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P57366

- TRPC_BUCAI

UniProt

P57366 - TRPC_BUCAI

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Protein
Tryptophan biosynthesis protein TrpCF
Gene
trpC, trpC/F, BU279
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain By similarity.UniRule annotation

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-279-MONOMER.
UniPathwayiUPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TrpCF
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
Synonyms:trpC/F
Ordered Locus Names:BU279
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Tryptophan biosynthesis protein TrpCFUniRule annotation
PRO_0000154271Add
BLAST

Proteomic databases

PRIDEiP57366.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP57366.
SMRiP57366. Positions 4-260.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 257257Indole-3-glycerol phosphate synthaseUniRule annotation
Add
BLAST
Regioni258 – 453196N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.
In the C-terminal section; belongs to the TrpF family.

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000280458.
KOiK13498.
OMAiEKYFQGD.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57366-1 [UniParc]FASTAAdd to Basket

« Hide

MQDTTLKKII QDKSEWIRLR KEKQPLIDFK DKINKKTRDF YHSLKEKKPC    50
FILEYKKKSP SLGIIRNNFN LIEISNVYKK YASSVSVLTD EKYFHGNLNF 100
INIVRECVSQ PVLCKDFFID PYQVYLSRYY NADAILLMLS VLNDIQYKEL 150
SIIAKKLNMG ILTEVNNIEE LKRALKLNAN IIGINNRNLH DLSIDLNRTR 200
TLSSLIKKDT IIISESGIKK YREIKELSKF VNGFLIGSHL MSQTNLETAV 250
RSIIFGDNKV CGLTRSIDIE VSEKYGAIYG GLIFVKNSPR YITKKTAKNI 300
SINRKLKLIG IFQNENINII VDIAEELSLY GVQLHGQENK QYIDKLRNIL 350
PKKINIWKAF SIQSELPDRN WDNVNMYIFD SDSGGSNTSF NWSILNHHIL 400
DNVILAGGIN LKNCITASKL KCSGLDLNSG VEISPGIKDY KKIKSIFQKL 450
RYG 453
Length:453
Mass (Da):52,065
Last modified:December 1, 2000 - v1
Checksum:i25F506D52614D9E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12989.1.
RefSeqiNP_240103.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12989; BAB12989; BAB12989.
GeneIDi1109718.
KEGGibuc:BU279.
PATRICi21244082. VBIBucAph127364_0289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12989.1 .
RefSeqi NP_240103.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57366.
SMRi P57366. Positions 4-260.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P57366.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12989 ; BAB12989 ; BAB12989 .
GeneIDi 1109718.
KEGGi buc:BU279.
PATRICi 21244082. VBIBucAph127364_0289.

Phylogenomic databases

eggNOGi COG0134.
HOGENOMi HOG000280458.
KOi K13498.
OMAi EKYFQGD.
OrthoDBi EOG6WT8JX.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
UPA00035 ; UER00043 .
BioCyci BAPH107806:GBZJ-279-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
HAMAPi MF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiTRPC_BUCAI
AccessioniPrimary (citable) accession number: P57366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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