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P57365

- TRPA_BUCAI

UniProt

P57365 - TRPA_BUCAI

Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton acceptorUniRule annotation
    Active sitei60 – 601Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-277-MONOMER.
    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
    Gene namesi
    Name:trpAUniRule annotation
    Ordered Locus Names:BU277
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Tryptophan synthase alpha chainPRO_0000098754Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliP57365.
    SMRiP57365. Positions 2-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0159.
    HOGENOMiHOG000223814.
    KOiK01695.
    OMAiANPIEAM.
    OrthoDBiEOG6RVG0K.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00131. Trp_synth_alpha.
    InterProiIPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view]
    PfamiPF00290. Trp_syntA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00262. trpA. 1 hit.
    PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57365-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRYQETFKR LSCLKEGCFI PFVVLGDPSL ETSIKIIETL IKSGADALEI    50
    GIPFSDPLAD GPTVQKSNLR ALSKNNTFFE YFKILKQLRK KNKKLPIGIL 100
    IYANLVYNQG IDNFYFQCFN SGLDSVLIAD VPIEESKIFY NIANKYKINP 150
    IFICPPDADA DFLYKISLYA QGFIYVLSRP GVTGIKNNTI ALPRDFINKI 200
    KKYNSVPLLQ GFGISNPKQI KEAISSGLSG VICGSAIINI IEKYLNQEKK 250
    MIKEIKKFTH LLKLSTKLE 269
    Length:269
    Mass (Da):30,323
    Last modified:December 1, 2000 - v1
    Checksum:iB1A59668F09BF3A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12987.1.
    RefSeqiNP_240101.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12987; BAB12987; BAB12987.
    GeneIDi1109716.
    KEGGibuc:BU277.
    PATRICi21244078. VBIBucAph127364_0287.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12987.1 .
    RefSeqi NP_240101.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57365.
    SMRi P57365. Positions 2-267.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12987 ; BAB12987 ; BAB12987 .
    GeneIDi 1109716.
    KEGGi buc:BU277.
    PATRICi 21244078. VBIBucAph127364_0287.

    Phylogenomic databases

    eggNOGi COG0159.
    HOGENOMi HOG000223814.
    KOi K01695.
    OMAi ANPIEAM.
    OrthoDBi EOG6RVG0K.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .
    BioCyci BAPH107806:GBZJ-277-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00131. Trp_synth_alpha.
    InterProi IPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view ]
    Pfami PF00290. Trp_syntA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00262. trpA. 1 hit.
    PROSITEi PS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiTRPA_BUCAI
    AccessioniPrimary (citable) accession number: P57365
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3