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P57430 (RLUC_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosomal large subunit pseudouridine synthase C

EC=5.4.99.24
Alternative name(s):
23S rRNA pseudouridine(955/2504/2580) synthase
rRNA pseudouridylate synthase C
rRNA-uridine isomerase C
Gene names
Name:rluC
Ordered Locus Names:BU348
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA By similarity.

Catalytic activity

23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

Sequence similarities

Belongs to the pseudouridine synthase RluA family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   Biological processrRNA processing
   LigandRNA-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

rRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Ribosomal large subunit pseudouridine synthase C
PRO_0000162664

Regions

Domain20 – 8465S4 RNA-binding

Sites

Active site1431 By similarity

Sequences

Sequence LengthMass (Da)Tools
P57430 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 4B0FC4D2FD085B08

FASTA31436,614
        10         20         30         40         50         60 
MTHKILPISI IYINKEMLNQ RIDNFMRSKF KSVPKSMIYR IIRTGKIRIN KKRIKPHYKL 

        70         80         90        100        110        120 
KIGDILKIPP IKILCDIKNT FFPLNHSTNL LNRILYEDSH LLIINKPSGI AVHGGSGLNF 

       130        140        150        160        170        180 
GVIEYFRKLR PLNKFLELVH RIDRDTSGVL ILAKKRTSLV SLHEQLREKK IKKEYIALVH 

       190        200        210        220        230        240 
GLWPDHIKKI SEPLLKIQFK NKQKMVLIDK KGKPSETYFQ IKKKFSSSTL LSIIPKTGRT 

       250        260        270        280        290        300 
HQIRVHALHA GHPIFFDKRY GKNDLDADIK NNHKINRLLL HSSGVHFIHP KNGNKIYIKA 

       310 
PLDIDFQNYL NTII 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB13053.1.
RefSeqNP_240167.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57430.
SMRP57430. Positions 92-312.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB13053; BAB13053; BAB13053.
GeneID1110044.
KEGGbuc:BU348.
PATRIC21244230. VBIBucAph127364_0360.

Phylogenomic databases

eggNOGCOG0564.
HOGENOMHOG000275914.
KOK06179.
OMAIVRVPPV.
OrthoDBEOG6P070X.
ProtClustDBCLSK316749.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-348-MONOMER.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTSM00363. S4. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00005. rluA_subfam. 1 hit.
PROSITEPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLUC_BUCAI
AccessionPrimary (citable) accession number: P57430
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 13, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names