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P57449

- OTC_BUCAI

UniProt

P57449 - OTC_BUCAI

Protein

Ornithine carbamoyltransferase

Gene

argI

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

    Catalytic activityi

    Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101Carbamoyl phosphateBy similarity
    Sitei31 – 311Important for structural integrityBy similarity
    Binding sitei72 – 721Carbamoyl phosphateBy similarity
    Binding sitei107 – 1071Carbamoyl phosphateBy similarity
    Sitei147 – 1471Important for structural integrityBy similarity
    Binding sitei168 – 1681OrnithineBy similarity
    Binding sitei232 – 2321OrnithineBy similarity
    Binding sitei302 – 3021Carbamoyl phosphateBy similarity
    Binding sitei320 – 3201Carbamoyl phosphateBy similarity

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-368-MONOMER.
    UniPathwayiUPA00068; UER00112.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ornithine carbamoyltransferase (EC:2.1.3.3)
    Short name:
    OTCase
    Gene namesi
    Name:argI
    Ordered Locus Names:BU368
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Ornithine carbamoyltransferasePRO_0000112897Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57449.
    SMRiP57449. Positions 3-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni56 – 605Carbamoyl phosphate bindingBy similarity
    Regioni134 – 1374Carbamoyl phosphate bindingBy similarity
    Regioni236 – 2372Ornithine bindingBy similarity
    Regioni273 – 2764Carbamoyl phosphate bindingBy similarity

    Sequence similaritiesi

    Belongs to the ATCase/OTCase family.Curated

    Phylogenomic databases

    eggNOGiCOG0078.
    HOGENOMiHOG000022686.
    KOiK00611.
    OMAiYQRHFLR.
    OrthoDBiEOG690MGV.

    Family and domain databases

    Gene3Di3.40.50.1370. 2 hits.
    HAMAPiMF_01109. OTCase.
    InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view]
    PfamiPF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view]
    PRINTSiPR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMiSSF53671. SSF53671. 1 hit.
    TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
    PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57449-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNLYQRDCL RLLDFTSLEL QNIITLAQKL KQYKKNNKEI QLLKKKNIAL    50
    IFEKESTRTR CSFEVAAFDQ GAHVTYLGPG STHLGTKESI EDTAKILGRL 100
    YDGIQYRGHH HSTIEILAKN SKVPVWNGLT EKFHPTQLLA DLLTIKEIFP 150
    ERKFYEIKCA YVGDAHNNMG NSLLEAASLV GLDLRLVAPK ECWPEKNIFK 200
    FCKEQMKNKK GNIICTENIN EGVKNVDFIY TDVWVSMGES QEVWKKRIEL 250
    LSSYQVNSLM LKITNNPQVK VLHCLPALHD QKTCTVKSIL KKYGFKNGME 300
    ITDEVFQKNQ KIIFEQAENR LHTIKAILVS SLLKTIKF 338
    Length:338
    Mass (Da):38,865
    Last modified:December 1, 2000 - v1
    Checksum:iE6CCAEE0584668E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13072.1.
    RefSeqiNP_240186.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13072; BAB13072; BAB13072.
    GeneIDi1109722.
    KEGGibuc:BU368.
    PATRICi21244274. VBIBucAph127364_0382.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13072.1 .
    RefSeqi NP_240186.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57449.
    SMRi P57449. Positions 3-332.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13072 ; BAB13072 ; BAB13072 .
    GeneIDi 1109722.
    KEGGi buc:BU368.
    PATRICi 21244274. VBIBucAph127364_0382.

    Phylogenomic databases

    eggNOGi COG0078.
    HOGENOMi HOG000022686.
    KOi K00611.
    OMAi YQRHFLR.
    OrthoDBi EOG690MGV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00112 .
    BioCyci BAPH107806:GBZJ-368-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1370. 2 hits.
    HAMAPi MF_01109. OTCase.
    InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view ]
    Pfami PF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMi SSF53671. SSF53671. 1 hit.
    TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
    PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiOTC_BUCAI
    AccessioniPrimary (citable) accession number: P57449
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3