Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P57388

- ODO1_BUCAI

UniProt

P57388 - ODO1_BUCAI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.By similarity

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-302-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:BU302
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9099092-oxoglutarate dehydrogenase E1 componentPRO_0000162187Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP57388.
SMRiP57388. Positions 71-909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

P57388-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKNKIEYWL NSSWLSRENQ NYIETIYKSF LTNAQSIDDM WHKAFLEFSE
60 70 80 90 100
EQKNTYERNN TKNNKYLLIK KIDHMIHAFR SEGYQQSLID PLKLKKRTKI
110 120 130 140 150
HDLDLSFYNF TEEETRQTVE INFKNCTNFR TNIISLYKIL YKKYCGSIGF
160 170 180 190 200
EYMYVNNLLE KQWITNHIES FFNENVFTIE EKINFLKELT YAETLEKYIG
210 220 230 240 250
KKFPGAKRFS LEGAETLIPV LHEVIRFSKK NNISKIVLGM AHRGRLNVLI
260 270 280 290 300
NVLNKSPKVL FDEFSNLNLF QKISGDVKYH MGGTAEIQYE KKIIFHMACN
310 320 330 340 350
PSHLEIINPV VSGISRSYID NMKNIDNEVL PISIHGDASV IGQGVVQETL
360 370 380 390 400
NMSQTEGYKV GGTVHIIINN QIGFTTSNPK HLRSSEYCTD VAKIIQAPVF
410 420 430 440 450
HVNADDLEAS IFAIQLALHF RKIFKKDVFI DLVCYRRNGH NEVDEPSVTQ
460 470 480 490 500
PIMYQKIKNH PTSRTIYSDV LISKKIITSE KNQEIMNQYL SKLQKGHYIF
510 520 530 540 550
SKSKNIHFKN EFFLEEKKIK KIKKDVNFSD LKNLACLINQ IPDSVKMHQR
560 570 580 590 600
VKKIYEERLE MAQRLKLFDW GAAETLAYAT ILNEGISCRI SGEDVSRGTF
610 620 630 640 650
FHRHAFIHNQ INGSIYIPLN NISKKQGKFQ IWDSVLSEEA VLAFEYGYSL
660 670 680 690 700
SSPNTLTIWE AQFGDFINGA QIVIDQFISS GEQKWNKKSN LVVLLPHGYE
710 720 730 740 750
GQGPEHSSSR IERFLQLCAE ENMQICIPTT SSQIFHIFRK QIFDKILKPL
760 770 780 790 800
IIFTPKSLLR NPMASSSFDD LVYGKFQKIL DEVDNVNKKE IRLIFCSGKI
810 820 830 840 850
YYDLLRNRRE KKINSIILIR IEQLYPFPEG EILKILKNYF YIKDFIWCQE
860 870 880 890 900
EPYNQGAWFY IKDCLSNILP LDASLKYIGR SSSASPAVGY ISIHKKQQEK

IIYNALNIN
Length:909
Mass (Da):105,807
Last modified:December 1, 2000 - v1
Checksum:iAE739F8CD9F9CF8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13011.1.
RefSeqiNP_240125.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13011; BAB13011; BAB13011.
GeneIDi1110001.
KEGGibuc:BU302.
PATRICi21244130. VBIBucAph127364_0313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB13011.1 .
RefSeqi NP_240125.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57388.
SMRi P57388. Positions 71-909.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB13011 ; BAB13011 ; BAB13011 .
GeneIDi 1110001.
KEGGi buc:BU302.
PATRICi 21244130. VBIBucAph127364_0313.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-302-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiODO1_BUCAI
AccessioniPrimary (citable) accession number: P57388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3