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P57405

- G6PD_BUCAI

UniProt

P57405 - G6PD_BUCAI

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
zwf, BU320
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491NADP By similarity
Binding sitei146 – 1461NADP By similarity
Binding sitei176 – 1761Substrate By similarity
Binding sitei180 – 1801Substrate By similarity
Binding sitei214 – 2141Substrate By similarity
Binding sitei233 – 2331Substrate By similarity
Active sitei238 – 2381Proton acceptor By similarity
Binding sitei338 – 3381Substrate By similarity
Binding sitei343 – 3431Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi91 – 922NADP By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-320-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:BU320
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Glucose-6-phosphate 1-dehydrogenaseUniRule annotationPRO_0000068112Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57405.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiDSIMEAW.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57405-1 [UniParc]FASTAAdd to Basket

« Hide

MIIETNHACD LVIFGAKGDL TKRKLLPALY KLEKSKKIHK YTRIIASGRA    50
DWSTEDYIEK IKTEVKNFLN EEINDLIWKN LSSRIFFCNI DVHEPLHFFR 100
LKTILKQKKN IIVYYCAVPS NTLNSIFIGL GNAHLNSVPS RIVLEKPLGV 150
CLKTSKKIND QISKYFLESQ IFRIDHYLGK ESILNLFALR FSNTCLFYNW 200
NNKTIDHIQI TVSEEVGIED RWNYFNMMGQ MKDMVQNHLL QILTILTMDQ 250
PKNISSESIQ HEKVKILRSL NPINIHNINK KTVRGQYCSG VINEKKVPSY 300
LEENGANKNS LTETFVAIKV DLNNKQWSGV PFYLRTGKRL AHKYSEIVVF 350
FKKKPTNLFK NLNSELLQNK LIIRLEPNPN IIFDFSVKAP GLEQEYKIEN 400
SQLKSSQFSK KYSKNSIDAY ERLLFEIMRG VQSLFVCRDE IEAAWKWIDP 450
IIHAWKNSKN NAPQLYMSGT WGPKNSDLLL AHDGRVWYEF H 491
Length:491
Mass (Da):57,218
Last modified:December 1, 2000 - v1
Checksum:i3DFAE2D26EB690F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13028.1.
RefSeqiNP_240142.1. NC_002528.1.
WP_010896065.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13028; BAB13028; BAB13028.
GeneIDi1110019.
KEGGibuc:BU320.
PATRICi21244168. VBIBucAph127364_0332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13028.1 .
RefSeqi NP_240142.1. NC_002528.1.
WP_010896065.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57405.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13028 ; BAB13028 ; BAB13028 .
GeneIDi 1110019.
KEGGi buc:BU320.
PATRICi 21244168. VBIBucAph127364_0332.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi DSIMEAW.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci BAPH107806:GBZJ-320-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiG6PD_BUCAI
AccessioniPrimary (citable) accession number: P57405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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