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P57449

- OTC_BUCAI

UniProt

P57449 - OTC_BUCAI

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Protein
Ornithine carbamoyltransferase
Gene
argI, BU368
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline By similarity.UniRule annotation

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Carbamoyl phosphate By similarity
Sitei31 – 311Important for structural integrity By similarity
Binding sitei72 – 721Carbamoyl phosphate By similarity
Binding sitei107 – 1071Carbamoyl phosphate By similarity
Sitei147 – 1471Important for structural integrity By similarity
Binding sitei168 – 1681Ornithine By similarity
Binding sitei232 – 2321Ornithine By similarity
Binding sitei302 – 3021Carbamoyl phosphate By similarity
Binding sitei320 – 3201Carbamoyl phosphate By similarity

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-368-MONOMER.
UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argI
Ordered Locus Names:BU368
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Ornithine carbamoyltransferaseUniRule annotation
PRO_0000112897Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57449.
SMRiP57449. Positions 3-332.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 605Carbamoyl phosphate binding By similarity
Regioni134 – 1374Carbamoyl phosphate binding By similarity
Regioni236 – 2372Ornithine binding By similarity
Regioni273 – 2764Carbamoyl phosphate binding By similarity

Sequence similaritiesi

Belongs to the ATCase/OTCase family.

Phylogenomic databases

eggNOGiCOG0078.
HOGENOMiHOG000022686.
KOiK00611.
OMAiYQRHFLR.
OrthoDBiEOG690MGV.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57449-1 [UniParc]FASTAAdd to Basket

« Hide

MNNLYQRDCL RLLDFTSLEL QNIITLAQKL KQYKKNNKEI QLLKKKNIAL    50
IFEKESTRTR CSFEVAAFDQ GAHVTYLGPG STHLGTKESI EDTAKILGRL 100
YDGIQYRGHH HSTIEILAKN SKVPVWNGLT EKFHPTQLLA DLLTIKEIFP 150
ERKFYEIKCA YVGDAHNNMG NSLLEAASLV GLDLRLVAPK ECWPEKNIFK 200
FCKEQMKNKK GNIICTENIN EGVKNVDFIY TDVWVSMGES QEVWKKRIEL 250
LSSYQVNSLM LKITNNPQVK VLHCLPALHD QKTCTVKSIL KKYGFKNGME 300
ITDEVFQKNQ KIIFEQAENR LHTIKAILVS SLLKTIKF 338
Length:338
Mass (Da):38,865
Last modified:December 1, 2000 - v1
Checksum:iE6CCAEE0584668E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13072.1.
RefSeqiNP_240186.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13072; BAB13072; BAB13072.
GeneIDi1109722.
KEGGibuc:BU368.
PATRICi21244274. VBIBucAph127364_0382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13072.1 .
RefSeqi NP_240186.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57449.
SMRi P57449. Positions 3-332.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13072 ; BAB13072 ; BAB13072 .
GeneIDi 1109722.
KEGGi buc:BU368.
PATRICi 21244274. VBIBucAph127364_0382.

Phylogenomic databases

eggNOGi COG0078.
HOGENOMi HOG000022686.
KOi K00611.
OMAi YQRHFLR.
OrthoDBi EOG690MGV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00112 .
BioCyci BAPH107806:GBZJ-368-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1370. 2 hits.
HAMAPi MF_01109. OTCase.
InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view ]
Pfami PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view ]
PRINTSi PR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMi SSF53671. SSF53671. 1 hit.
TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiOTC_BUCAI
AccessioniPrimary (citable) accession number: P57449
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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