAph127364_0400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13089.1 .
RefSeqi NP_240203.1. NC_002528.1.
WP_010896094.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57466.
SMRi P57466. Positions 1-415.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13089 ; BAB13089 ; BAB13089 .
GeneIDi 1109739.
KEGGi buc:BU386.
PATRICi 21244312. VBIBucAph127364_0400.

Phylogenomic databases

eggNOGi COG0766.
HOGENOMi HOG000075602.
KOi K00790.
OMAi HGLEQMG.
OrthoDBi EOG68M4GK.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci BAPH107806:GBZJ-386-MONOMER.

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00111. MurA.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view ]
PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01072. murA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiMURA_BUCAI
AccessioniPrimary (citable) accession number: P57466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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