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P57430

- RLUC_BUCAI

UniProt

P57430 - RLUC_BUCAI

Protein

Ribosomal large subunit pseudouridine synthase C

Gene

rluC

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.By similarity

    Catalytic activityi

    23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei143 – 1431By similarity

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro
    2. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-348-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal large subunit pseudouridine synthase C (EC:5.4.99.24)
    Alternative name(s):
    23S rRNA pseudouridine(955/2504/2580) synthase
    rRNA pseudouridylate synthase C
    rRNA-uridine isomerase C
    Gene namesi
    Name:rluC
    Ordered Locus Names:BU348
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Ribosomal large subunit pseudouridine synthase CPRO_0000162664Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57430.
    SMRiP57430. Positions 92-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 8465S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase RluA family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0564.
    HOGENOMiHOG000275914.
    KOiK06179.
    OMAiKKQVNAP.
    OrthoDBiEOG6P070X.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR006225. PsdUridine_synth_RluC/D.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PfamiPF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
    PROSITEiPS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57430-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHKILPISI IYINKEMLNQ RIDNFMRSKF KSVPKSMIYR IIRTGKIRIN    50
    KKRIKPHYKL KIGDILKIPP IKILCDIKNT FFPLNHSTNL LNRILYEDSH 100
    LLIINKPSGI AVHGGSGLNF GVIEYFRKLR PLNKFLELVH RIDRDTSGVL 150
    ILAKKRTSLV SLHEQLREKK IKKEYIALVH GLWPDHIKKI SEPLLKIQFK 200
    NKQKMVLIDK KGKPSETYFQ IKKKFSSSTL LSIIPKTGRT HQIRVHALHA 250
    GHPIFFDKRY GKNDLDADIK NNHKINRLLL HSSGVHFIHP KNGNKIYIKA 300
    PLDIDFQNYL NTII 314
    Length:314
    Mass (Da):36,614
    Last modified:December 1, 2000 - v1
    Checksum:i4B0FC4D2FD085B08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13053.1.
    RefSeqiNP_240167.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13053; BAB13053; BAB13053.
    GeneIDi1110044.
    KEGGibuc:BU348.
    PATRICi21244230. VBIBucAph127364_0360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13053.1 .
    RefSeqi NP_240167.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57430.
    SMRi P57430. Positions 92-312.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13053 ; BAB13053 ; BAB13053 .
    GeneIDi 1110044.
    KEGGi buc:BU348.
    PATRICi 21244230. VBIBucAph127364_0360.

    Phylogenomic databases

    eggNOGi COG0564.
    HOGENOMi HOG000275914.
    KOi K06179.
    OMAi KKQVNAP.
    OrthoDBi EOG6P070X.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-348-MONOMER.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR006225. PsdUridine_synth_RluC/D.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    Pfami PF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    TIGRFAMsi TIGR00005. rluA_subfam. 1 hit.
    PROSITEi PS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiRLUC_BUCAI
    AccessioniPrimary (citable) accession number: P57430
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3