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P57388

- ODO1_BUCAI

UniProt

P57388 - ODO1_BUCAI

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-302-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:sucA
    Ordered Locus Names:BU302
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9099092-oxoglutarate dehydrogenase E1 componentPRO_0000162187Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP57388.
    SMRiP57388. Positions 71-909.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259588.
    KOiK00164.
    OMAiGHQNANL.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P57388-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKNKIEYWL NSSWLSRENQ NYIETIYKSF LTNAQSIDDM WHKAFLEFSE    50
    EQKNTYERNN TKNNKYLLIK KIDHMIHAFR SEGYQQSLID PLKLKKRTKI 100
    HDLDLSFYNF TEEETRQTVE INFKNCTNFR TNIISLYKIL YKKYCGSIGF 150
    EYMYVNNLLE KQWITNHIES FFNENVFTIE EKINFLKELT YAETLEKYIG 200
    KKFPGAKRFS LEGAETLIPV LHEVIRFSKK NNISKIVLGM AHRGRLNVLI 250
    NVLNKSPKVL FDEFSNLNLF QKISGDVKYH MGGTAEIQYE KKIIFHMACN 300
    PSHLEIINPV VSGISRSYID NMKNIDNEVL PISIHGDASV IGQGVVQETL 350
    NMSQTEGYKV GGTVHIIINN QIGFTTSNPK HLRSSEYCTD VAKIIQAPVF 400
    HVNADDLEAS IFAIQLALHF RKIFKKDVFI DLVCYRRNGH NEVDEPSVTQ 450
    PIMYQKIKNH PTSRTIYSDV LISKKIITSE KNQEIMNQYL SKLQKGHYIF 500
    SKSKNIHFKN EFFLEEKKIK KIKKDVNFSD LKNLACLINQ IPDSVKMHQR 550
    VKKIYEERLE MAQRLKLFDW GAAETLAYAT ILNEGISCRI SGEDVSRGTF 600
    FHRHAFIHNQ INGSIYIPLN NISKKQGKFQ IWDSVLSEEA VLAFEYGYSL 650
    SSPNTLTIWE AQFGDFINGA QIVIDQFISS GEQKWNKKSN LVVLLPHGYE 700
    GQGPEHSSSR IERFLQLCAE ENMQICIPTT SSQIFHIFRK QIFDKILKPL 750
    IIFTPKSLLR NPMASSSFDD LVYGKFQKIL DEVDNVNKKE IRLIFCSGKI 800
    YYDLLRNRRE KKINSIILIR IEQLYPFPEG EILKILKNYF YIKDFIWCQE 850
    EPYNQGAWFY IKDCLSNILP LDASLKYIGR SSSASPAVGY ISIHKKQQEK 900
    IIYNALNIN 909
    Length:909
    Mass (Da):105,807
    Last modified:December 1, 2000 - v1
    Checksum:iAE739F8CD9F9CF8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13011.1.
    RefSeqiNP_240125.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB13011; BAB13011; BAB13011.
    GeneIDi1110001.
    KEGGibuc:BU302.
    PATRICi21244130. VBIBucAph127364_0313.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB13011.1 .
    RefSeqi NP_240125.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57388.
    SMRi P57388. Positions 71-909.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB13011 ; BAB13011 ; BAB13011 .
    GeneIDi 1110001.
    KEGGi buc:BU302.
    PATRICi 21244130. VBIBucAph127364_0313.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259588.
    KOi K00164.
    OMAi GHQNANL.
    OrthoDBi EOG6V1M1F.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-302-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiODO1_BUCAI
    AccessioniPrimary (citable) accession number: P57388
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3