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P57453

- DEAD_BUCAI

UniProt

P57453 - DEAD_BUCAI

Protein

ATP-dependent RNA helicase DeaD

Gene

deaD

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.UniRule annotation

    Catalytic activityi

    ATP + H2O = ADP + phosphate.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi50 – 578ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. ATP-dependent RNA helicase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular response to cold Source: InterPro
    2. ribosomal large subunit assembly Source: UniProtKB-HAMAP
    3. RNA catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-372-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent RNA helicase DeaDUniRule annotation (EC:3.6.4.13UniRule annotation)
    Alternative name(s):
    Cold-shock DEAD box protein AUniRule annotation
    Gene namesi
    Name:deaDUniRule annotation
    Synonyms:csdA
    Ordered Locus Names:BU372
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 601601ATP-dependent RNA helicase DeaDPRO_0000055098Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57453.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 208172Helicase ATP-bindingUniRule annotationAdd
    BLAST
    Domaini231 – 378148Helicase C-terminalUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi6 – 3429Q motifAdd
    BLAST
    Motifi156 – 1594DEAD box

    Sequence similaritiesi

    Belongs to the DEAD box helicase family. DeaD subfamily.UniRule annotation
    Contains 1 helicase ATP-binding domain.UniRule annotation
    Contains 1 helicase C-terminal domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0513.
    HOGENOMiHOG000268810.
    KOiK05592.
    OMAiGHACEAL.
    OrthoDBiEOG6GBMBM.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00964. DEAD_helicase_DeaD.
    InterProiIPR005580. DbpA_RNA-bd.
    IPR028618. DEAD_helicase_DeaD.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view]
    PfamiPF03880. DbpA. 1 hit.
    PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57453-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHIESTFSF LGLNPFIIQS LNEMGYVKPS PIQASCIPLL LEGRDVLGMA    50
    QTGSGKTAAF SLPLLHNLNI NLKAPQILVL APTRELAVQV AEAFSDFSKY 100
    MIGIHVLPLY GGQRYELQLR ALRQGPQIVV GTPGRLLDHL KRGTLNLSNL 150
    HGLVLDEADE MLRMGFIEDV ETIMAQIPKE HQTALFSATM PEAIRRISKR 200
    FMRNPKEIKI QSNITTRPDI KQSYWMVYGR KTDALIRFLE AEDFSATIIF 250
    VRTKNATLEV SEALERNGYN SAALNGDMNQ ALREQTLERL KNGRLDILIA 300
    TDVAARGLDV DRISFVINYD IPMDSESYVH RIGRTGRAGR AGRALLFVEN 350
    RERRLLRNIE RTMKQSIPEV QLPKVELLCQ RRLEQFAKKV QQQLESRDLD 400
    EYSALLDKLY STDDLDIKTL AAALLKMAQG ERPLIIKPDV IKRQSRDLLF 450
    QDDRRREDNR NSRTRRDRRD INKDAELYRI EVGRNDGVEV RHIVGAIANE 500
    GNINSRNIGN IKLFSSYSTI ELPKGMSKDL LQTFNRTRIL NKPINMKLLR 550
    DSRHYENKTT HRSIFNKDKN SNRRVSDGSF NKSNSPKKTE FKSSFFRRRN 600
    V 601
    Length:601
    Mass (Da):68,806
    Last modified:December 1, 2000 - v1
    Checksum:i886C237AC5E61279
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13076.1.
    RefSeqiNP_240190.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13076; BAB13076; BAB13076.
    GeneIDi1109726.
    KEGGibuc:BU372.
    PATRICi21244282. VBIBucAph127364_0386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13076.1 .
    RefSeqi NP_240190.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57453.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13076 ; BAB13076 ; BAB13076 .
    GeneIDi 1109726.
    KEGGi buc:BU372.
    PATRICi 21244282. VBIBucAph127364_0386.

    Phylogenomic databases

    eggNOGi COG0513.
    HOGENOMi HOG000268810.
    KOi K05592.
    OMAi GHACEAL.
    OrthoDBi EOG6GBMBM.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-372-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00964. DEAD_helicase_DeaD.
    InterProi IPR005580. DbpA_RNA-bd.
    IPR028618. DEAD_helicase_DeaD.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view ]
    Pfami PF03880. DbpA. 1 hit.
    PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiDEAD_BUCAI
    AccessioniPrimary (citable) accession number: P57453
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3