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Protein

Aspartate carbamoyltransferase regulatory chain

Gene

pyrI

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in allosteric regulation of aspartate carbamoyltransferase.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi108 – 1081ZincBy similarity
Metal bindingi113 – 1131ZincBy similarity
Metal bindingi138 – 1381ZincBy similarity
Metal bindingi141 – 1411ZincBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. pyrimidine nucleotide biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-370-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferase regulatory chain
Gene namesi
Name:pyrI
Ordered Locus Names:BU370
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. aspartate carbamoyltransferase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Aspartate carbamoyltransferase regulatory chainPRO_0000142298Add
BLAST

Interactioni

Subunit structurei

Contains catalytic and regulatory chains.By similarity

Structurei

3D structure databases

ProteinModelPortaliP57451.
SMRiP57451. Positions 4-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PyrI family.Curated

Phylogenomic databases

eggNOGiCOG1781.
HOGENOMiHOG000113530.
KOiK00610.
OMAiCPNRNCI.
OrthoDBiEOG6JX7QS.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.70.140. 1 hit.
HAMAPiMF_00002. Asp_carb_tr_reg.
InterProiIPR020545. Asp_carbamoyltransf_reg_N.
IPR002801. Asp_carbamoylTrfase_reg.
IPR020542. Asp_carbamoyltrfase_reg_C.
[Graphical view]
PfamiPF01948. PyrI. 1 hit.
PF02748. PyrI_C. 1 hit.
[Graphical view]
ProDomiPD006194. Asp_carbamoylTrfase_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54893. SSF54893. 1 hit.
SSF57825. SSF57825. 1 hit.
TIGRFAMsiTIGR00240. ATCase_reg. 1 hit.

Sequencei

Sequence statusi: Complete.

P57451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEINKLQVEA IKSGSVIDHI PEYIGFKLLS LFRFTETEKR ITIGLNLPSK
60 70 80 90 100
KLGRKDIIKI ENTFLSDEQI NQLAIYAPHA TVNYINEYNL VRKVFPTLPE
110 120 130 140 150
TIDRILICPN SNCVTNHHLI NSSFILKEDQ FFNMNLKCKY CEKEFYKKIV

LSCQ
Length:154
Mass (Da):17,943
Last modified:December 1, 2000 - v1
Checksum:i7F7B31DA11BB974F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13074.1.
RefSeqiNP_240188.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13074; BAB13074; BAB13074.
GeneIDi1109724.
KEGGibuc:BU370.
PATRICi21244278. VBIBucAph127364_0384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13074.1.
RefSeqiNP_240188.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57451.
SMRiP57451. Positions 4-152.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB13074; BAB13074; BAB13074.
GeneIDi1109724.
KEGGibuc:BU370.
PATRICi21244278. VBIBucAph127364_0384.

Phylogenomic databases

eggNOGiCOG1781.
HOGENOMiHOG000113530.
KOiK00610.
OMAiCPNRNCI.
OrthoDBiEOG6JX7QS.

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-370-MONOMER.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.70.140. 1 hit.
HAMAPiMF_00002. Asp_carb_tr_reg.
InterProiIPR020545. Asp_carbamoyltransf_reg_N.
IPR002801. Asp_carbamoylTrfase_reg.
IPR020542. Asp_carbamoyltrfase_reg_C.
[Graphical view]
PfamiPF01948. PyrI. 1 hit.
PF02748. PyrI_C. 1 hit.
[Graphical view]
ProDomiPD006194. Asp_carbamoylTrfase_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54893. SSF54893. 1 hit.
SSF57825. SSF57825. 1 hit.
TIGRFAMsiTIGR00240. ATCase_reg. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiPYRI_BUCAI
AccessioniPrimary (citable) accession number: P57451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.