P57413 (RSMC_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase C
EC=2.1.1.172

Alternative name(s):
16S rRNA m2G1207 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RsmC

Gene names

Name:	rsmC
Ordered Locus Names:	BU328

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Acyrthosiphon pisum)

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle By similarity. HAMAP-Rule MF_01862
Catalytic activity	S-adenosyl-L-methionine + guanine(1207) in 16S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1207) in 16S rRNA. HAMAP-Rule MF_01862
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_01862.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmC family.
Sequence caution	The sequence BAB13036.1 differs from that shown. Reason: Frameshift at position 57.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	16S rRNA (guanine(1207)-N(2))-methyltransferase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Ribosomal RNA small subunit methyltransferase C HAMAP-Rule MF_01862		PRO_0000097487

Sequences

	Sequence		Length	Mass (Da)
	P57413 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: E43516DDD22FA014	FASTA	338	39,105
	10 20 30 40 50 60 MLLSKNSQLI LRHRKKFKTK KVFFSGNIQD DFPLSLSTMR TKINFHKYND CIDFKKKIMN 70 80 90 100 110 120 NNIVHNNLLI SQEMIQNCDV IIYYWPKDKS EAKFQLMNII SCSPINTEIF IVGNNSSGVK 130 140 150 160 170 180 SAPLMLKKWI ELEKIDSAKH SILISGLIKK KAIFVLEDFF KTHLWKNLII KSLPGVFGHK 190 200 210 220 230 240 KIDSGSKLLA STFSNRITGK VLDIGCGTGF LSASLLYFSP DAILTLVDNN MYALKCSQYT 250 260 270 280 290 300 LNSNKFNGKI VYSNLYSNVF KKFDLIISNP PFHNDLQINF NIIEKMICGA KKYLTKTGEL 310 320 330 RFVTSRFINC HFLLNKFFQK YYVIKETSQY KVYQAFYK

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB13036.1. Frameshift.
RefSeq	NP_240150.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57413.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB13036; BAB13036; BAB13036.
GeneID	1110027.
KEGG	buc:BU328.
PATRIC	21244186. VBIBucAph127364_0341.
Phylogenomic databases
eggNOG	COG2813.
HOGENOM	HOG000218308.
KO	K00564.
OMA	RHCQLWQ.
ProtClustDB	CLSK315665.
Family and domain databases
HAMAP	MF_01862. 16SrRNA_methyltr_C.
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR013675. Mtase_sm_N. IPR023543. rRNA_ssu_MeTfrase_C. IPR007848. Small_mtfrase_dom. [Graphical view]
Pfam	PF05175. MTS. 1 hit. PF08468. MTS_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSMC_BUCAI

Accession

Primary (citable) accession number: P57413

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program