ID   FLHA_BUCAI              Reviewed;         696 AA.
AC   P57335;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=Flagellar biosynthesis protein FlhA;
GN   Name=flhA; OrderedLocusNames=BU241;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC       apparatus. Together with FliI and FliH, may constitute the export
CC       apparatus of flagellin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB12956.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000003; BAB12956.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_240070.2; NC_002528.1.
DR   RefSeq; WP_010896024.1; NC_002528.1.
DR   AlphaFoldDB; P57335; -.
DR   SMR; P57335; -.
DR   STRING; 563178.BUAP5A_237; -.
DR   EnsemblBacteria; BAB12956; BAB12956; BAB12956.
DR   KEGG; buc:BU241; -.
DR   PATRIC; fig|107806.10.peg.254; -.
DR   eggNOG; COG1298; Bacteria.
DR   HOGENOM; CLU_015346_3_0_6; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR   Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR   Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR025505; FHIPEP_CS.
DR   InterPro; IPR006301; FlhA.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   NCBIfam; TIGR01398; FlhA; 1.
DR   PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR   PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   PROSITE; PS00994; FHIPEP; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..696
FT                   /note="Flagellar biosynthesis protein FlhA"
FT                   /id="PRO_0000190012"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   696 AA;  78304 MW;  756F9A0919FA2B9D CRC64;
     MINFSSLLRI VKSLKTTQWQ ILAGPILILM ILSMMVLPLA PFVLDVFFTF NIALSIIILL
     VSMFTRHTLE FTAFPTILLF STLLRLALNV ASTRVIFLRG HTGTNSAGRV IESFGHFLVG
     GNFAIGIVVF IILVIINFIV ITKGASRIAE VGARFILDAM PGKQMAIDAD LNAGLIGEEK
     AKKRRIKITQ EADFYGSMDG ASKFVRGDAI AGILIMVINI FGGLIIGLIQ HHMFLNKAVE
     VYTLLTIGDG LVAQIPALVI STAAGVIVTR VSSNQNVGEQ MASQLFYNPQ VILLSAIVLG
     VLGLVPGMPN IIFLVFTVLL FILSWWLYEK KYDLENDFIK SNKKYKFIHD AISEASWNDV
     ELEDPIRIEI GYKLTPMTDI NKKGDLLDRI RIVRKKVAQE IGFLPPLVRI KNNMHLSGNS
     YRIFIKGVEV GQGKCFYGRF MAIHSGRETE SLPFEKVYEP TFGLSGYWID EEFKNKAQKK
     GYSVIESSVV LSTHLNFLIT NHIDDLFGRQ EAQQLLERVT IDHPKLTEDL IPNTINLTIF
     HKILRNLLLE HVPIRDMRTI LETLSEHADT QKDPNELTSI VRIALRKIII QKLFNQNNII
     EIIGLEPNLE RLLLNSLKSG TDTIEPNLSE NLLIQTKEAI KKQLLIGSPL VLLVRHSLRY
     FLSKFLRQNF PELTVLSQFE IIDVKEIKMT NIIGTS
//