P57405 (G6PD_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate 1-dehydrogenase
Short name=G6PD
EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	BU320

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068112
Sites
	Active site	238	1	Proton acceptor By similarity
	Binding site	17	1	NADP By similarity
	Binding site	49	1	NADP By similarity
	Binding site	176	1	Substrate By similarity
	Binding site	180	1	Substrate By similarity
	Binding site	343	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57405 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 3DFAE2D26EB690F2	FASTA	491	57,218
	10 20 30 40 50 60 MIIETNHACD LVIFGAKGDL TKRKLLPALY KLEKSKKIHK YTRIIASGRA DWSTEDYIEK 70 80 90 100 110 120 IKTEVKNFLN EEINDLIWKN LSSRIFFCNI DVHEPLHFFR LKTILKQKKN IIVYYCAVPS 130 140 150 160 170 180 NTLNSIFIGL GNAHLNSVPS RIVLEKPLGV CLKTSKKIND QISKYFLESQ IFRIDHYLGK 190 200 210 220 230 240 ESILNLFALR FSNTCLFYNW NNKTIDHIQI TVSEEVGIED RWNYFNMMGQ MKDMVQNHLL 250 260 270 280 290 300 QILTILTMDQ PKNISSESIQ HEKVKILRSL NPINIHNINK KTVRGQYCSG VINEKKVPSY 310 320 330 340 350 360 LEENGANKNS LTETFVAIKV DLNNKQWSGV PFYLRTGKRL AHKYSEIVVF FKKKPTNLFK 370 380 390 400 410 420 NLNSELLQNK LIIRLEPNPN IIFDFSVKAP GLEQEYKIEN SQLKSSQFSK KYSKNSIDAY 430 440 450 460 470 480 ERLLFEIMRG VQSLFVCRDE IEAAWKWIDP IIHAWKNSKN NAPQLYMSGT WGPKNSDLLL 490 AHDGRVWYEF H

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB13028.1.
RefSeq	NP_240142.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57405.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000003242; EBBUCP00000003018; EBBUCG00000003242.
GeneID	1110019.
GenomeReviews	Gene locus BU320 in contig BA000003_GR.
KEGG	buc:BU320.
PATRIC	21244168. VBIBucAph127364_0332.
Phylogenomic databases
GeneTree	EBGT00050000008153.
HOGENOM	HBG322449.
OMA	DFSAYAD.
PhylomeDB	P57405.
ProtClustDB	PRK05722.
Enzyme and pathway databases
BioCyc	BSP107806:BU320-MONOMER.
Family and domain databases
InterPro	IPR001282. G6P_DH. IPR019796. G6P_DH_AS. IPR022675. G6P_DH_C. IPR022674. G6P_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00036.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. Zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_BUCAI

Accession

Primary (citable) accession number: P57405

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program