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P57392

- GLPF_BUCAI

UniProt

P57392 - GLPF_BUCAI

Protein

Glycerol uptake facilitator protein

Gene

glpF

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane By similarity.By similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. glycerol metabolic process Source: UniProtKB-KW

    Keywords - Biological processi

    Glycerol metabolism, Transport

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-306-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol uptake facilitator protein
    Gene namesi
    Name:glpF
    Ordered Locus Names:BU306
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Glycerol uptake facilitator proteinPRO_0000064078Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57392.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicBy similarity
    Topological domaini37 – 415ExtracellularBy similarity
    Topological domaini63 – 653CytoplasmicBy similarity
    Topological domaini81 – 866CytoplasmicBy similarity
    Topological domaini111 – 14535ExtracellularBy similarityAdd
    BLAST
    Topological domaini172 – 18110CytoplasmicBy similarity
    Topological domaini199 – 2024ExtracellularBy similarity
    Topological domaini221 – 23616ExtracellularBy similarityAdd
    BLAST
    Topological domaini260 – 2634CytoplasmicBy similarity

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei66 – 694By similarity
    Intramembranei70 – 8011Helical; Name=M3By similarityAdd
    BLAST
    Intramembranei203 – 2064By similarity
    Intramembranei207 – 22014Helical; Name=M7By similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 3629Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei42 – 6221Helical; Name=M2By similarityAdd
    BLAST
    Transmembranei87 – 11024Helical; Name=M4By similarityAdd
    BLAST
    Transmembranei146 – 17126Helical; Name=M5By similarityAdd
    BLAST
    Transmembranei182 – 19817Helical; Name=M6By similarityAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=M8By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi70 – 723NPA 1
    Motifi207 – 2093NPA 2

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0580.
    HOGENOMiHOG000288287.
    KOiK02440.
    OMAiCFDGRKV.
    OrthoDBiEOG6TXQWK.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view]
    PANTHERiPTHR19139. PTHR19139. 1 hit.
    PfamiPF00230. MIP. 1 hit.
    [Graphical view]
    PRINTSiPR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.
    PROSITEiPS00221. MIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57392-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIYRKKNII KKCFMEFFGT GLVMFFGIGC LAASKLTNAN FTQFEISCIW    50
    GFGVSIAIYF SSSISGAHLN PAVTIFFWLS SKLNKRKVLP YIISQTLGSF 100
    FFTMLTYYLY NNLLISFERN NNVVRGTQES LNLASIFCVY PNYNNSFIYD 150
    FIIEIFSTAL FILIVLEFNN RNSNYFLYNR SVAPILTGFL VCMINLVINP 200
    LNNISLNPAR DLGPKILLSL TGWGLFSFTG GNDNILYCFI PIMGPILGAN 250
    LGGWIHKTLI NNS 263
    Length:263
    Mass (Da):29,720
    Last modified:December 1, 2000 - v1
    Checksum:i7F28F094BB56201B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13015.1.
    RefSeqiNP_240129.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13015; BAB13015; BAB13015.
    GeneIDi1110005.
    KEGGibuc:BU306.
    PATRICi21244138. VBIBucAph127364_0317.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13015.1 .
    RefSeqi NP_240129.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57392.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13015 ; BAB13015 ; BAB13015 .
    GeneIDi 1110005.
    KEGGi buc:BU306.
    PATRICi 21244138. VBIBucAph127364_0317.

    Phylogenomic databases

    eggNOGi COG0580.
    HOGENOMi HOG000288287.
    KOi K02440.
    OMAi CFDGRKV.
    OrthoDBi EOG6TXQWK.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-306-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view ]
    PANTHERi PTHR19139. PTHR19139. 1 hit.
    Pfami PF00230. MIP. 1 hit.
    [Graphical view ]
    PRINTSi PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    PROSITEi PS00221. MIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiGLPF_BUCAI
    AccessioniPrimary (citable) accession number: P57392
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3