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Protein

Probable lipid II flippase MurJ

Gene

murJ

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Biological processi

Keywordsi

Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis, Transport

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lipid II flippase MurJUniRule annotation
Gene namesi
Name:murJUniRule annotation
Synonyms:mviN
Ordered Locus Names:BU333
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Transmembranei133 – 153HelicalUniRule annotationAdd BLAST21
Transmembranei156 – 178HelicalUniRule annotationAdd BLAST23
Transmembranei245 – 265HelicalUniRule annotationAdd BLAST21
Transmembranei271 – 291HelicalUniRule annotationAdd BLAST21
Transmembranei315 – 335HelicalUniRule annotationAdd BLAST21
Transmembranei356 – 376HelicalUniRule annotationAdd BLAST21
Transmembranei400 – 420HelicalUniRule annotationAdd BLAST21
Transmembranei442 – 462HelicalUniRule annotationAdd BLAST21
Transmembranei481 – 501HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001820001 – 511Probable lipid II flippase MurJAdd BLAST511

Proteomic databases

PRIDEiP57415.

Interactioni

Protein-protein interaction databases

STRINGi107806.BU333.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurJ/MviN family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJR. Bacteria.
COG0728. LUCA.
HOGENOMiHOG000263812.
KOiK03980.
OMAiIFFVAFK.

Family and domain databases

CDDicd13123. MATE_MurJ_like. 1 hit.
HAMAPiMF_02078. MurJ_MviN. 1 hit.
InterProiView protein in InterPro
IPR004268. MurJ.
PfamiView protein in Pfam
PF03023. MVIN. 1 hit.
PIRSFiPIRSF002869. MviN. 1 hit.
PRINTSiPR01806. VIRFACTRMVIN.
TIGRFAMsiTIGR01695. murJ_mviN. 1 hit.

Sequencei

Sequence statusi: Complete.

P57415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLKPLISV SLMTLISRIL GFVRDILIAS IFGASMFTDA FFISFKIPNL
60 70 80 90 100
LRRIFSDGTF SQAFIPVLME YKSDKNEKNI KNFLSSILGF MSFFLLLLTI
110 120 130 140 150
LGGFFSQSII LIRAPGFLNP PEKLILSTNL LRIMFPYILL ISLSSLCSSI
160 170 180 190 200
LNSWNYFSIP AFSPIFLNIS IIFFSVFFSS FFCPSIIVLA WSVIIGGLVQ
210 220 230 240 250
LLYQLPFLYK INMLVLPNFH WNNIGLLRIL KKMGPAILGA SANQISLIIN
260 270 280 290 300
TIFSSLLNSG SISWIYYADR LIEFPVGILG VSLSTVLFTS LAKNYKNGIK
310 320 330 340 350
LEYKKLLDWG LRISLIVSLP GSVILFFLAK PVIIVLFQYG KFTDFDVLMT
360 370 380 390 400
ARVLKLYSCG LISFIFVKIL SSAFYACEEI KIPMKASLFT LLLNQLMNPF
410 420 430 440 450
LIFYFQHAGI ALSLSITSWV NFLLLSRKLY QRKIVSLQRS EFIFIIYIIL
460 470 480 490 500
ATLVMIVILF VVLHMMSVWN IGTFINKIIR LFFGKYVSGI TYLFMMNILG
510
IRLLNFFYKN S
Length:511
Mass (Da):58,192
Last modified:December 1, 2000 - v1
Checksum:iD95FF4B563410A9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13038.1.
RefSeqiNP_240152.1. NC_002528.1.
WP_010896072.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13038; BAB13038; BAB13038.
GeneIDi1110029.
KEGGibuc:BU333.
PATRICifig|107806.10.peg.343.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMURJ_BUCAI
AccessioniPrimary (citable) accession number: P57415
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: June 7, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families