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P57459

- NUSA_BUCAI

UniProt

P57459 - NUSA_BUCAI

Protein

Transcription termination/antitermination protein NusA

Gene

nusA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Participates in both transcription termination and antitermination.UniRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, termination Source: UniProtKB-KW
    2. transcription antitermination Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription antitermination, Transcription regulation, Transcription termination

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-378-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription termination/antitermination protein NusAUniRule annotation
    Gene namesi
    Name:nusAUniRule annotation
    Ordered Locus Names:BU378
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Transcription termination/antitermination protein NusAPRO_0000181962Add
    BLAST

    Proteomic databases

    PRIDEiP57459.

    Interactioni

    Subunit structurei

    Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliP57459.
    SMRiP57459. Positions 430-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini135 – 20066S1 motifUniRule annotationAdd
    BLAST
    Domaini302 – 37069KHUniRule annotationAdd
    BLAST
    Repeati364 – 414511Add
    BLAST
    Repeati440 – 490512Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni364 – 4901272 X 51 AA approximate repeatsUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NusA family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0195.
    HOGENOMiHOG000006394.
    KOiK02600.
    OMAiDVFTKHL.
    OrthoDBiEOG6NSGHW.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.30.1480.10. 1 hit.
    3.30.300.20. 2 hits.
    HAMAPiMF_00945_B. NusA_B.
    InterProiIPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
    IPR004087. KH_dom.
    IPR015946. KH_dom-like_a/b.
    IPR025249. KH_dom_NusA-like.
    IPR004088. KH_dom_type_1.
    IPR009019. KH_prok-type.
    IPR012340. NA-bd_OB-fold.
    IPR028620. NusA.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR022967. RNA-binding_domain_S1.
    IPR013735. TF_NusA_N.
    IPR010214. Tscrpt_termin_fac_NusA_C_rpt.
    IPR010213. Tscrpt_termination_fac_NusA.
    [Graphical view]
    PfamiPF13184. KH_5. 1 hit.
    PF08529. NusA_N. 1 hit.
    PF00575. S1. 1 hit.
    [Graphical view]
    SMARTiSM00322. KH. 2 hits.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47794. SSF47794. 2 hits.
    SSF50249. SSF50249. 1 hit.
    SSF54814. SSF54814. 2 hits.
    SSF69705. SSF69705. 1 hit.
    TIGRFAMsiTIGR01953. NusA. 1 hit.
    TIGR01954. nusA_Cterm_rpt. 2 hits.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57459-1 [UniParc]FASTAAdd to Basket

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    MNKEILAVVE AVSNEKSLPR EKIFEALEMA LATATKKKHE QEIDIRVSIN    50
    RKTGGFTTFR RWMVVETVTQ PTREITLEAA CFDGEKVYLN DYIEEQIESV 100
    DFDRITTQTA KQVIVQKVRE AERAMLVEQF RKYTGQIITG IVKKINRDNI 150
    MLDLGNNAEA LILREGMLPR ENFRPGDRIR GILYGVYPEA RGAQLFISRS 200
    KTEMLTELFR IEVPEIGEEV IEIKAAARDP GSRAKIAVKT NDKRIDPVGA 250
    CVGMRGARVQ AVSSELCGER IDIILWDDNP AQFVINAMAP ADVASIVVDE 300
    DCHTMDIAVD INNLAQAIGR NGQNVRLASQ ISGWELNVMT TEDLHSKHKE 350
    EAHTAFNFFK KNLNINENII KILVKEGFSS LEELAYIPFN ELLEVKNLTE 400
    DQAKKVREGA KSKLLLMESD KNKMIIQERK TEKELLKING MNAVLALQLA 450
    EKNIFTIEEL ADQGIDDLTD IKNLNSEQAG LLIMTARNIC WFSSKV 496
    Length:496
    Mass (Da):55,995
    Last modified:December 1, 2000 - v1
    Checksum:i17878203D5D4164E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13082.1.
    RefSeqiNP_240196.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13082; BAB13082; BAB13082.
    GeneIDi1109732.
    KEGGibuc:BU378.
    PATRICi21244294. VBIBucAph127364_0392.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13082.1 .
    RefSeqi NP_240196.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57459.
    SMRi P57459. Positions 430-494.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P57459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13082 ; BAB13082 ; BAB13082 .
    GeneIDi 1109732.
    KEGGi buc:BU378.
    PATRICi 21244294. VBIBucAph127364_0392.

    Phylogenomic databases

    eggNOGi COG0195.
    HOGENOMi HOG000006394.
    KOi K02600.
    OMAi DVFTKHL.
    OrthoDBi EOG6NSGHW.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-378-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.30.1480.10. 1 hit.
    3.30.300.20. 2 hits.
    HAMAPi MF_00945_B. NusA_B.
    InterProi IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
    IPR004087. KH_dom.
    IPR015946. KH_dom-like_a/b.
    IPR025249. KH_dom_NusA-like.
    IPR004088. KH_dom_type_1.
    IPR009019. KH_prok-type.
    IPR012340. NA-bd_OB-fold.
    IPR028620. NusA.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR022967. RNA-binding_domain_S1.
    IPR013735. TF_NusA_N.
    IPR010214. Tscrpt_termin_fac_NusA_C_rpt.
    IPR010213. Tscrpt_termination_fac_NusA.
    [Graphical view ]
    Pfami PF13184. KH_5. 1 hit.
    PF08529. NusA_N. 1 hit.
    PF00575. S1. 1 hit.
    [Graphical view ]
    SMARTi SM00322. KH. 2 hits.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47794. SSF47794. 2 hits.
    SSF50249. SSF50249. 1 hit.
    SSF54814. SSF54814. 2 hits.
    SSF69705. SSF69705. 1 hit.
    TIGRFAMsi TIGR01953. NusA. 1 hit.
    TIGR01954. nusA_Cterm_rpt. 2 hits.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiNUSA_BUCAI
    AccessioniPrimary (citable) accession number: P57459
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3