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P57338

- GMHA_BUCAI

UniProt

P57338 - GMHA_BUCAI

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Protein
Phosphoheptose isomerase
Gene
gmhA, lpcA, BU250
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Zinc By similarity
Metal bindingi65 – 651Zinc By similarity
Binding sitei65 – 651Substrate By similarity
Binding sitei124 – 1241Substrate By similarity
Metal bindingi172 – 1721Zinc By similarity
Binding sitei172 – 1721Substrate By similarity
Metal bindingi180 – 1801Zinc By similarity

GO - Molecular functioni

  1. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide core region biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-250-MONOMER.
UniPathwayiUPA00041; UER00436.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomerase (EC:5.3.1.28)
Alternative name(s):
Sedoheptulose 7-phosphate isomerase
Gene namesi
Name:gmhA
Synonyms:lpcA
Ordered Locus Names:BU250
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Phosphoheptose isomeraseUniRule annotation
PRO_0000136518Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP57338.
SMRiP57338. Positions 1-192.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 193157SIS
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 543Substrate binding By similarity
Regioni93 – 942Substrate binding By similarity
Regioni119 – 1213Substrate binding By similarity

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.
Contains 1 SIS domain.

Phylogenomic databases

eggNOGiCOG0279.
HOGENOMiHOG000237571.
KOiK03271.
OMAiHVFSRYV.
OrthoDBiEOG6384PC.

Family and domain databases

HAMAPiMF_00067. GmhA.
InterProiIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamiPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57338-1 [UniParc]FASTAAdd to Basket

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MYKKIIFSEF NSASKILKNF LEDKKQIENI QKAAILIAQS FKNEKKVISC    50
GNGGSHCDAV HFSEELTSVY RKKRSGYPAI SISDSSYISA VGNDFGYDQI 100
FSRFIQSVGH LGDILLAIST SGNSLNIVRA IEEAKKKKMK VIVLTGNNAG 150
KIKNLSDIEI CIPHCGYSDR IQEMHIKIIH ILILIIEKEM QKN 193
Length:193
Mass (Da):21,610
Last modified:December 1, 2000 - v1
Checksum:i7DB396B8DDF736E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12960.1.
RefSeqiNP_240074.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12960; BAB12960; BAB12960.
GeneIDi1109689.
KEGGibuc:BU250.
PATRICi21244024. VBIBucAph127364_0260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12960.1 .
RefSeqi NP_240074.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57338.
SMRi P57338. Positions 1-192.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12960 ; BAB12960 ; BAB12960 .
GeneIDi 1109689.
KEGGi buc:BU250.
PATRICi 21244024. VBIBucAph127364_0260.

Phylogenomic databases

eggNOGi COG0279.
HOGENOMi HOG000237571.
KOi K03271.
OMAi HVFSRYV.
OrthoDBi EOG6384PC.

Enzyme and pathway databases

UniPathwayi UPA00041 ; UER00436 .
BioCyci BAPH107806:GBZJ-250-MONOMER.

Family and domain databases

HAMAPi MF_00067. GmhA.
InterProi IPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view ]
Pfami PF13580. SIS_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00441. gmhA. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiGMHA_BUCAI
AccessioniPrimary (citable) accession number: P57338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity.
B.aphidicola is not able to make lipopolysaccharides (LPS), and except lpcA and kdtB, the genes responsible for the biosynthesis of the LPS components are missing from the genome.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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