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P57430

- RLUC_BUCAI

UniProt

P57430 - RLUC_BUCAI

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Protein

Ribosomal large subunit pseudouridine synthase C

Gene

rluC

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.By similarity

Catalytic activityi

23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei143 – 1431By similarity

GO - Molecular functioni

  1. pseudouridine synthase activity Source: InterPro
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
  2. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-348-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal large subunit pseudouridine synthase C (EC:5.4.99.24)
Alternative name(s):
23S rRNA pseudouridine(955/2504/2580) synthase
rRNA pseudouridylate synthase C
rRNA-uridine isomerase C
Gene namesi
Name:rluC
Ordered Locus Names:BU348
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Ribosomal large subunit pseudouridine synthase CPRO_0000162664Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57430.
SMRiP57430. Positions 92-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 8465S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0564.
HOGENOMiHOG000275914.
KOiK06179.
OMAiKKQVNAP.
OrthoDBiEOG6P070X.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57430-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHKILPISI IYINKEMLNQ RIDNFMRSKF KSVPKSMIYR IIRTGKIRIN
60 70 80 90 100
KKRIKPHYKL KIGDILKIPP IKILCDIKNT FFPLNHSTNL LNRILYEDSH
110 120 130 140 150
LLIINKPSGI AVHGGSGLNF GVIEYFRKLR PLNKFLELVH RIDRDTSGVL
160 170 180 190 200
ILAKKRTSLV SLHEQLREKK IKKEYIALVH GLWPDHIKKI SEPLLKIQFK
210 220 230 240 250
NKQKMVLIDK KGKPSETYFQ IKKKFSSSTL LSIIPKTGRT HQIRVHALHA
260 270 280 290 300
GHPIFFDKRY GKNDLDADIK NNHKINRLLL HSSGVHFIHP KNGNKIYIKA
310
PLDIDFQNYL NTII
Length:314
Mass (Da):36,614
Last modified:December 1, 2000 - v1
Checksum:i4B0FC4D2FD085B08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13053.1.
RefSeqiNP_240167.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13053; BAB13053; BAB13053.
GeneIDi1110044.
KEGGibuc:BU348.
PATRICi21244230. VBIBucAph127364_0360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13053.1 .
RefSeqi NP_240167.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57430.
SMRi P57430. Positions 92-312.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13053 ; BAB13053 ; BAB13053 .
GeneIDi 1110044.
KEGGi buc:BU348.
PATRICi 21244230. VBIBucAph127364_0360.

Phylogenomic databases

eggNOGi COG0564.
HOGENOMi HOG000275914.
KOi K06179.
OMAi KKQVNAP.
OrthoDBi EOG6P070X.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-348-MONOMER.

Family and domain databases

Gene3Di 3.10.290.10. 1 hit.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view ]
Pfami PF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
SUPFAMi SSF55120. SSF55120. 1 hit.
TIGRFAMsi TIGR00005. rluA_subfam. 1 hit.
PROSITEi PS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiRLUC_BUCAI
AccessioniPrimary (citable) accession number: P57430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3