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P57365

- TRPA_BUCAI

UniProt

P57365 - TRPA_BUCAI

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Protein

Tryptophan synthase alpha chain

Gene
trpA, BU277
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton acceptor By similarity
Active sitei60 – 601Proton acceptor By similarity

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-277-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chain (EC:4.2.1.20)
Gene namesi
Name:trpA
Ordered Locus Names:BU277
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Tryptophan synthase alpha chainUniRule annotationPRO_0000098754Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains By similarity.

Structurei

3D structure databases

ProteinModelPortaliP57365.
SMRiP57365. Positions 2-267.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.

Phylogenomic databases

eggNOGiCOG0159.
HOGENOMiHOG000223814.
KOiK01695.
OMAiANPIEAM.
OrthoDBiEOG6RVG0K.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamiPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57365-1 [UniParc]FASTAAdd to Basket

« Hide

MNRYQETFKR LSCLKEGCFI PFVVLGDPSL ETSIKIIETL IKSGADALEI    50
GIPFSDPLAD GPTVQKSNLR ALSKNNTFFE YFKILKQLRK KNKKLPIGIL 100
IYANLVYNQG IDNFYFQCFN SGLDSVLIAD VPIEESKIFY NIANKYKINP 150
IFICPPDADA DFLYKISLYA QGFIYVLSRP GVTGIKNNTI ALPRDFINKI 200
KKYNSVPLLQ GFGISNPKQI KEAISSGLSG VICGSAIINI IEKYLNQEKK 250
MIKEIKKFTH LLKLSTKLE 269
Length:269
Mass (Da):30,323
Last modified:December 1, 2000 - v1
Checksum:iB1A59668F09BF3A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12987.1.
RefSeqiNP_240101.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12987; BAB12987; BAB12987.
GeneIDi1109716.
KEGGibuc:BU277.
PATRICi21244078. VBIBucAph127364_0287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12987.1 .
RefSeqi NP_240101.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57365.
SMRi P57365. Positions 2-267.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12987 ; BAB12987 ; BAB12987 .
GeneIDi 1109716.
KEGGi buc:BU277.
PATRICi 21244078. VBIBucAph127364_0287.

Phylogenomic databases

eggNOGi COG0159.
HOGENOMi HOG000223814.
KOi K01695.
OMAi ANPIEAM.
OrthoDBi EOG6RVG0K.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00044 .
BioCyci BAPH107806:GBZJ-277-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00131. Trp_synth_alpha.
InterProi IPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view ]
Pfami PF00290. Trp_syntA. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR00262. trpA. 1 hit.
PROSITEi PS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiTRPA_BUCAI
AccessioniPrimary (citable) accession number: P57365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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