P57434 (KTHY_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	BU353

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Acyrthosiphon pisum)

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Thymidylate kinase HAMAP-Rule MF_00165		PRO_0000155249
Regions
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P57434 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: C999F8C1A404348B	FASTA	212	24,247
	10 20 30 40 50 60 MIKSKFIVIE GLEGAGKTNA CICIKNLLKK NSIKNVLLVR QPGSTPIAED IRRLIKKKFN 70 80 90 100 110 120 DDNLIKETEL LLMYAARIQL VEKKIKPALK NGIWVISDRH DLSSLAYQGG GLGIPKKIIY 130 140 150 160 170 180 QLQSLFLNNF IPDLTIYLDV SPEIGLARAL KRNPLDLIES RSLFFFKKTR RCYLEKSKLD 190 200 210 KKTIIINANL NIKKVTQNIT KKMLNWLNKQ VI

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB13057.1.
RefSeq	NP_240171.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57434.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB13057; BAB13057; BAB13057.
GeneID	1110049.
KEGG	buc:BU353.
PATRIC	21244242. VBIBucAph127364_0366.
Phylogenomic databases
eggNOG	COG0125.
HOGENOM	HOG000229078.
KO	K00943.
OMA	ITLEGPE.
ProtClustDB	PRK00698.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase.
InterPro	IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
PANTHER	PTHR10344. PTHR10344. 1 hit.
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_BUCAI

Accession

Primary (citable) accession number: P57434

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program