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Protein

Ornithine carbamoyltransferase

Gene

argI

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argI)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107Carbamoyl phosphateUniRule annotation1
Binding sitei168OrnithineUniRule annotation1
Binding sitei232OrnithineUniRule annotation1
Binding sitei320Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argI
Ordered Locus Names:BU368
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001128971 – 338Ornithine carbamoyltransferaseAdd BLAST338

Proteomic databases

PRIDEiP57449

Interactioni

Protein-protein interaction databases

STRINGi107806.BU368

Structurei

3D structure databases

ProteinModelPortaliP57449
SMRiP57449
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 59Carbamoyl phosphate bindingUniRule annotation4
Regioni134 – 137Carbamoyl phosphate bindingUniRule annotation4
Regioni236 – 237Ornithine bindingUniRule annotation2
Regioni274 – 275Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiENOG4105DBV Bacteria
COG0078 LUCA
HOGENOMiHOG000022686
KOiK00611
OMAiNPFYKRH

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P57449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLYQRDCL RLLDFTSLEL QNIITLAQKL KQYKKNNKEI QLLKKKNIAL
60 70 80 90 100
IFEKESTRTR CSFEVAAFDQ GAHVTYLGPG STHLGTKESI EDTAKILGRL
110 120 130 140 150
YDGIQYRGHH HSTIEILAKN SKVPVWNGLT EKFHPTQLLA DLLTIKEIFP
160 170 180 190 200
ERKFYEIKCA YVGDAHNNMG NSLLEAASLV GLDLRLVAPK ECWPEKNIFK
210 220 230 240 250
FCKEQMKNKK GNIICTENIN EGVKNVDFIY TDVWVSMGES QEVWKKRIEL
260 270 280 290 300
LSSYQVNSLM LKITNNPQVK VLHCLPALHD QKTCTVKSIL KKYGFKNGME
310 320 330
ITDEVFQKNQ KIIFEQAENR LHTIKAILVS SLLKTIKF
Length:338
Mass (Da):38,865
Last modified:December 1, 2000 - v1
Checksum:iE6CCAEE0584668E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA Translation: BAB13072.1
RefSeqiNP_240186.1, NC_002528.1
WP_010896090.1, NC_002528.1

Genome annotation databases

EnsemblBacteriaiBAB13072; BAB13072; BAB13072
GeneIDi1109722
KEGGibuc:BU368
PATRICifig|107806.10.peg.382

Similar proteinsi

Entry informationi

Entry nameiOTC_BUCAI
AccessioniPrimary (citable) accession number: P57449
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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