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P57453

- DEAD_BUCAI

UniProt

P57453 - DEAD_BUCAI

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Protein

ATP-dependent RNA helicase DeaD

Gene

deaD

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 578ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ATP-dependent RNA helicase activity Source: UniProtKB-HAMAP
  3. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular response to cold Source: InterPro
  2. ribosomal large subunit assembly Source: UniProtKB-HAMAP
  3. RNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-372-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DeaDUniRule annotation (EC:3.6.4.13UniRule annotation)
Alternative name(s):
Cold-shock DEAD box protein AUniRule annotation
Gene namesi
Name:deaDUniRule annotation
Synonyms:csdA
Ordered Locus Names:BU372
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601ATP-dependent RNA helicase DeaDPRO_0000055098Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 208172Helicase ATP-bindingUniRule annotationAdd
BLAST
Domaini231 – 378148Helicase C-terminalUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi6 – 3429Q motifAdd
BLAST
Motifi156 – 1594DEAD box

Sequence similaritiesi

Belongs to the DEAD box helicase family. DeaD subfamily.UniRule annotation
Contains 1 helicase ATP-binding domain.UniRule annotation
Contains 1 helicase C-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0513.
HOGENOMiHOG000268810.
KOiK05592.
OMAiGHACEAL.
OrthoDBiEOG6GBMBM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00964. DEAD_helicase_DeaD.
InterProiIPR005580. DbpA_RNA-bd.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR028618. DEAD_helicase_DeaD.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF03880. DbpA. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57453-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHIESTFSF LGLNPFIIQS LNEMGYVKPS PIQASCIPLL LEGRDVLGMA
60 70 80 90 100
QTGSGKTAAF SLPLLHNLNI NLKAPQILVL APTRELAVQV AEAFSDFSKY
110 120 130 140 150
MIGIHVLPLY GGQRYELQLR ALRQGPQIVV GTPGRLLDHL KRGTLNLSNL
160 170 180 190 200
HGLVLDEADE MLRMGFIEDV ETIMAQIPKE HQTALFSATM PEAIRRISKR
210 220 230 240 250
FMRNPKEIKI QSNITTRPDI KQSYWMVYGR KTDALIRFLE AEDFSATIIF
260 270 280 290 300
VRTKNATLEV SEALERNGYN SAALNGDMNQ ALREQTLERL KNGRLDILIA
310 320 330 340 350
TDVAARGLDV DRISFVINYD IPMDSESYVH RIGRTGRAGR AGRALLFVEN
360 370 380 390 400
RERRLLRNIE RTMKQSIPEV QLPKVELLCQ RRLEQFAKKV QQQLESRDLD
410 420 430 440 450
EYSALLDKLY STDDLDIKTL AAALLKMAQG ERPLIIKPDV IKRQSRDLLF
460 470 480 490 500
QDDRRREDNR NSRTRRDRRD INKDAELYRI EVGRNDGVEV RHIVGAIANE
510 520 530 540 550
GNINSRNIGN IKLFSSYSTI ELPKGMSKDL LQTFNRTRIL NKPINMKLLR
560 570 580 590 600
DSRHYENKTT HRSIFNKDKN SNRRVSDGSF NKSNSPKKTE FKSSFFRRRN

V
Length:601
Mass (Da):68,806
Last modified:December 1, 2000 - v1
Checksum:i886C237AC5E61279
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13076.1.
RefSeqiNP_240190.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13076; BAB13076; BAB13076.
GeneIDi1109726.
KEGGibuc:BU372.
PATRICi21244282. VBIBucAph127364_0386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13076.1 .
RefSeqi NP_240190.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57453.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13076 ; BAB13076 ; BAB13076 .
GeneIDi 1109726.
KEGGi buc:BU372.
PATRICi 21244282. VBIBucAph127364_0386.

Phylogenomic databases

eggNOGi COG0513.
HOGENOMi HOG000268810.
KOi K05592.
OMAi GHACEAL.
OrthoDBi EOG6GBMBM.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-372-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00964. DEAD_helicase_DeaD.
InterProi IPR005580. DbpA_RNA-bd.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR028618. DEAD_helicase_DeaD.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view ]
Pfami PF03880. DbpA. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiDEAD_BUCAI
AccessioniPrimary (citable) accession number: P57453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3