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P57392

- GLPF_BUCAI

UniProt

P57392 - GLPF_BUCAI

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Protein

Glycerol uptake facilitator protein

Gene

glpF

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity).By similarity

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. glycerol metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Glycerol metabolism, Transport

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol uptake facilitator protein
Gene namesi
Name:glpF
Ordered Locus Names:BU306
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Glycerol uptake facilitator proteinPRO_0000064078Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57392.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicBy similarity
Topological domaini37 – 415ExtracellularBy similarity
Topological domaini63 – 653CytoplasmicBy similarity
Topological domaini81 – 866CytoplasmicBy similarity
Topological domaini111 – 14535ExtracellularBy similarityAdd
BLAST
Topological domaini172 – 18110CytoplasmicBy similarity
Topological domaini199 – 2024ExtracellularBy similarity
Topological domaini221 – 23616ExtracellularBy similarityAdd
BLAST
Topological domaini260 – 2634CytoplasmicBy similarity

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei66 – 694By similarity
Intramembranei70 – 8011Helical; Name=M3By similarityAdd
BLAST
Intramembranei203 – 2064By similarity
Intramembranei207 – 22014Helical; Name=M7By similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 3629Helical; Name=M1By similarityAdd
BLAST
Transmembranei42 – 6221Helical; Name=M2By similarityAdd
BLAST
Transmembranei87 – 11024Helical; Name=M4By similarityAdd
BLAST
Transmembranei146 – 17126Helical; Name=M5By similarityAdd
BLAST
Transmembranei182 – 19817Helical; Name=M6By similarityAdd
BLAST
Transmembranei237 – 25923Helical; Name=M8By similarityAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi70 – 723NPA 1
Motifi207 – 2093NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
HOGENOMiHOG000288287.
KOiK02440.
OMAiCFDGRKV.
OrthoDBiEOG6TXQWK.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57392 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNIYRKKNII KKCFMEFFGT GLVMFFGIGC LAASKLTNAN FTQFEISCIW
60 70 80 90 100
GFGVSIAIYF SSSISGAHLN PAVTIFFWLS SKLNKRKVLP YIISQTLGSF
110 120 130 140 150
FFTMLTYYLY NNLLISFERN NNVVRGTQES LNLASIFCVY PNYNNSFIYD
160 170 180 190 200
FIIEIFSTAL FILIVLEFNN RNSNYFLYNR SVAPILTGFL VCMINLVINP
210 220 230 240 250
LNNISLNPAR DLGPKILLSL TGWGLFSFTG GNDNILYCFI PIMGPILGAN
260
LGGWIHKTLI NNS
Length:263
Mass (Da):29,720
Last modified:December 1, 2000 - v1
Checksum:i7F28F094BB56201B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13015.1.
RefSeqiNP_240129.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13015; BAB13015; BAB13015.
GeneIDi1110005.
KEGGibuc:BU306.
PATRICi21244138. VBIBucAph127364_0317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13015.1 .
RefSeqi NP_240129.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57392.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13015 ; BAB13015 ; BAB13015 .
GeneIDi 1110005.
KEGGi buc:BU306.
PATRICi 21244138. VBIBucAph127364_0317.

Phylogenomic databases

eggNOGi COG0580.
HOGENOMi HOG000288287.
KOi K02440.
OMAi CFDGRKV.
OrthoDBi EOG6TXQWK.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-306-MONOMER.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
InterProi IPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view ]
PANTHERi PTHR19139. PTHR19139. 1 hit.
Pfami PF00230. MIP. 1 hit.
[Graphical view ]
PRINTSi PR00783. MINTRINSICP.
SUPFAMi SSF81338. SSF81338. 1 hit.
PROSITEi PS00221. MIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiGLPF_BUCAI
AccessioniPrimary (citable) accession number: P57392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3