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Protein

Transcription termination/antitermination protein NusA

Gene

nusA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Participates in both transcription termination and antitermination.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription antitermination, Transcription regulation, Transcription termination

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination/antitermination protein NusAUniRule annotation
Gene namesi
Name:nusAUniRule annotation
Ordered Locus Names:BU378
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001819621 – 496Transcription termination/antitermination protein NusAAdd BLAST496

Proteomic databases

PRIDEiP57459.

Interactioni

Subunit structurei

Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.UniRule annotation

Protein-protein interaction databases

STRINGi107806.BU378.

Structurei

3D structure databases

ProteinModelPortaliP57459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 200S1 motifUniRule annotationAdd BLAST66
Domaini302 – 370KHUniRule annotationAdd BLAST69
Repeati364 – 4141Add BLAST51
Repeati440 – 4902Add BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni364 – 4902 X 51 AA approximate repeatsUniRule annotationAdd BLAST127

Sequence similaritiesi

Belongs to the NusA family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105CHV. Bacteria.
COG0195. LUCA.
HOGENOMiHOG000006394.
KOiK02600.
OMAiSWKIDIK.

Family and domain databases

Gene3Di3.30.1480.10. 1 hit.
3.30.300.20. 2 hits.
HAMAPiMF_00945_B. NusA_B. 1 hit.
InterProiIPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR015946. KH_dom-like_a/b.
IPR025249. KH_dom_NusA-like.
IPR004088. KH_dom_type_1.
IPR009019. KH_prok-type.
IPR012340. NA-bd_OB-fold.
IPR030842. NusA_bac.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR013735. TF_NusA_N.
IPR010214. Tscrpt_termin_fac_NusA_C_rpt.
IPR010213. Tscrpt_termination_fac_NusA.
[Graphical view]
PfamiPF13184. KH_5. 1 hit.
PF08529. NusA_N. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 2 hits.
SSF50249. SSF50249. 1 hit.
SSF54814. SSF54814. 2 hits.
SSF69705. SSF69705. 1 hit.
TIGRFAMsiTIGR01953. NusA. 1 hit.
TIGR01954. nusA_Cterm_rpt. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKEILAVVE AVSNEKSLPR EKIFEALEMA LATATKKKHE QEIDIRVSIN
60 70 80 90 100
RKTGGFTTFR RWMVVETVTQ PTREITLEAA CFDGEKVYLN DYIEEQIESV
110 120 130 140 150
DFDRITTQTA KQVIVQKVRE AERAMLVEQF RKYTGQIITG IVKKINRDNI
160 170 180 190 200
MLDLGNNAEA LILREGMLPR ENFRPGDRIR GILYGVYPEA RGAQLFISRS
210 220 230 240 250
KTEMLTELFR IEVPEIGEEV IEIKAAARDP GSRAKIAVKT NDKRIDPVGA
260 270 280 290 300
CVGMRGARVQ AVSSELCGER IDIILWDDNP AQFVINAMAP ADVASIVVDE
310 320 330 340 350
DCHTMDIAVD INNLAQAIGR NGQNVRLASQ ISGWELNVMT TEDLHSKHKE
360 370 380 390 400
EAHTAFNFFK KNLNINENII KILVKEGFSS LEELAYIPFN ELLEVKNLTE
410 420 430 440 450
DQAKKVREGA KSKLLLMESD KNKMIIQERK TEKELLKING MNAVLALQLA
460 470 480 490
EKNIFTIEEL ADQGIDDLTD IKNLNSEQAG LLIMTARNIC WFSSKV
Length:496
Mass (Da):55,995
Last modified:December 1, 2000 - v1
Checksum:i17878203D5D4164E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13082.1.
RefSeqiNP_240196.1. NC_002528.1.
WP_009874336.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13082; BAB13082; BAB13082.
GeneIDi1109732.
KEGGibuc:BU378.
PATRICi21244294. VBIBucAph127364_0392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13082.1.
RefSeqiNP_240196.1. NC_002528.1.
WP_009874336.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi107806.BU378.

Proteomic databases

PRIDEiP57459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB13082; BAB13082; BAB13082.
GeneIDi1109732.
KEGGibuc:BU378.
PATRICi21244294. VBIBucAph127364_0392.

Phylogenomic databases

eggNOGiENOG4105CHV. Bacteria.
COG0195. LUCA.
HOGENOMiHOG000006394.
KOiK02600.
OMAiSWKIDIK.

Family and domain databases

Gene3Di3.30.1480.10. 1 hit.
3.30.300.20. 2 hits.
HAMAPiMF_00945_B. NusA_B. 1 hit.
InterProiIPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR015946. KH_dom-like_a/b.
IPR025249. KH_dom_NusA-like.
IPR004088. KH_dom_type_1.
IPR009019. KH_prok-type.
IPR012340. NA-bd_OB-fold.
IPR030842. NusA_bac.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR013735. TF_NusA_N.
IPR010214. Tscrpt_termin_fac_NusA_C_rpt.
IPR010213. Tscrpt_termination_fac_NusA.
[Graphical view]
PfamiPF13184. KH_5. 1 hit.
PF08529. NusA_N. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 2 hits.
SSF50249. SSF50249. 1 hit.
SSF54814. SSF54814. 2 hits.
SSF69705. SSF69705. 1 hit.
TIGRFAMsiTIGR01953. NusA. 1 hit.
TIGR01954. nusA_Cterm_rpt. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUSA_BUCAI
AccessioniPrimary (citable) accession number: P57459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.