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Protein

Protein GrpE 1

Gene

grpE1

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpE 1UniRule annotation
Alternative name(s):
HSP-70 cofactor 1UniRule annotation
Gene namesi
Name:grpE1UniRule annotation
Ordered Locus Names:BU252
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001137571 – 194Protein GrpE 1Add BLAST194

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi107806.BU252

Structurei

3D structure databases

ProteinModelPortaliP57340
SMRiP57340
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K90 Bacteria
COG0576 LUCA
HOGENOMiHOG000252084
KOiK03687
OMAiNDESHFI

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

P57340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHNEEEQLE KKIEKNQDPK INHKKYDSDN LIKKNLIQFL EIQLKESEEK
60 70 80 90 100
IIEKEEIVEK EIVLIHNRFN KEIEKSIKFS LEKIIIDFLP IIDNIERALN
110 120 130 140 150
LIETINLKQE KYTEILKKLQ FICNLLEKFF YLFNIKKIND TNVLFNPSIH
160 170 180 190
QAMSIHYTND IISNQIVTVM QSGYILHKSR LLRPAMVVVS KEKI
Length:194
Mass (Da):23,147
Last modified:December 1, 2000 - v1
Checksum:i5EF6C1194864DC6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA Translation: BAB12962.1
RefSeqiNP_240076.1, NC_002528.1
WP_010896026.1, NC_002528.1

Genome annotation databases

EnsemblBacteriaiBAB12962; BAB12962; BAB12962
GeneIDi1109691
KEGGibuc:BU252
PATRICifig|107806.10.peg.262

Similar proteinsi

Entry informationi

Entry nameiGRPE1_BUCAI
AccessioniPrimary (citable) accession number: P57340
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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