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P57434

- KTHY_BUCAI

UniProt

P57434 - KTHY_BUCAI

Protein

Thymidylate kinase

Gene

tmk

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.By similarity

    Catalytic activityi

    ATP + dTMP = ADP + dTDP.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTDP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-353-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate kinase (EC:2.7.4.9)
    Alternative name(s):
    dTMP kinase
    Gene namesi
    Name:tmk
    Ordered Locus Names:BU353
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Thymidylate kinasePRO_0000155249Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0125.
    HOGENOMiHOG000229078.
    KOiK00943.
    OMAiEPGGCPI.
    OrthoDBiEOG64JFSH.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00165. Thymidylate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
    PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57434-1 [UniParc]FASTAAdd to Basket

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    MIKSKFIVIE GLEGAGKTNA CICIKNLLKK NSIKNVLLVR QPGSTPIAED    50
    IRRLIKKKFN DDNLIKETEL LLMYAARIQL VEKKIKPALK NGIWVISDRH 100
    DLSSLAYQGG GLGIPKKIIY QLQSLFLNNF IPDLTIYLDV SPEIGLARAL 150
    KRNPLDLIES RSLFFFKKTR RCYLEKSKLD KKTIIINANL NIKKVTQNIT 200
    KKMLNWLNKQ VI 212
    Length:212
    Mass (Da):24,247
    Last modified:December 1, 2000 - v1
    Checksum:iC999F8C1A404348B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13057.1.
    RefSeqiNP_240171.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13057; BAB13057; BAB13057.
    GeneIDi1110049.
    KEGGibuc:BU353.
    PATRICi21244242. VBIBucAph127364_0366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13057.1 .
    RefSeqi NP_240171.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57434.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13057 ; BAB13057 ; BAB13057 .
    GeneIDi 1110049.
    KEGGi buc:BU353.
    PATRICi 21244242. VBIBucAph127364_0366.

    Phylogenomic databases

    eggNOGi COG0125.
    HOGENOMi HOG000229078.
    KOi K00943.
    OMAi EPGGCPI.
    OrthoDBi EOG64JFSH.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-353-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00165. Thymidylate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
    PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiKTHY_BUCAI
    AccessioniPrimary (citable) accession number: P57434
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3