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Protein

Glycerol uptake facilitator protein

Gene

glpF

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Glycerol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol uptake facilitator protein
Gene namesi
Name:glpF
Ordered Locus Names:BU306
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicBy similarity7
Transmembranei8 – 36Helical; Name=M1By similarityAdd BLAST29
Topological domaini37 – 41ExtracellularBy similarity5
Transmembranei42 – 62Helical; Name=M2By similarityAdd BLAST21
Topological domaini63 – 65CytoplasmicBy similarity3
Intramembranei66 – 69By similarity4
Intramembranei70 – 80Helical; Name=M3By similarityAdd BLAST11
Topological domaini81 – 86CytoplasmicBy similarity6
Transmembranei87 – 110Helical; Name=M4By similarityAdd BLAST24
Topological domaini111 – 145ExtracellularBy similarityAdd BLAST35
Transmembranei146 – 171Helical; Name=M5By similarityAdd BLAST26
Topological domaini172 – 181CytoplasmicBy similarity10
Transmembranei182 – 198Helical; Name=M6By similarityAdd BLAST17
Topological domaini199 – 202ExtracellularBy similarity4
Intramembranei203 – 206By similarity4
Intramembranei207 – 220Helical; Name=M7By similarityAdd BLAST14
Topological domaini221 – 236ExtracellularBy similarityAdd BLAST16
Transmembranei237 – 259Helical; Name=M8By similarityAdd BLAST23
Topological domaini260 – 263CytoplasmicBy similarity4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640781 – 263Glycerol uptake facilitator proteinAdd BLAST263

Interactioni

Protein-protein interaction databases

STRINGi107806.BU306.

Structurei

3D structure databases

ProteinModelPortaliP57392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi70 – 72NPA 13
Motifi207 – 209NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D8C. Bacteria.
COG0580. LUCA.
HOGENOMiHOG000288287.
KOiK02440.
OMAiAREIPYF.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIYRKKNII KKCFMEFFGT GLVMFFGIGC LAASKLTNAN FTQFEISCIW
60 70 80 90 100
GFGVSIAIYF SSSISGAHLN PAVTIFFWLS SKLNKRKVLP YIISQTLGSF
110 120 130 140 150
FFTMLTYYLY NNLLISFERN NNVVRGTQES LNLASIFCVY PNYNNSFIYD
160 170 180 190 200
FIIEIFSTAL FILIVLEFNN RNSNYFLYNR SVAPILTGFL VCMINLVINP
210 220 230 240 250
LNNISLNPAR DLGPKILLSL TGWGLFSFTG GNDNILYCFI PIMGPILGAN
260
LGGWIHKTLI NNS
Length:263
Mass (Da):29,720
Last modified:December 1, 2000 - v1
Checksum:i7F28F094BB56201B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13015.1.
RefSeqiNP_240129.1. NC_002528.1.
WP_010896060.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13015; BAB13015; BAB13015.
GeneIDi1110005.
KEGGibuc:BU306.
PATRICi21244138. VBIBucAph127364_0317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13015.1.
RefSeqiNP_240129.1. NC_002528.1.
WP_010896060.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi107806.BU306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB13015; BAB13015; BAB13015.
GeneIDi1110005.
KEGGibuc:BU306.
PATRICi21244138. VBIBucAph127364_0317.

Phylogenomic databases

eggNOGiENOG4105D8C. Bacteria.
COG0580. LUCA.
HOGENOMiHOG000288287.
KOiK02440.
OMAiAREIPYF.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPF_BUCAI
AccessioniPrimary (citable) accession number: P57392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.