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P57437

- PTGCB_BUCAI

UniProt

P57437 - PTGCB_BUCAI

Protein

PTS system glucose-specific EIICB component

Gene

ptsG

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport By similarity.By similarity

    Catalytic activityi

    Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei421 – 4211Phosphocysteine intermediate; for EIIB activityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. glucose transmembrane transporter activity Source: InterPro
    2. kinase activity Source: UniProtKB-KW
    3. protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Phosphotransferase system, Sugar transport, Transport

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-356-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PTS system glucose-specific EIICB component
    Alternative name(s):
    EIICB-Glc
    Short name:
    EII-Glc
    Including the following 2 domains:
    Glucose permease IIC component
    Alternative name(s):
    PTS system glucose-specific EIIC component
    Glucose-specific phosphotransferase enzyme IIB component (EC:2.7.1.69)
    Alternative name(s):
    PTS system glucose-specific EIIB component
    Gene namesi
    Name:ptsG
    Ordered Locus Names:BU356
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    Cell membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477PTS system glucose-specific EIICB componentPRO_0000186525Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57437.
    SMRiP57437. Positions 401-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei51 – 7121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei76 – 9621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei112 – 13221HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei152 – 17221HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei191 – 21121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei250 – 27021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei280 – 30021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei304 – 32421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei357 – 37721HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 388388PTS EIIC type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini399 – 47779PTS EIIB type-1PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
    The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.

    Sequence similaritiesi

    Contains 1 PTS EIIB type-1 domain.PROSITE-ProRule annotation
    Contains 1 PTS EIIC type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1263.
    HOGENOMiHOG000250993.
    KOiK02778.
    K02779.
    OMAiMQIGEFT.
    OrthoDBiEOG6FFS9V.

    Family and domain databases

    Gene3Di3.30.1360.60. 1 hit.
    InterProiIPR018113. PTrfase_EIIB_Cys.
    IPR003352. PTS_EIIC.
    IPR013013. PTS_EIIC_1.
    IPR001996. PTS_IIB_1.
    IPR011299. PTS_IIBC_glc.
    [Graphical view]
    PfamiPF00367. PTS_EIIB. 1 hit.
    PF02378. PTS_EIIC. 1 hit.
    [Graphical view]
    SUPFAMiSSF55604. SSF55604. 1 hit.
    TIGRFAMsiTIGR00826. EIIB_glc. 1 hit.
    TIGR02002. PTS-II-BC-glcB. 1 hit.
    PROSITEiPS51098. PTS_EIIB_TYPE_1. 1 hit.
    PS01035. PTS_EIIB_TYPE_1_CYS. 1 hit.
    PS51103. PTS_EIIC_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57437-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKNVFANLQ KVGKSLMLPV SVLPIAGILL GIGSAHFNFL PDILSQIMAQ    50
    TGGSVFSNMP LIFAIGVALG FTNNDGVAAL AAVVSYGILI QTLTAVEPIV 100
    LHTTIEVIKN KHLSDTGILG GIIAGAISAY MFNKFYRIQL PEYLGFFAGK 150
    RFVPIISGLS AILIGVILSL IWPPIGHGIQ IFSKWAAYQN PILAFALYGL 200
    VERALVPFGL HHIWNVPFQM QIGEYTNSIG QVFHGDIARY MAGDSTAGNL 250
    SGGFIFKMYG LPGAALAIWH TSKKENKTKI GSIMISAALT AFLTGITEPI 300
    EFSFIIVAPV LYVIHAILAG LSFPLCIFLD MRAGTSFSHG FIDFIVLSGN 350
    SHHILLFPII GILYGLLYYI LFYLFIINFN LDTPGRENIK NNILEKDNNE 400
    IAPYIITALG GKNNIKNLDA CITRLRITVS DISKVKQKDL KNIGAAGIII 450
    SGSGIQVVFG TRSENIKTAM DECIKNI 477
    Length:477
    Mass (Da):51,727
    Last modified:December 1, 2000 - v1
    Checksum:i5204C68E94477C5F
    GO

    Sequence cautioni

    The sequence BAB13060.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13060.1. Different initiation.
    RefSeqiNP_240174.2. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13060; BAB13060; BAB13060.
    GeneIDi1110052.
    KEGGibuc:BU356.
    PATRICi21244248. VBIBucAph127364_0369.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13060.1 . Different initiation.
    RefSeqi NP_240174.2. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57437.
    SMRi P57437. Positions 401-476.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13060 ; BAB13060 ; BAB13060 .
    GeneIDi 1110052.
    KEGGi buc:BU356.
    PATRICi 21244248. VBIBucAph127364_0369.

    Phylogenomic databases

    eggNOGi COG1263.
    HOGENOMi HOG000250993.
    KOi K02778.
    K02779.
    OMAi MQIGEFT.
    OrthoDBi EOG6FFS9V.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-356-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.60. 1 hit.
    InterProi IPR018113. PTrfase_EIIB_Cys.
    IPR003352. PTS_EIIC.
    IPR013013. PTS_EIIC_1.
    IPR001996. PTS_IIB_1.
    IPR011299. PTS_IIBC_glc.
    [Graphical view ]
    Pfami PF00367. PTS_EIIB. 1 hit.
    PF02378. PTS_EIIC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55604. SSF55604. 1 hit.
    TIGRFAMsi TIGR00826. EIIB_glc. 1 hit.
    TIGR02002. PTS-II-BC-glcB. 1 hit.
    PROSITEi PS51098. PTS_EIIB_TYPE_1. 1 hit.
    PS01035. PTS_EIIB_TYPE_1_CYS. 1 hit.
    PS51103. PTS_EIIC_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiPTGCB_BUCAI
    AccessioniPrimary (citable) accession number: P57437
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3