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P57405

- G6PD_BUCAI

UniProt

P57405 - G6PD_BUCAI

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491NADPUniRule annotation
Binding sitei146 – 1461NADPUniRule annotation
Binding sitei176 – 1761SubstrateUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation
Binding sitei214 – 2141SubstrateUniRule annotation
Binding sitei233 – 2331SubstrateUniRule annotation
Active sitei238 – 2381Proton acceptorUniRule annotation
Binding sitei338 – 3381SubstrateUniRule annotation
Binding sitei343 – 3431SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi91 – 922NADPUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-320-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:BU320
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Glucose-6-phosphate 1-dehydrogenasePRO_0000068112Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiDSIMEAW.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57405-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIETNHACD LVIFGAKGDL TKRKLLPALY KLEKSKKIHK YTRIIASGRA
60 70 80 90 100
DWSTEDYIEK IKTEVKNFLN EEINDLIWKN LSSRIFFCNI DVHEPLHFFR
110 120 130 140 150
LKTILKQKKN IIVYYCAVPS NTLNSIFIGL GNAHLNSVPS RIVLEKPLGV
160 170 180 190 200
CLKTSKKIND QISKYFLESQ IFRIDHYLGK ESILNLFALR FSNTCLFYNW
210 220 230 240 250
NNKTIDHIQI TVSEEVGIED RWNYFNMMGQ MKDMVQNHLL QILTILTMDQ
260 270 280 290 300
PKNISSESIQ HEKVKILRSL NPINIHNINK KTVRGQYCSG VINEKKVPSY
310 320 330 340 350
LEENGANKNS LTETFVAIKV DLNNKQWSGV PFYLRTGKRL AHKYSEIVVF
360 370 380 390 400
FKKKPTNLFK NLNSELLQNK LIIRLEPNPN IIFDFSVKAP GLEQEYKIEN
410 420 430 440 450
SQLKSSQFSK KYSKNSIDAY ERLLFEIMRG VQSLFVCRDE IEAAWKWIDP
460 470 480 490
IIHAWKNSKN NAPQLYMSGT WGPKNSDLLL AHDGRVWYEF H
Length:491
Mass (Da):57,218
Last modified:December 1, 2000 - v1
Checksum:i3DFAE2D26EB690F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13028.1.
RefSeqiNP_240142.1. NC_002528.1.
WP_010896065.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13028; BAB13028; BAB13028.
GeneIDi1110019.
KEGGibuc:BU320.
PATRICi21244168. VBIBucAph127364_0332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13028.1 .
RefSeqi NP_240142.1. NC_002528.1.
WP_010896065.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57405.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13028 ; BAB13028 ; BAB13028 .
GeneIDi 1110019.
KEGGi buc:BU320.
PATRICi 21244168. VBIBucAph127364_0332.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi DSIMEAW.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci BAPH107806:GBZJ-320-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiG6PD_BUCAI
AccessioniPrimary (citable) accession number: P57405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 1, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3