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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE), Anthranilate synthase component 1 (trpE), Anthranilate synthase component 2 (trpG)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Tryptophan biosynthesis protein TrpCF (trpC)
  4. Tryptophan biosynthesis protein TrpCF (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Anthranilate 1; via carbonyl oxygenUniRule annotation
Binding sitei79 – 791Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei87 – 871PhosphoribosylpyrophosphateUniRule annotation
Metal bindingi91 – 911Magnesium 1UniRule annotation
Binding sitei110 – 1101Anthranilate 1UniRule annotation
Binding sitei119 – 1191Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei165 – 1651Anthranilate 2UniRule annotation
Metal bindingi223 – 2231Magnesium 2UniRule annotation
Metal bindingi224 – 2241Magnesium 1UniRule annotation
Metal bindingi224 – 2241Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-280-MONOMER.
UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:BU280
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Anthranilate phosphoribosyltransferasePRO_0000154434Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi107806.BU280.

Structurei

3D structure databases

ProteinModelPortaliP57367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 832Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni89 – 924Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni107 – 1159Phosphoribosylpyrophosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiHSGQAYQ.
OrthoDBiEOG6D5G6B.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
HAMAPiMF_00211. TrpD.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

P57367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNILLKIYD SKFLNQEESY QLFTLISSGK ITDIKLASIL TAMKIRGESI
60 70 80 90 100
EEITGAIKAF LDKMKYFPKP DYIFSDIVGT GGDAKNTINI STMSAFVAAT
110 120 130 140 150
CGLKIIKHCN QRISSKSGSS DILEKFNINL NASPEKSRKT LDQLNICFLF
160 170 180 190 200
APKYHDGFKY SNNVRTDLKT KTIFNFLGPF LNPATPPLSV IGVYNKNLIN
210 220 230 240 250
IAVNILKNLQ YKRAIVLHSD NTDEVTLYGT TYVSELLNKK IISYQLQPES
260 270 280 290 300
FGLKMHPKKI LKINSLEENY HIIKEIMKGK GSKLYEELIA VNVAMLLKVF
310 320 330 340
GYENLKENTK LALNKIRSGD VYKHIRNVAN MLKEDNHARH NT
Length:342
Mass (Da):38,756
Last modified:December 1, 2000 - v1
Checksum:i9258AE148596CC24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12990.1.
RefSeqiNP_240104.1. NC_002528.1.
WP_009874234.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12990; BAB12990; BAB12990.
GeneIDi1109719.
KEGGibuc:BU280.
PATRICi21244084. VBIBucAph127364_0290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12990.1.
RefSeqiNP_240104.1. NC_002528.1.
WP_009874234.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi107806.BU280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB12990; BAB12990; BAB12990.
GeneIDi1109719.
KEGGibuc:BU280.
PATRICi21244084. VBIBucAph127364_0290.

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiHSGQAYQ.
OrthoDBiEOG6D5G6B.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.
BioCyciBAPH107806:GBZJ-280-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
HAMAPiMF_00211. TrpD.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiTRPD_BUCAI
AccessioniPrimary (citable) accession number: P57367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 11, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.