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P57404 (KPYK_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Enzyme regulation

Allosterically activated by AMP and by several sugar phosphates. Belongs to type II PK By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Pyruvate kinase
PRO_0000112058

Sites

Metal binding381Potassium By similarity
Metal binding401Potassium By similarity
Metal binding701Potassium By similarity
Metal binding2251Magnesium By similarity
Metal binding2521Magnesium By similarity
Binding site361Substrate By similarity
Binding site2511Substrate; via amide nitrogen By similarity
Binding site2521Substrate; via amide nitrogen By similarity
Binding site2841Substrate By similarity
Site2231Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P57404 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 5C955A1A2C561969

FASTA48052,691
        10         20         30         40         50         60 
MLNRLRRTKI VATLGPSTDI NNNLEKIIRS GVNVLRFNFS HGSKDEHKSR ANQAREIMTR 

        70         80         90        100        110        120 
LNFHIALLGD LQGPKIRISK FIKNNIFLNV GDFFILDANL DQNNGNQERV GIDYKQLPYD 

       130        140        150        160        170        180 
LKVGDVLLLD DGRIQLKVIK STGHEILTKV VIGGILSNNK GINKLGGGLS ADALTEKDKK 

       190        200        210        220        230        240 
DIILATEINV DYLAISFPRC SNDLKQARKL AKEFGSNAKI IAKIERAEAV LNQNTIEDII 

       250        260        270        280        290        300 
LASDAIMIAR GDLGVEIGDS ELAGIQKKLI RTARQLNRIV ITATQMMESM ITNPLPTRAE 

       310        320        330        340        350        360 
VMDVANAVLD GSDAVMLSAE TASGEYPAET VIKMAKICKG AEKVPSINVS RHRIHAKFDD 

       370        380        390        400        410        420 
IEEAIAMSAM YVANHLKGIT AIITMTESGK TALMTSRITS GLPIFALSKN KETLNLASLY 

       430        440        450        460        470        480 
RGVTPIYFNS KNNNFKAANE AIVLLRKRGF LCRGELVIIT QGDIMGKIGK TNTSRILKVV 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB13027.1.
RefSeqNP_240141.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57404.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB13027; BAB13027; BAB13027.
GeneID1110018.
KEGGbuc:BU319.
PATRIC21244166. VBIBucAph127364_0331.

Phylogenomic databases

eggNOGCOG0469.
HOGENOMHOG000021558.
KOK00873.
OMATPVYFDS.
OrthoDBEOG6GBMB0.
ProtClustDBCLSK315882.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-319-MONOMER.
UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_BUCAI
AccessionPrimary (citable) accession number: P57404
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 13, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names