Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P57388 (ODO1_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:sucA
Ordered Locus Names:BU302
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length909 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9099092-oxoglutarate dehydrogenase E1 component
PRO_0000162187

Sequences

Sequence LengthMass (Da)Tools
P57388 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: AE739F8CD9F9CF8B

FASTA909105,807
        10         20         30         40         50         60 
MDKNKIEYWL NSSWLSRENQ NYIETIYKSF LTNAQSIDDM WHKAFLEFSE EQKNTYERNN 

        70         80         90        100        110        120 
TKNNKYLLIK KIDHMIHAFR SEGYQQSLID PLKLKKRTKI HDLDLSFYNF TEEETRQTVE 

       130        140        150        160        170        180 
INFKNCTNFR TNIISLYKIL YKKYCGSIGF EYMYVNNLLE KQWITNHIES FFNENVFTIE 

       190        200        210        220        230        240 
EKINFLKELT YAETLEKYIG KKFPGAKRFS LEGAETLIPV LHEVIRFSKK NNISKIVLGM 

       250        260        270        280        290        300 
AHRGRLNVLI NVLNKSPKVL FDEFSNLNLF QKISGDVKYH MGGTAEIQYE KKIIFHMACN 

       310        320        330        340        350        360 
PSHLEIINPV VSGISRSYID NMKNIDNEVL PISIHGDASV IGQGVVQETL NMSQTEGYKV 

       370        380        390        400        410        420 
GGTVHIIINN QIGFTTSNPK HLRSSEYCTD VAKIIQAPVF HVNADDLEAS IFAIQLALHF 

       430        440        450        460        470        480 
RKIFKKDVFI DLVCYRRNGH NEVDEPSVTQ PIMYQKIKNH PTSRTIYSDV LISKKIITSE 

       490        500        510        520        530        540 
KNQEIMNQYL SKLQKGHYIF SKSKNIHFKN EFFLEEKKIK KIKKDVNFSD LKNLACLINQ 

       550        560        570        580        590        600 
IPDSVKMHQR VKKIYEERLE MAQRLKLFDW GAAETLAYAT ILNEGISCRI SGEDVSRGTF 

       610        620        630        640        650        660 
FHRHAFIHNQ INGSIYIPLN NISKKQGKFQ IWDSVLSEEA VLAFEYGYSL SSPNTLTIWE 

       670        680        690        700        710        720 
AQFGDFINGA QIVIDQFISS GEQKWNKKSN LVVLLPHGYE GQGPEHSSSR IERFLQLCAE 

       730        740        750        760        770        780 
ENMQICIPTT SSQIFHIFRK QIFDKILKPL IIFTPKSLLR NPMASSSFDD LVYGKFQKIL 

       790        800        810        820        830        840 
DEVDNVNKKE IRLIFCSGKI YYDLLRNRRE KKINSIILIR IEQLYPFPEG EILKILKNYF 

       850        860        870        880        890        900 
YIKDFIWCQE EPYNQGAWFY IKDCLSNILP LDASLKYIGR SSSASPAVGY ISIHKKQQEK 


IIYNALNIN 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB13011.1.
RefSeqNP_240125.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57388.
SMRP57388. Positions 71-909.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB13011; BAB13011; BAB13011.
GeneID1110001.
KEGGbuc:BU302.
PATRIC21244130. VBIBucAph127364_0313.

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMANEGVANE.
OrthoDBEOG6V1M1F.
ProtClustDBPRK09404.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-302-MONOMER.

Family and domain databases

InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_BUCAI
AccessionPrimary (citable) accession number: P57388
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 13, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names